Results for MAP2K1

General Information

Gene ID 5604
Gene Symbol MAP2K1
Gene Name mitogen-activated protein kinase kinase 1
Gene Type protein-coding
Cytoband 15q22.1-q22.33
Ensembl ID ENSG00000169032
#miR regulators 14
Omim ID 176872 615279
Gene ontology GO:0000165: MAPK cascade
GO:0000186: activation of MAPKK activity
GO:0000187: activation of MAPK activity
GO:0002224: toll-like receptor signaling pathway
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0003056: regulation of vascular smooth muscle contraction
GO:0007165: signal transduction
GO:0006928: cellular component movement
GO:0006935: chemotaxis
GO:0006979: response to oxidative stress
GO:0007050: cell cycle arrest
GO:0007067: mitosis
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007264: small GTPase mediated signal transduction
GO:0007265: Ras protein signal transduction
GO:0007411: axon guidance
GO:0008283: cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0030216: keratinocyte differentiation
GO:0030335: positive regulation of cell migration
GO:0032320: positive regulation of Ras GTPase activity
GO:0032402: melanosome transport
GO:0032872: regulation of stress-activated MAPK cascade
GO:0032968: positive regulation of transcription elongation from RNA polymerase II promoter
GO:0034111: negative regulation of homotypic cell-cell adhesion
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087: innate immune response
GO:0045597: positive regulation of cell differentiation
GO:0046579: positive regulation of Ras protein signal transduction
GO:0047496: vesicle transport along microtubule
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048313: Golgi inheritance
GO:0048678: response to axon injury
GO:0048870: cell motility
GO:0051291: protein heterooligomerization
GO:0051384: response to glucocorticoid stimulus
GO:0051403: stress-activated MAPK cascade
GO:0060674: placenta blood vessel development
GO:0060711: labyrinthine layer development
GO:0071902: positive regulation of protein serine/threonine kinase activity
GO:0090170: regulation of Golgi inheritance
GO:0090398: cellular senescence
GO:2000641: regulation of early endosome to late endosome transport
GO:0005886: plasma membrane
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005769: early endosome
GO:0005770: late endosome
GO:0005794: Golgi apparatus
GO:0005816: spindle pole body
GO:0005925: focal adhesion
GO:0005938: cell cortex
GO:0032839: dendrite cytoplasm
GO:0043204: perikaryon
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0004672: protein kinase activity
GO:0004674: protein serine/threonine kinase activity
GO:0004708: MAP kinase kinase activity
GO:0004712: protein serine/threonine/tyrosine kinase activity
GO:0004713: protein tyrosine kinase activity
GO:0004728: receptor signaling protein tyrosine phosphatase activity
GO:0005524: ATP binding
GO:0017016: Ras GTPase binding
GO:0031435: mitogen-activated protein kinase kinase kinase binding
GO:0043539: protein serine/threonine kinase activator activity
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4062: Chemokine signaling pathway
4114: Oocyte meiosis
4270: Vascular smooth muscle contraction
4320: Dorso-ventral axis formation
4370: VEGF signaling pathway
4380: Osteoclast differentiation
4510: Focal adhesion
4540: Gap junction
4620: Toll-like receptor signaling pathway
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4666: Fc gamma R-mediated phagocytosis
4720: Long-term potentiation
4722: Neurotrophin signaling pathway
4730: Long-term depression
4810: Regulation of actin cytoskeleton
4910: Insulin signaling pathway
4912: GnRH signaling pathway
4914: Progesterone-mediated oocyte maturation
4916: Melanogenesis
5020: Prion diseases
5200: Pathways in cancer
5210: Colorectal cancer
5211: Renal cell carcinoma
5212: Pancreatic cancer
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5216: Thyroid cancer
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5223: Non-small cell lung cancer

PubMed abstracts associated with MAP2K1

PMID Title Tumor Value
12388161 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. no no
17412493 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. no no
19496172 Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. no no
21378337 The role of MAPK pathway in bone and soft tissue tumors. yes no
22935974 Mitogen-activated protein kinase pathway in osteosarcoma. yes yes
23262982 Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. no no
23507142 miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. yes no
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