General Information
Gene ID | 5604 |
---|---|
Gene Symbol | MAP2K1 |
Gene Name | mitogen-activated protein kinase kinase 1 |
Gene Type | protein-coding |
Cytoband | 15q22.1-q22.33 |
Ensembl ID | ENSG00000169032 |
#miR regulators | 14 |
Omim ID | 176872 615279 |
Gene ontology |
GO:0000165: MAPK cascade GO:0000186: activation of MAPKK activity GO:0000187: activation of MAPK activity GO:0002224: toll-like receptor signaling pathway GO:0002755: MyD88-dependent toll-like receptor signaling pathway GO:0002756: MyD88-independent toll-like receptor signaling pathway GO:0003056: regulation of vascular smooth muscle contraction GO:0007165: signal transduction GO:0006928: cellular component movement GO:0006935: chemotaxis GO:0006979: response to oxidative stress GO:0007050: cell cycle arrest GO:0007067: mitosis GO:0007173: epidermal growth factor receptor signaling pathway GO:0007264: small GTPase mediated signal transduction GO:0007265: Ras protein signal transduction GO:0007411: axon guidance GO:0008283: cell proliferation GO:0008285: negative regulation of cell proliferation GO:0008286: insulin receptor signaling pathway GO:0008543: fibroblast growth factor receptor signaling pathway GO:0030216: keratinocyte differentiation GO:0030335: positive regulation of cell migration GO:0032320: positive regulation of Ras GTPase activity GO:0032402: melanosome transport GO:0032872: regulation of stress-activated MAPK cascade GO:0032968: positive regulation of transcription elongation from RNA polymerase II promoter GO:0034111: negative regulation of homotypic cell-cell adhesion GO:0034134: toll-like receptor 2 signaling pathway GO:0034138: toll-like receptor 3 signaling pathway GO:0034142: toll-like receptor 4 signaling pathway GO:0034146: toll-like receptor 5 signaling pathway GO:0034162: toll-like receptor 9 signaling pathway GO:0034166: toll-like receptor 10 signaling pathway GO:0035666: TRIF-dependent toll-like receptor signaling pathway GO:0038095: Fc-epsilon receptor signaling pathway GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway GO:0045087: innate immune response GO:0045597: positive regulation of cell differentiation GO:0046579: positive regulation of Ras protein signal transduction GO:0047496: vesicle transport along microtubule GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048313: Golgi inheritance GO:0048678: response to axon injury GO:0048870: cell motility GO:0051291: protein heterooligomerization GO:0051384: response to glucocorticoid stimulus GO:0051403: stress-activated MAPK cascade GO:0060674: placenta blood vessel development GO:0060711: labyrinthine layer development GO:0071902: positive regulation of protein serine/threonine kinase activity GO:0090170: regulation of Golgi inheritance GO:0090398: cellular senescence GO:2000641: regulation of early endosome to late endosome transport GO:0005886: plasma membrane GO:0005739: mitochondrion GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005769: early endosome GO:0005770: late endosome GO:0005794: Golgi apparatus GO:0005816: spindle pole body GO:0005925: focal adhesion GO:0005938: cell cortex GO:0032839: dendrite cytoplasm GO:0043204: perikaryon GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0004672: protein kinase activity GO:0004674: protein serine/threonine kinase activity GO:0004708: MAP kinase kinase activity GO:0004712: protein serine/threonine/tyrosine kinase activity GO:0004713: protein tyrosine kinase activity GO:0004728: receptor signaling protein tyrosine phosphatase activity GO:0005524: ATP binding GO:0017016: Ras GTPase binding GO:0031435: mitogen-activated protein kinase kinase kinase binding GO:0043539: protein serine/threonine kinase activator activity |
KEGG pathways |
4010: MAPK signaling pathway 4012: ErbB signaling pathway 4062: Chemokine signaling pathway 4114: Oocyte meiosis 4270: Vascular smooth muscle contraction 4320: Dorso-ventral axis formation 4370: VEGF signaling pathway 4380: Osteoclast differentiation 4510: Focal adhesion 4540: Gap junction 4620: Toll-like receptor signaling pathway 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4664: Fc epsilon RI signaling pathway 4666: Fc gamma R-mediated phagocytosis 4720: Long-term potentiation 4722: Neurotrophin signaling pathway 4730: Long-term depression 4810: Regulation of actin cytoskeleton 4910: Insulin signaling pathway 4912: GnRH signaling pathway 4914: Progesterone-mediated oocyte maturation 4916: Melanogenesis 5020: Prion diseases 5200: Pathways in cancer 5210: Colorectal cancer 5211: Renal cell carcinoma 5212: Pancreatic cancer 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5216: Thyroid cancer 5218: Melanoma 5219: Bladder cancer 5220: Chronic myeloid leukemia 5221: Acute myeloid leukemia 5223: Non-small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
12388161 | 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. | no | no |
17412493 | 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. | no | no |
19496172 | Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. | no | no |
21378337 | The role of MAPK pathway in bone and soft tissue tumors. | yes | no |
22935974 | Mitogen-activated protein kinase pathway in osteosarcoma. | yes | yes |
23262982 | Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. | no | no |
23507142 | miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. | yes | no |
title | all | all |