General Information
Gene ID | 5777 |
---|---|
Gene Symbol | PTPN6 |
Gene Name | protein tyrosine phosphatase, non-receptor type 6 |
Gene Type | protein-coding |
Cytoband | 12p13 |
Ensembl ID | ENSG00000111679 ENSG00000268954 |
#miR regulators | --- |
Omim ID | 176883 |
Gene ontology |
GO:0002924: negative regulation of humoral immune response mediated by circulating immunoglobulin GO:0007596: blood coagulation GO:0006915: apoptotic process GO:0006470: protein dephosphorylation GO:0007186: G-protein coupled receptor signaling pathway GO:0042267: natural killer cell mediated cytotoxicity GO:0008283: cell proliferation GO:0008284: positive regulation of cell proliferation GO:0008285: negative regulation of cell proliferation GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade GO:0018108: peptidyl-tyrosine phosphorylation GO:0019221: cytokine-mediated signaling pathway GO:0030154: cell differentiation GO:0031295: T cell costimulation GO:0042130: negative regulation of T cell proliferation GO:0043407: negative regulation of MAP kinase activity GO:0045577: regulation of B cell differentiation GO:0050732: negative regulation of peptidyl-tyrosine phosphorylation GO:0050853: B cell receptor signaling pathway GO:0050860: negative regulation of T cell receptor signaling pathway GO:0050900: leukocyte migration GO:0060333: interferon-gamma-mediated signaling pathway GO:0060334: regulation of interferon-gamma-mediated signaling pathway GO:0060337: type I interferon-mediated signaling pathway GO:0060338: regulation of type I interferon-mediated signaling pathway GO:0060397: JAK-STAT cascade involved in growth hormone signaling pathway GO:0070372: regulation of ERK1 and ERK2 cascade GO:2000045: regulation of G1/S transition of mitotic cell cycle GO:0016020: membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0042105: alpha-beta T cell receptor complex GO:0005515: protein binding GO:0001784: phosphotyrosine binding GO:0004725: protein tyrosine phosphatase activity GO:0005001: transmembrane receptor protein tyrosine phosphatase activity GO:0017124: SH3 domain binding GO:0019901: protein kinase binding GO:0042169: SH2 domain binding |
KEGG pathways |
4520: Adherens junction 4630: Jak-STAT signaling pathway 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 5140: Leishmaniasis |
PMID | Title | Tumor | Value |
---|---|---|---|
22926753 | SC-1, a sorafenib derivative, shows anti-tumor effects in osteogenic sarcoma cells. | no | no |
title | all | all |