Results for PTK2

General Information

Gene ID 5747
Gene Symbol PTK2
Gene Name protein tyrosine kinase 2
Gene Type protein-coding
Cytoband 8q24.3
Ensembl ID ENSG00000169398
#miR regulators 8
Omim ID 600758
Gene ontology GO:0000226: microtubule cytoskeleton organization
GO:0001525: angiogenesis
GO:0001570: vasculogenesis
GO:0001764: neuron migration
GO:0001890: placenta development
GO:0001934: positive regulation of protein phosphorylation
GO:0003007: heart morphogenesis
GO:0007596: blood coagulation
GO:0006915: apoptotic process
GO:0006921: cellular component disassembly involved in execution phase of apoptosis
GO:0009612: response to mechanical stimulus
GO:0030010: establishment of cell polarity
GO:0007172: signal complex assembly
GO:0007229: integrin-mediated signaling pathway
GO:0007254: JNK cascade
GO:0009790: embryo development
GO:0007411: axon guidance
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0008360: regulation of cell shape
GO:0045909: positive regulation of vasodilation
GO:0042493: response to drug
GO:0009749: response to glucose stimulus
GO:0010594: regulation of endothelial cell migration
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0014911: positive regulation of smooth muscle cell migration
GO:0046685: response to arsenic-containing substance
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0021955: central nervous system neuron axonogenesis
GO:0022408: negative regulation of cell-cell adhesion
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0030307: positive regulation of cell growth
GO:0030335: positive regulation of cell migration
GO:0030336: negative regulation of cell migration
GO:0030644: cellular chloride ion homeostasis
GO:0032319: regulation of Rho GTPase activity
GO:0032355: response to estradiol stimulus
GO:0033628: regulation of cell adhesion mediated by integrin
GO:0038007: netrin-activated signaling pathway
GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040023: establishment of nucleus localization
GO:0042127: regulation of cell proliferation
GO:0043542: endothelial cell migration
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087: innate immune response
GO:0045444: fat cell differentiation
GO:0045667: regulation of osteoblast differentiation
GO:0045785: positive regulation of cell adhesion
GO:0045860: positive regulation of protein kinase activity
GO:0046621: negative regulation of organ growth
GO:0046777: protein autophosphorylation
GO:0048013: ephrin receptor signaling pathway
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0048870: cell motility
GO:0050766: positive regulation of phagocytosis
GO:0050771: negative regulation of axonogenesis
GO:0050806: positive regulation of synaptic transmission
GO:0051493: regulation of cytoskeleton organization
GO:0051893: regulation of focal adhesion assembly
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0051964: negative regulation of synapse assembly
GO:0060252: positive regulation of glial cell proliferation
GO:0060396: growth hormone receptor signaling pathway
GO:2000060: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811: negative regulation of anoikis
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005730: nucleolus
GO:0005815: microtubule organizing center
GO:0005856: cytoskeleton
GO:0005925: focal adhesion
GO:0005938: cell cortex
GO:0014704: intercalated disc
GO:0016323: basolateral plasma membrane
GO:0016324: apical plasma membrane
GO:0016604: nuclear body
GO:0030027: lamellipodium
GO:0042383: sarcolemma
GO:0005515: protein binding
GO:0003779: actin binding
GO:0004672: protein kinase activity
GO:0004715: non-membrane spanning protein tyrosine kinase activity
GO:0004871: signal transducer activity
GO:0005178: integrin binding
GO:0005524: ATP binding
GO:0008432: JUN kinase binding
GO:0019901: protein kinase binding
GO:0042169: SH2 domain binding
GO:0043548: phosphatidylinositol 3-kinase binding
KEGG pathways 4012: ErbB signaling pathway
4062: Chemokine signaling pathway
4360: Axon guidance
4370: VEGF signaling pathway
4510: Focal adhesion
4670: Leukocyte transendothelial migration
4810: Regulation of actin cytoskeleton
5100: Bacterial invasion of epithelial cells
5146: Amoebiasis
5200: Pathways in cancer
5222: Small cell lung cancer

PubMed abstracts associated with PTK2

PMID Title Tumor Value
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no
21056138 Extracellular pressure stimulates adhesion of sarcoma cells via activation of focal adhesion kinase and Akt. no no
21421073 Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity. no no
22147650 Prion proteins (PRNP and PRND) are over-expressed in osteosarcoma. yes no
22158627 Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility. no no
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