Results for PTEN

General Information

Gene ID 5728
Gene Symbol PTEN
Gene Name phosphatase and tensin homolog
Gene Type protein-coding
Cytoband 10q23.3
Ensembl ID ENSG00000171862
#miR regulators 17
Omim ID 153480 155600 158350 176807 188470 275355 276950 601728 605309 607174 608089 613028
Gene ontology GO:0000079: regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001525: angiogenesis
GO:0001933: negative regulation of protein phosphorylation
GO:0002902: regulation of B cell apoptotic process
GO:0006915: apoptotic process
GO:0006470: protein dephosphorylation
GO:0006644: phospholipid metabolic process
GO:0006661: phosphatidylinositol biosynthetic process
GO:0007092: activation of mitotic anaphase-promoting complex activity
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007270: neuron-neuron synaptic transmission
GO:0007416: synapse assembly
GO:0007417: central nervous system development
GO:0007507: heart development
GO:0007611: learning or memory
GO:0007626: locomotory behavior
GO:0043066: negative regulation of apoptotic process
GO:0008283: cell proliferation
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010975: regulation of neuron projection development
GO:0014067: negative regulation of phosphatidylinositol 3-kinase cascade
GO:0016477: cell migration
GO:0050821: protein stabilization
GO:0048015: phosphatidylinositol-mediated signaling
GO:0021542: dentate gyrus development
GO:0021955: central nervous system neuron axonogenesis
GO:0050852: T cell receptor signaling pathway
GO:0030336: negative regulation of cell migration
GO:0031642: negative regulation of myelination
GO:0031647: regulation of protein stability
GO:0031658: negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032286: central nervous system myelin maintenance
GO:0032535: regulation of cellular component size
GO:0033032: regulation of myeloid cell apoptotic process
GO:0033555: multicellular organismal response to stress
GO:0035176: social behavior
GO:0035335: peptidyl-tyrosine dephosphorylation
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042711: maternal behavior
GO:0043491: protein kinase B signaling cascade
GO:0043542: endothelial cell migration
GO:0043647: inositol phosphate metabolic process
GO:0044281: small molecule metabolic process
GO:0045087: innate immune response
GO:0045475: locomotor rhythm
GO:0045792: negative regulation of cell size
GO:0046621: negative regulation of organ growth
GO:0046855: inositol phosphate dephosphorylation
GO:0046856: phosphatidylinositol dephosphorylation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048738: cardiac muscle tissue development
GO:0048853: forebrain morphogenesis
GO:0048854: brain morphogenesis
GO:0050680: negative regulation of epithelial cell proliferation
GO:0050771: negative regulation of axonogenesis
GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051895: negative regulation of focal adhesion assembly
GO:0051898: negative regulation of protein kinase B signaling cascade
GO:0060024: rhythmic synaptic transmission
GO:0060070: canonical Wnt receptor signaling pathway
GO:0060074: synapse maturation
GO:0060134: prepulse inhibition
GO:0060179: male mating behavior
GO:0060291: long-term synaptic potentiation
GO:0060736: prostate gland growth
GO:0060997: dendritic spine morphogenesis
GO:0061002: negative regulation of dendritic spine morphogenesis
GO:0090071: negative regulation of ribosome biogenesis
GO:0090344: negative regulation of cell aging
GO:0090394: negative regulation of excitatory postsynaptic membrane potential
GO:0097105: presynaptic membrane assembly
GO:0097107: postsynaptic density assembly
GO:2000060: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000134: negative regulation of G1/S transition of mitotic cell cycle
GO:2000463: positive regulation of excitatory postsynaptic membrane potential
GO:2000808: negative regulation of synaptic vesicle clustering
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0009898: internal side of plasma membrane
GO:0016605: PML body
GO:0043005: neuron projection
GO:0035749: myelin sheath adaxonal region
GO:0042995: cell projection
GO:0043220: Schmidt-Lanterman incisure
GO:0005515: protein binding
GO:0000287: magnesium ion binding
GO:0004438: phosphatidylinositol-3-phosphatase activity
GO:0004721: phosphoprotein phosphatase activity
GO:0004722: protein serine/threonine phosphatase activity
GO:0004725: protein tyrosine phosphatase activity
GO:0008289: lipid binding
GO:0008138: protein tyrosine/serine/threonine phosphatase activity
GO:0010997: anaphase-promoting complex binding
GO:0016314: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0019899: enzyme binding
GO:0019901: protein kinase binding
GO:0030165: PDZ domain binding
GO:0051717: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051800: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
KEGG pathways 562: Inositol phosphate metabolism
4070: Phosphatidylinositol signaling system
4115: p53 signaling pathway
4510: Focal adhesion
4530: Tight junction
5200: Pathways in cancer
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5222: Small cell lung cancer

PubMed abstracts associated with PTEN

PMID Title Tumor Value
14624456 Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells. yes no
17611696 Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. no no
18704985 Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors. yes no
21617855 Caffeine activates tumor suppressor PTEN in sarcoma cells. no no
21826611 Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. no no
23133552 Modulation of the osteosarcoma expression phenotype by microRNAs. yes no
title all all