Results for PTPN6

General Information

Gene ID 5777
Gene Symbol PTPN6
Gene Name protein tyrosine phosphatase, non-receptor type 6
Gene Type protein-coding
Cytoband 12p13
Ensembl ID ENSG00000111679 ENSG00000268954
#miR regulators ---
Omim ID 176883
Gene ontology GO:0002924: negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0007596: blood coagulation
GO:0006915: apoptotic process
GO:0006470: protein dephosphorylation
GO:0007186: G-protein coupled receptor signaling pathway
GO:0042267: natural killer cell mediated cytotoxicity
GO:0008283: cell proliferation
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0019221: cytokine-mediated signaling pathway
GO:0030154: cell differentiation
GO:0031295: T cell costimulation
GO:0042130: negative regulation of T cell proliferation
GO:0043407: negative regulation of MAP kinase activity
GO:0045577: regulation of B cell differentiation
GO:0050732: negative regulation of peptidyl-tyrosine phosphorylation
GO:0050853: B cell receptor signaling pathway
GO:0050860: negative regulation of T cell receptor signaling pathway
GO:0050900: leukocyte migration
GO:0060333: interferon-gamma-mediated signaling pathway
GO:0060334: regulation of interferon-gamma-mediated signaling pathway
GO:0060337: type I interferon-mediated signaling pathway
GO:0060338: regulation of type I interferon-mediated signaling pathway
GO:0060397: JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070372: regulation of ERK1 and ERK2 cascade
GO:2000045: regulation of G1/S transition of mitotic cell cycle
GO:0016020: membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0042105: alpha-beta T cell receptor complex
GO:0005515: protein binding
GO:0001784: phosphotyrosine binding
GO:0004725: protein tyrosine phosphatase activity
GO:0005001: transmembrane receptor protein tyrosine phosphatase activity
GO:0017124: SH3 domain binding
GO:0019901: protein kinase binding
GO:0042169: SH2 domain binding
KEGG pathways 4520: Adherens junction
4630: Jak-STAT signaling pathway
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
5140: Leishmaniasis

PubMed abstracts associated with PTPN6

PMID Title Tumor Value
22926753 SC-1, a sorafenib derivative, shows anti-tumor effects in osteogenic sarcoma cells. no no
title all all