Results for EIF2AK2

General Information

Gene ID 5610
Gene Symbol EIF2AK2
Gene Name eukaryotic translation initiation factor 2-alpha kinase 2
Gene Type protein-coding
Cytoband 2p22-p21
Ensembl ID ENSG00000055332
#miR regulators 3
Omim ID 176871
Gene ontology GO:0000186: activation of MAPKK activity
GO:0001819: positive regulation of cytokine production
GO:0009615: response to virus
GO:0006351: transcription, DNA-dependent
GO:0006412: translation
GO:0006468: protein phosphorylation
GO:0006926: virus-infected cell apoptotic process
GO:0008285: negative regulation of cell proliferation
GO:0017148: negative regulation of translation
GO:0019048: modulation by virus of host morphology or physiology
GO:0019054: modulation by virus of host process
GO:0019058: viral infectious cycle
GO:0030683: evasion or tolerance by virus of host immune response
GO:0030968: endoplasmic reticulum unfolded protein response
GO:0032722: positive regulation of chemokine production
GO:0032874: positive regulation of stress-activated MAPK cascade
GO:0033689: negative regulation of osteoblast proliferation
GO:0035455: response to interferon-alpha
GO:0045071: negative regulation of viral genome replication
GO:0045087: innate immune response
GO:0046777: protein autophosphorylation
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051607: defense response to virus
GO:1900225: regulation of NLRP3 inflammasome complex assembly
GO:1901224: positive regulation of NIK/NF-kappaB cascade
GO:1901532: regulation of hematopoietic progenitor cell differentiation
GO:1902033: regulation of hematopoietic stem cell proliferation
GO:1902036: regulation of hematopoietic stem cell differentiation
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0003725: double-stranded RNA binding
GO:0004672: protein kinase activity
GO:0004674: protein serine/threonine kinase activity
GO:0004694: eukaryotic translation initiation factor 2alpha kinase activity
GO:0004715: non-membrane spanning protein tyrosine kinase activity
GO:0005524: ATP binding
GO:0008601: protein phosphatase type 2A regulator activity
KEGG pathways 4141: Protein processing in endoplasmic reticulum
5160: Hepatitis C

PubMed abstracts associated with EIF2AK2

PMID Title Tumor Value
15625311 Okadaic acid induces apoptosis through double-stranded RNA-dependent protein kinase/eukaryotic initiation factor-2alpha pathway in human osteoblastic MG63 cells. no no
17014383 Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells. no no
18384113 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest. no no
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