General Information
| Gene ID | 5599 |
|---|---|
| Gene Symbol | MAPK8 |
| Gene Name | mitogen-activated protein kinase 8 |
| Gene Type | protein-coding |
| Cytoband | 10q11.22 |
| Ensembl ID | ENSG00000107643 |
| #miR regulators | --- |
| Omim ID | 601158 |
| Gene ontology |
GO:0001503: ossification GO:0002224: toll-like receptor signaling pathway GO:0002755: MyD88-dependent toll-like receptor signaling pathway GO:0002756: MyD88-independent toll-like receptor signaling pathway GO:0006915: apoptotic process GO:0006950: response to stress GO:0007254: JNK cascade GO:0007258: JUN phosphorylation GO:0043066: negative regulation of apoptotic process GO:0009411: response to UV GO:0010628: positive regulation of gene expression GO:0018105: peptidyl-serine phosphorylation GO:0018107: peptidyl-threonine phosphorylation GO:0046686: response to cadmium ion GO:0071260: cellular response to mechanical stimulus GO:0031063: regulation of histone deacetylation GO:0032091: negative regulation of protein binding GO:0032880: regulation of protein localization GO:0034134: toll-like receptor 2 signaling pathway GO:0034138: toll-like receptor 3 signaling pathway GO:0034142: toll-like receptor 4 signaling pathway GO:0034146: toll-like receptor 5 signaling pathway GO:0034162: toll-like receptor 9 signaling pathway GO:0034166: toll-like receptor 10 signaling pathway GO:0035666: TRIF-dependent toll-like receptor signaling pathway GO:0038095: Fc-epsilon receptor signaling pathway GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway GO:0043065: positive regulation of apoptotic process GO:0045087: innate immune response GO:0048011: neurotrophin TRK receptor signaling pathway GO:0051090: regulation of sequence-specific DNA binding transcription factor activity GO:0051403: stress-activated MAPK cascade GO:0090045: positive regulation of deacetylase activity GO:0097190: apoptotic signaling pathway GO:0097193: intrinsic apoptotic signaling pathway GO:1900740: positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:2000017: positive regulation of determination of dorsal identity GO:2001235: positive regulation of apoptotic signaling pathway GO:0005739: mitochondrion GO:0005829: cytosol GO:0005634: nucleus GO:0005654: nucleoplasm GO:0005515: protein binding GO:0004674: protein serine/threonine kinase activity GO:0004705: JUN kinase activity GO:0005524: ATP binding GO:0035033: histone deacetylase regulator activity GO:0042826: histone deacetylase binding |
| KEGG pathways |
4010: MAPK signaling pathway 4012: ErbB signaling pathway 4141: Protein processing in endoplasmic reticulum 4310: Wnt signaling pathway 4380: Osteoclast differentiation 4510: Focal adhesion 4620: Toll-like receptor signaling pathway 4621: NOD-like receptor signaling pathway 4622: RIG-I-like receptor signaling pathway 4664: Fc epsilon RI signaling pathway 4722: Neurotrophin signaling pathway 4910: Insulin signaling pathway 4912: GnRH signaling pathway 4914: Progesterone-mediated oocyte maturation 4920: Adipocytokine signaling pathway 4930: Type II diabetes mellitus 5120: Epithelial cell signaling in Helicobacter pylori infection 5131: Shigellosis 5142: Chagas disease (American trypanosomiasis) 5145: Toxoplasmosis 5160: Hepatitis C 5200: Pathways in cancer 5210: Colorectal cancer 5212: Pancreatic cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 11418138 | pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. | no | no |
| 11451946 | Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation. | no | no |
| 12689679 | Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. | yes | yes |
| 15936998 | Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. | no | no |
| 16167336 | Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. | no | no |
| 17116726 | Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. | no | no |
| 17218775 | Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. | no | no |
| 17412493 | 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. | no | no |
| 18524773 | FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. | no | no |
| 18606492 | The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. | no | no |
| 18757369 | Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. | no | no |
| 18814141 | Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. | no | no |
| 18986328 | Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. | no | no |
| 21667022 | The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. | no | no |
| 22068640 | Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. | no | no |
| 22128168 | Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. | no | no |
| 22227330 | Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. | no | no |
| 22387266 | Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. | no | no |
| 22583777 | Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro. | yes | no |
| 22688575 | Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. | no | no |
| 22797704 | NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation. | no | no |
| 22849560 | Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. | no | no |
| 23045411 | Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin. | yes | no |
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