Results for PTGS2

General Information

Gene ID 5743
Gene Symbol PTGS2
Gene Name prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Gene Type protein-coding
Cytoband 1q25.2-q25.3
Ensembl ID ENSG00000073756
#miR regulators 7
Omim ID 600262
Gene ontology GO:0001516: prostaglandin biosynthetic process
GO:0001525: angiogenesis
GO:0006693: prostaglandin metabolic process
GO:0006928: cellular component movement
GO:0006954: inflammatory response
GO:0006979: response to oxidative stress
GO:0007566: embryo implantation
GO:0007612: learning
GO:0007613: memory
GO:0008217: regulation of blood pressure
GO:0008285: negative regulation of cell proliferation
GO:0045987: positive regulation of smooth muscle contraction
GO:0042493: response to drug
GO:0009750: response to fructose stimulus
GO:0010042: response to manganese ion
GO:0010226: response to lithium ion
GO:0010575: positive regulation vascular endothelial growth factor production
GO:0019233: sensory perception of pain
GO:0019369: arachidonic acid metabolic process
GO:0019371: cyclooxygenase pathway
GO:0019372: lipoxygenase pathway
GO:0071260: cellular response to mechanical stimulus
GO:0030282: bone mineralization
GO:0030728: ovulation
GO:0031394: positive regulation of prostaglandin biosynthetic process
GO:0031622: positive regulation of fever generation
GO:0031915: positive regulation of synaptic plasticity
GO:0032227: negative regulation of synaptic transmission, dopaminergic
GO:0032355: response to estradiol stimulus
GO:0032496: response to lipopolysaccharide
GO:0033280: response to vitamin D
GO:0034612: response to tumor necrosis factor
GO:0034644: cellular response to UV
GO:0035633: maintenance of blood-brain barrier
GO:0042346: positive regulation of NF-kappaB import into nucleus
GO:0042640: anagen
GO:0043065: positive regulation of apoptotic process
GO:0044281: small molecule metabolic process
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0045786: negative regulation of cell cycle
GO:0045907: positive regulation of vasoconstriction
GO:0045986: negative regulation of smooth muscle contraction
GO:0046697: decidualization
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0050727: regulation of inflammatory response
GO:0050873: brown fat cell differentiation
GO:0051384: response to glucocorticoid stimulus
GO:0051926: negative regulation of calcium ion transport
GO:0051968: positive regulation of synaptic transmission, glutamatergic
GO:0070542: response to fatty acid
GO:0071318: cellular response to ATP
GO:0071456: cellular response to hypoxia
GO:0071636: positive regulation of transforming growth factor beta production
GO:0090050: positive regulation of cell migration involved in sprouting angiogenesis
GO:0090271: positive regulation of fibroblast growth factor production
GO:0090336: positive regulation of brown fat cell differentiation
GO:0090362: positive regulation of platelet-derived growth factor production
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005789: endoplasmic reticulum membrane
GO:0043005: neuron projection
GO:0043234: protein complex
GO:0004601: peroxidase activity
GO:0004666: prostaglandin-endoperoxide synthase activity
GO:0046872: metal ion binding
GO:0008289: lipid binding
GO:0019899: enzyme binding
GO:0020037: heme binding
GO:0042803: protein homodimerization activity
GO:0050473: arachidonate 15-lipoxygenase activity
KEGG pathways 590: Arachidonic acid metabolism
1100: Metabolic pathways
4370: VEGF signaling pathway
5140: Leishmaniasis
5200: Pathways in cancer
5222: Small cell lung cancer

PubMed abstracts associated with PTGS2

PMID Title Tumor Value
10896792 The regulation of PGE(2) biosynthesis in MG-63 osteosarcoma cells by IL-1 and FGF is cell density-dependent. no no
11179483 Dose-dependent modulation of apoptosis and cyclooxygenase-2 expression in human 1547 osteosarcoma cells by NS-398, a selective cyclooxygenase-2 inhibitor. no no
12024286 Cyclooxygenase-2 expression in pediatric sarcomas. yes no
12679640 Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. yes no
15067366 The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. no no
15144225 Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway. no no
15289892 A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. no no
15516323 Effect of TNF-alpha on human osteosarcoma cell line Saos2--TNF-alpha regulation of bone sialoprotein gene expression in Saos2 osteoblast-like cells. no no
16219634 Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. no no
16818639 Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. no no
16822878 Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma. yes yes
16956425 Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells. no no
17395421 Synergistic effects of meloxicam and conventional cytotoxic drugs in human MG-63 osteosarcoma cells. no no
17536311 Expression of cyclooxygenase-2 in osteosarcoma of bone. yes yes
17934334 Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. no no
18797196 COX-2 expression correlates with survival in patients with osteosarcoma lung metastases. yes yes
19326179 Cyclooxygenase-2 overexpression predicts poor survival in patients with high-grade extremity osteosarcoma: a pilot study. yes yes
21145881 Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathways. no no
21236332 15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. no no
21240382 Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. yes yes
21375766 RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion and migration of SaOS2 human osteosarcoma cells: a case control study. no no
22546756 Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. no no
22870593 Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas. yes yes
22922684 The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. yes no
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