General Information
Gene ID | 5728 |
---|---|
Gene Symbol | PTEN |
Gene Name | phosphatase and tensin homolog |
Gene Type | protein-coding |
Cytoband | 10q23.3 |
Ensembl ID | ENSG00000171862 |
#miR regulators | 17 |
Omim ID | 153480 155600 158350 176807 188470 275355 276950 601728 605309 607174 608089 613028 |
Gene ontology |
GO:0000079: regulation of cyclin-dependent protein serine/threonine kinase activity GO:0001525: angiogenesis GO:0001933: negative regulation of protein phosphorylation GO:0002902: regulation of B cell apoptotic process GO:0006915: apoptotic process GO:0006470: protein dephosphorylation GO:0006644: phospholipid metabolic process GO:0006661: phosphatidylinositol biosynthetic process GO:0007092: activation of mitotic anaphase-promoting complex activity GO:0007173: epidermal growth factor receptor signaling pathway GO:0007270: neuron-neuron synaptic transmission GO:0007416: synapse assembly GO:0007417: central nervous system development GO:0007507: heart development GO:0007611: learning or memory GO:0007626: locomotory behavior GO:0043066: negative regulation of apoptotic process GO:0008283: cell proliferation GO:0008284: positive regulation of cell proliferation GO:0008285: negative regulation of cell proliferation GO:0008543: fibroblast growth factor receptor signaling pathway GO:0010975: regulation of neuron projection development GO:0014067: negative regulation of phosphatidylinositol 3-kinase cascade GO:0016477: cell migration GO:0050821: protein stabilization GO:0048015: phosphatidylinositol-mediated signaling GO:0021542: dentate gyrus development GO:0021955: central nervous system neuron axonogenesis GO:0050852: T cell receptor signaling pathway GO:0030336: negative regulation of cell migration GO:0031642: negative regulation of myelination GO:0031647: regulation of protein stability GO:0031658: negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0032286: central nervous system myelin maintenance GO:0032535: regulation of cellular component size GO:0033032: regulation of myeloid cell apoptotic process GO:0033555: multicellular organismal response to stress GO:0035176: social behavior GO:0035335: peptidyl-tyrosine dephosphorylation GO:0038095: Fc-epsilon receptor signaling pathway GO:0042711: maternal behavior GO:0043491: protein kinase B signaling cascade GO:0043542: endothelial cell migration GO:0043647: inositol phosphate metabolic process GO:0044281: small molecule metabolic process GO:0045087: innate immune response GO:0045475: locomotor rhythm GO:0045792: negative regulation of cell size GO:0046621: negative regulation of organ growth GO:0046855: inositol phosphate dephosphorylation GO:0046856: phosphatidylinositol dephosphorylation GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048738: cardiac muscle tissue development GO:0048853: forebrain morphogenesis GO:0048854: brain morphogenesis GO:0050680: negative regulation of epithelial cell proliferation GO:0050771: negative regulation of axonogenesis GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity GO:0051895: negative regulation of focal adhesion assembly GO:0051898: negative regulation of protein kinase B signaling cascade GO:0060024: rhythmic synaptic transmission GO:0060070: canonical Wnt receptor signaling pathway GO:0060074: synapse maturation GO:0060134: prepulse inhibition GO:0060179: male mating behavior GO:0060291: long-term synaptic potentiation GO:0060736: prostate gland growth GO:0060997: dendritic spine morphogenesis GO:0061002: negative regulation of dendritic spine morphogenesis GO:0090071: negative regulation of ribosome biogenesis GO:0090344: negative regulation of cell aging GO:0090394: negative regulation of excitatory postsynaptic membrane potential GO:0097105: presynaptic membrane assembly GO:0097107: postsynaptic density assembly GO:2000060: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000134: negative regulation of G1/S transition of mitotic cell cycle GO:2000463: positive regulation of excitatory postsynaptic membrane potential GO:2000808: negative regulation of synaptic vesicle clustering GO:0005886: plasma membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0009898: internal side of plasma membrane GO:0016605: PML body GO:0043005: neuron projection GO:0035749: myelin sheath adaxonal region GO:0042995: cell projection GO:0043220: Schmidt-Lanterman incisure GO:0005515: protein binding GO:0000287: magnesium ion binding GO:0004438: phosphatidylinositol-3-phosphatase activity GO:0004721: phosphoprotein phosphatase activity GO:0004722: protein serine/threonine phosphatase activity GO:0004725: protein tyrosine phosphatase activity GO:0008289: lipid binding GO:0008138: protein tyrosine/serine/threonine phosphatase activity GO:0010997: anaphase-promoting complex binding GO:0016314: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity GO:0019899: enzyme binding GO:0019901: protein kinase binding GO:0030165: PDZ domain binding GO:0051717: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity GO:0051800: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity |
KEGG pathways |
562: Inositol phosphate metabolism 4070: Phosphatidylinositol signaling system 4115: p53 signaling pathway 4510: Focal adhesion 4530: Tight junction 5200: Pathways in cancer 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5218: Melanoma 5222: Small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
14624456 | Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells. | yes | no |
17611696 | Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. | no | no |
18704985 | Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors. | yes | no |
21617855 | Caffeine activates tumor suppressor PTEN in sarcoma cells. | no | no |
21826611 | Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. | no | no |
23133552 | Modulation of the osteosarcoma expression phenotype by microRNAs. | yes | no |
title | all | all |