Results for PTCH1

General Information

Gene ID 5727
Gene Symbol PTCH1
Gene Name patched 1
Gene Type protein-coding
Cytoband 9q22.3
Ensembl ID ENSG00000185920
#miR regulators 12
Omim ID 109400 601309 610828
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001658: branching involved in ureteric bud morphogenesis
GO:0001843: neural tube closure
GO:0003007: heart morphogenesis
GO:0016485: protein processing
GO:0007224: smoothened signaling pathway
GO:0007346: regulation of mitotic cell cycle
GO:0009887: organ morphogenesis
GO:0007420: brain development
GO:0008544: epidermis development
GO:0008589: regulation of smoothened signaling pathway
GO:0009953: dorsal/ventral pattern formation
GO:0010157: response to chlorate
GO:0010875: positive regulation of cholesterol efflux
GO:0021522: spinal cord motor neuron differentiation
GO:0021532: neural tube patterning
GO:0021997: neural plate axis specification
GO:0030326: embryonic limb morphogenesis
GO:0032880: regulation of protein localization
GO:0035108: limb morphogenesis
GO:0035137: hindlimb morphogenesis
GO:0040015: negative regulation of multicellular organism growth
GO:0042593: glucose homeostasis
GO:0043433: negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043616: keratinocyte proliferation
GO:0045668: negative regulation of osteoblast differentiation
GO:0045879: negative regulation of smoothened signaling pathway
GO:0050680: negative regulation of epithelial cell proliferation
GO:0051782: negative regulation of cell division
GO:0060037: pharyngeal system development
GO:0060603: mammary gland duct morphogenesis
GO:0060644: mammary gland epithelial cell differentiation
GO:0060831: smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061005: cell differentiation involved in kidney development
GO:0061053: somite development
GO:0071397: cellular response to cholesterol
GO:0072001: renal system development
GO:0072203: cell proliferation involved in metanephros development
GO:0072661: protein targeting to plasma membrane
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0043231: intracellular membrane-bounded organelle
GO:0005794: Golgi apparatus
GO:0005901: caveola
GO:0030496: midbody
GO:0048471: perinuclear region of cytoplasm
GO:0072372: primary cilium
GO:0005515: protein binding
GO:0005113: patched binding
GO:0005119: smoothened binding
GO:0008158: hedgehog receptor activity
GO:0008201: heparin binding
GO:0015485: cholesterol binding
GO:0030332: cyclin binding
GO:0032403: protein complex binding
GO:0097108: hedgehog family protein binding
KEGG pathways 4340: Hedgehog signaling pathway
5200: Pathways in cancer
5217: Basal cell carcinoma

PubMed abstracts associated with PTCH1

PMID Title Tumor Value
20067614 Smoothened as a new therapeutic target for human osteosarcoma. yes no
title all all