General Information
Gene ID | 5610 |
---|---|
Gene Symbol | EIF2AK2 |
Gene Name | eukaryotic translation initiation factor 2-alpha kinase 2 |
Gene Type | protein-coding |
Cytoband | 2p22-p21 |
Ensembl ID | ENSG00000055332 |
#miR regulators | 3 |
Omim ID | 176871 |
Gene ontology |
GO:0000186: activation of MAPKK activity GO:0001819: positive regulation of cytokine production GO:0009615: response to virus GO:0006351: transcription, DNA-dependent GO:0006412: translation GO:0006468: protein phosphorylation GO:0006926: virus-infected cell apoptotic process GO:0008285: negative regulation of cell proliferation GO:0017148: negative regulation of translation GO:0019048: modulation by virus of host morphology or physiology GO:0019054: modulation by virus of host process GO:0019058: viral infectious cycle GO:0030683: evasion or tolerance by virus of host immune response GO:0030968: endoplasmic reticulum unfolded protein response GO:0032722: positive regulation of chemokine production GO:0032874: positive regulation of stress-activated MAPK cascade GO:0033689: negative regulation of osteoblast proliferation GO:0035455: response to interferon-alpha GO:0045071: negative regulation of viral genome replication GO:0045087: innate immune response GO:0046777: protein autophosphorylation GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0051607: defense response to virus GO:1900225: regulation of NLRP3 inflammasome complex assembly GO:1901224: positive regulation of NIK/NF-kappaB cascade GO:1901532: regulation of hematopoietic progenitor cell differentiation GO:1902033: regulation of hematopoietic stem cell proliferation GO:1902036: regulation of hematopoietic stem cell differentiation GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0003725: double-stranded RNA binding GO:0004672: protein kinase activity GO:0004674: protein serine/threonine kinase activity GO:0004694: eukaryotic translation initiation factor 2alpha kinase activity GO:0004715: non-membrane spanning protein tyrosine kinase activity GO:0005524: ATP binding GO:0008601: protein phosphatase type 2A regulator activity |
KEGG pathways |
4141: Protein processing in endoplasmic reticulum 5160: Hepatitis C |
PMID | Title | Tumor | Value |
---|---|---|---|
15625311 | Okadaic acid induces apoptosis through double-stranded RNA-dependent protein kinase/eukaryotic initiation factor-2alpha pathway in human osteoblastic MG63 cells. | no | no |
17014383 | Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells. | no | no |
18384113 | 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest. | no | no |
title | all | all |