Results for MAP2K2

General Information

Gene ID 5605
Gene Symbol MAP2K2
Gene Name mitogen-activated protein kinase kinase 2
Gene Type protein-coding
Cytoband 19p13.3
Ensembl ID ENSG00000126934
#miR regulators ---
Omim ID 601263 615280
Gene ontology GO:0000165: MAPK cascade
GO:0000186: activation of MAPKK activity
GO:0000187: activation of MAPK activity
GO:0002224: toll-like receptor signaling pathway
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0006468: protein phosphorylation
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007264: small GTPase mediated signal transduction
GO:0007265: Ras protein signal transduction
GO:0007411: axon guidance
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0032872: regulation of stress-activated MAPK cascade
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0036289: peptidyl-serine autophosphorylation
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087: innate immune response
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0051403: stress-activated MAPK cascade
GO:0070371: ERK1 and ERK2 cascade
GO:0071902: positive regulation of protein serine/threonine kinase activity
GO:0090170: regulation of Golgi inheritance
GO:2000147: positive regulation of cell motility
GO:2000641: regulation of early endosome to late endosome transport
GO:0005739: mitochondrion
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0005783: endoplasmic reticulum
GO:0005778: peroxisomal membrane
GO:0005634: nucleus
GO:0005769: early endosome
GO:0005770: late endosome
GO:0005794: Golgi apparatus
GO:0005874: microtubule
GO:0005911: cell-cell junction
GO:0005925: focal adhesion
GO:0005938: cell cortex
GO:0009898: internal side of plasma membrane
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0004674: protein serine/threonine kinase activity
GO:0004708: MAP kinase kinase activity
GO:0004712: protein serine/threonine/tyrosine kinase activity
GO:0004713: protein tyrosine kinase activity
GO:0005524: ATP binding
GO:0030165: PDZ domain binding
GO:0032947: protein complex scaffold
GO:0043539: protein serine/threonine kinase activator activity
GO:0097110: scaffold protein binding
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4270: Vascular smooth muscle contraction
4370: VEGF signaling pathway
4540: Gap junction
4620: Toll-like receptor signaling pathway
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4720: Long-term potentiation
4722: Neurotrophin signaling pathway
4730: Long-term depression
4810: Regulation of actin cytoskeleton
4910: Insulin signaling pathway
4912: GnRH signaling pathway
4916: Melanogenesis
5020: Prion diseases
5200: Pathways in cancer
5211: Renal cell carcinoma
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5216: Thyroid cancer
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5223: Non-small cell lung cancer

PubMed abstracts associated with MAP2K2

PMID Title Tumor Value
17412493 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. no no
21378337 The role of MAPK pathway in bone and soft tissue tumors. yes no
22935974 Mitogen-activated protein kinase pathway in osteosarcoma. yes yes
23507142 miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. yes no
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