General Information
| Gene ID | 5605 |
|---|---|
| Gene Symbol | MAP2K2 |
| Gene Name | mitogen-activated protein kinase kinase 2 |
| Gene Type | protein-coding |
| Cytoband | 19p13.3 |
| Ensembl ID | ENSG00000126934 |
| #miR regulators | --- |
| Omim ID | 601263 615280 |
| Gene ontology |
GO:0000165: MAPK cascade GO:0000186: activation of MAPKK activity GO:0000187: activation of MAPK activity GO:0002224: toll-like receptor signaling pathway GO:0002755: MyD88-dependent toll-like receptor signaling pathway GO:0002756: MyD88-independent toll-like receptor signaling pathway GO:0006468: protein phosphorylation GO:0007173: epidermal growth factor receptor signaling pathway GO:0007264: small GTPase mediated signal transduction GO:0007265: Ras protein signal transduction GO:0007411: axon guidance GO:0008286: insulin receptor signaling pathway GO:0008543: fibroblast growth factor receptor signaling pathway GO:0032872: regulation of stress-activated MAPK cascade GO:0034134: toll-like receptor 2 signaling pathway GO:0034138: toll-like receptor 3 signaling pathway GO:0034142: toll-like receptor 4 signaling pathway GO:0034146: toll-like receptor 5 signaling pathway GO:0034162: toll-like receptor 9 signaling pathway GO:0034166: toll-like receptor 10 signaling pathway GO:0035666: TRIF-dependent toll-like receptor signaling pathway GO:0036289: peptidyl-serine autophosphorylation GO:0038095: Fc-epsilon receptor signaling pathway GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway GO:0045087: innate immune response GO:0048011: neurotrophin TRK receptor signaling pathway GO:0051403: stress-activated MAPK cascade GO:0070371: ERK1 and ERK2 cascade GO:0071902: positive regulation of protein serine/threonine kinase activity GO:0090170: regulation of Golgi inheritance GO:2000147: positive regulation of cell motility GO:2000641: regulation of early endosome to late endosome transport GO:0005739: mitochondrion GO:0005576: extracellular region GO:0005829: cytosol GO:0005783: endoplasmic reticulum GO:0005778: peroxisomal membrane GO:0005634: nucleus GO:0005769: early endosome GO:0005770: late endosome GO:0005794: Golgi apparatus GO:0005874: microtubule GO:0005911: cell-cell junction GO:0005925: focal adhesion GO:0005938: cell cortex GO:0009898: internal side of plasma membrane GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0004674: protein serine/threonine kinase activity GO:0004708: MAP kinase kinase activity GO:0004712: protein serine/threonine/tyrosine kinase activity GO:0004713: protein tyrosine kinase activity GO:0005524: ATP binding GO:0030165: PDZ domain binding GO:0032947: protein complex scaffold GO:0043539: protein serine/threonine kinase activator activity GO:0097110: scaffold protein binding |
| KEGG pathways |
4010: MAPK signaling pathway 4012: ErbB signaling pathway 4270: Vascular smooth muscle contraction 4370: VEGF signaling pathway 4540: Gap junction 4620: Toll-like receptor signaling pathway 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4664: Fc epsilon RI signaling pathway 4720: Long-term potentiation 4722: Neurotrophin signaling pathway 4730: Long-term depression 4810: Regulation of actin cytoskeleton 4910: Insulin signaling pathway 4912: GnRH signaling pathway 4916: Melanogenesis 5020: Prion diseases 5200: Pathways in cancer 5211: Renal cell carcinoma 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5216: Thyroid cancer 5218: Melanoma 5219: Bladder cancer 5220: Chronic myeloid leukemia 5221: Acute myeloid leukemia 5223: Non-small cell lung cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 17412493 | 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. | no | no |
| 21378337 | The role of MAPK pathway in bone and soft tissue tumors. | yes | no |
| 22935974 | Mitogen-activated protein kinase pathway in osteosarcoma. | yes | yes |
| 23507142 | miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. | yes | no |
| title | all | all |