Results for MAPK8

General Information

Gene ID 5599
Gene Symbol MAPK8
Gene Name mitogen-activated protein kinase 8
Gene Type protein-coding
Cytoband 10q11.22
Ensembl ID ENSG00000107643
#miR regulators ---
Omim ID 601158
Gene ontology GO:0001503: ossification
GO:0002224: toll-like receptor signaling pathway
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0006915: apoptotic process
GO:0006950: response to stress
GO:0007254: JNK cascade
GO:0007258: JUN phosphorylation
GO:0043066: negative regulation of apoptotic process
GO:0009411: response to UV
GO:0010628: positive regulation of gene expression
GO:0018105: peptidyl-serine phosphorylation
GO:0018107: peptidyl-threonine phosphorylation
GO:0046686: response to cadmium ion
GO:0071260: cellular response to mechanical stimulus
GO:0031063: regulation of histone deacetylation
GO:0032091: negative regulation of protein binding
GO:0032880: regulation of protein localization
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0043065: positive regulation of apoptotic process
GO:0045087: innate immune response
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0051090: regulation of sequence-specific DNA binding transcription factor activity
GO:0051403: stress-activated MAPK cascade
GO:0090045: positive regulation of deacetylase activity
GO:0097190: apoptotic signaling pathway
GO:0097193: intrinsic apoptotic signaling pathway
GO:1900740: positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000017: positive regulation of determination of dorsal identity
GO:2001235: positive regulation of apoptotic signaling pathway
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005515: protein binding
GO:0004674: protein serine/threonine kinase activity
GO:0004705: JUN kinase activity
GO:0005524: ATP binding
GO:0035033: histone deacetylase regulator activity
GO:0042826: histone deacetylase binding
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4141: Protein processing in endoplasmic reticulum
4310: Wnt signaling pathway
4380: Osteoclast differentiation
4510: Focal adhesion
4620: Toll-like receptor signaling pathway
4621: NOD-like receptor signaling pathway
4622: RIG-I-like receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4722: Neurotrophin signaling pathway
4910: Insulin signaling pathway
4912: GnRH signaling pathway
4914: Progesterone-mediated oocyte maturation
4920: Adipocytokine signaling pathway
4930: Type II diabetes mellitus
5120: Epithelial cell signaling in Helicobacter pylori infection
5131: Shigellosis
5142: Chagas disease (American trypanosomiasis)
5145: Toxoplasmosis
5160: Hepatitis C
5200: Pathways in cancer
5210: Colorectal cancer
5212: Pancreatic cancer

PubMed abstracts associated with MAPK8

PMID Title Tumor Value
11418138 pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. no no
11451946 Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation. no no
12689679 Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. yes yes
15936998 Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. no no
16167336 Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. no no
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no
17218775 Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. no no
17412493 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. no no
18524773 FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. no no
18606492 The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. no no
18757369 Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. no no
18814141 Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. no no
18986328 Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. no no
21667022 The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. no no
22068640 Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. no no
22128168 Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. no no
22227330 Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. no no
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no
22583777 Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro. yes no
22688575 Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. no no
22797704 NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation. no no
23045411 Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin. yes no
22849560 Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. no no
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