General Information
Gene ID | 5745 |
---|---|
Gene Symbol | PTH1R |
Gene Name | parathyroid hormone 1 receptor |
Gene Type | protein-coding |
Cytoband | 3p22-p21.1 |
Ensembl ID | ENSG00000160801 |
#miR regulators | 4 |
Omim ID | 125350 156400 168468 215045 600002 |
Gene ontology |
GO:0001501: skeletal system development GO:0002062: chondrocyte differentiation GO:0002076: osteoblast development GO:0007186: G-protein coupled receptor signaling pathway GO:0007187: G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188: adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189: adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007200: phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204: elevation of cytosolic calcium ion concentration GO:0007568: aging GO:0008284: positive regulation of cell proliferation GO:0008285: negative regulation of cell proliferation GO:0030282: bone mineralization GO:0045453: bone resorption GO:0048469: cell maturation GO:0060732: positive regulation of inositol phosphate biosynthetic process GO:0005886: plasma membrane GO:0005887: integral to plasma membrane GO:0005634: nucleus GO:0005737: cytoplasm GO:0016323: basolateral plasma membrane GO:0016324: apical plasma membrane GO:0031526: brush border membrane GO:0043235: receptor complex GO:0004991: parathyroid hormone receptor activity GO:0017046: peptide hormone binding GO:0043621: protein self-association |
KEGG pathways |
4080: Neuroactive ligand-receptor interaction |
PMID | Title | Tumor | Value |
---|---|---|---|
16475708 | Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. | no | no |
17410535 | Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. | yes | no |
20156969 | Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues. | yes | no |
title | all | all |