Results for BAX

General Information

Gene ID 581
Gene Symbol BAX
Gene Name BCL2-associated X protein
Gene Type protein-coding
Cytoband 19q13.3-q13.4
Ensembl ID ENSG00000087088
#miR regulators 3
Omim ID 600040
Gene ontology GO:0001101: response to acid
GO:0001541: ovarian follicle development
GO:0001764: neuron migration
GO:0001777: T cell homeostatic proliferation
GO:0001782: B cell homeostasis
GO:0001783: B cell apoptotic process
GO:0001822: kidney development
GO:0001836: release of cytochrome c from mitochondria
GO:0001844: protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001974: blood vessel remodeling
GO:0002262: myeloid cell homeostasis
GO:0002352: B cell negative selection
GO:0002358: B cell homeostatic proliferation
GO:0002904: positive regulation of B cell apoptotic process
GO:0051726: regulation of cell cycle
GO:0006915: apoptotic process
GO:0006309: apoptotic DNA fragmentation
GO:0006687: glycosphingolipid metabolic process
GO:0006808: regulation of nitrogen utilization
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006922: cleavage of lamin involved in execution phase of apoptosis
GO:0006927: transformed cell apoptotic process
GO:0006974: response to DNA damage stimulus
GO:0007281: germ cell development
GO:0008053: mitochondrial fusion
GO:0008635: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008637: apoptotic mitochondrial changes
GO:0009636: response to toxic substance
GO:0009566: fertilization
GO:0009651: response to salt stress
GO:0010248: establishment or maintenance of transmembrane electrochemical gradient
GO:0010332: response to gamma radiation
GO:0019048: modulation by virus of host morphology or physiology
GO:0021854: hypothalamus development
GO:0021987: cerebral cortex development
GO:0030264: nuclear fragmentation involved in apoptotic nuclear change
GO:0032091: negative regulation of protein binding
GO:0032461: positive regulation of protein oligomerization
GO:0032471: reduction of endoplasmic reticulum calcium ion concentration
GO:0032976: release of matrix enzymes from mitochondria
GO:0033137: negative regulation of peptidyl-serine phosphorylation
GO:0033599: regulation of mammary gland epithelial cell proliferation
GO:0034644: cellular response to UV
GO:0035108: limb morphogenesis
GO:0035234: germ cell programmed cell death
GO:0042475: odontogenesis of dentin-containing tooth
GO:0051260: protein homooligomerization
GO:0043065: positive regulation of apoptotic process
GO:0043496: regulation of protein homodimerization activity
GO:0043497: regulation of protein heterodimerization activity
GO:0043524: negative regulation of neuron apoptotic process
GO:0043525: positive regulation of neuron apoptotic process
GO:0043653: mitochondrial fragmentation involved in apoptotic process
GO:0045136: development of secondary sexual characteristics
GO:0046666: retinal cell programmed cell death
GO:0048087: positive regulation of developmental pigmentation
GO:0048147: negative regulation of fibroblast proliferation
GO:0048515: spermatid differentiation
GO:0048597: post-embryonic camera-type eye morphogenesis
GO:0048678: response to axon injury
GO:0048873: homeostasis of number of cells within a tissue
GO:0051259: protein oligomerization
GO:0051281: positive regulation of release of sequestered calcium ion into cytosol
GO:0051402: neuron apoptotic process
GO:0051881: regulation of mitochondrial membrane potential
GO:0060011: Sertoli cell proliferation
GO:0060041: retina development in camera-type eye
GO:0060058: positive regulation of apoptotic process involved in mammary gland involution
GO:0060068: vagina development
GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071310: cellular response to organic substance
GO:0090200: positive regulation of release of cytochrome c from mitochondria
GO:0097190: apoptotic signaling pathway
GO:0097191: extrinsic apoptotic signaling pathway
GO:0097193: intrinsic apoptotic signaling pathway
GO:1900103: positive regulation of endoplasmic reticulum unfolded protein response
GO:1901030: positive regulation of mitochondrial outer membrane permeabilization
GO:1990009: retinal cell apoptotic process
GO:1990117: B cell receptor apoptotic signaling pathway
GO:2001244: positive regulation of intrinsic apoptotic signaling pathway
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005783: endoplasmic reticulum
GO:0005634: nucleus
GO:0005741: mitochondrial outer membrane
GO:0005757: mitochondrial permeability transition pore complex
GO:0005789: endoplasmic reticulum membrane
GO:0046930: pore complex
GO:0097136: Bcl-2 family protein complex
GO:0005515: protein binding
GO:0008289: lipid binding
GO:0042802: identical protein binding
GO:0015267: channel activity
GO:0042803: protein homodimerization activity
GO:0046982: protein heterodimerization activity
GO:0051434: BH3 domain binding
KEGG pathways 4115: p53 signaling pathway
4141: Protein processing in endoplasmic reticulum
4210: Apoptosis
4722: Neurotrophin signaling pathway
5014: Amyotrophic lateral sclerosis (ALS)
5016: Huntington's disease
5020: Prion diseases
5200: Pathways in cancer
5210: Colorectal cancer

PubMed abstracts associated with BAX

PMID Title Tumor Value
8616838 Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. no no
10232607 Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. no no
10571205 A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. no no
11513857 The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells. no no
12478472 Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response. no no
15662138 The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells. no no
15827336 p53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome. no no
15936998 Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. no no
16026999 Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells. no no
16167336 Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. no no
16213662 Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. no no
16219634 Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. no no
16466985 Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin. no no
16797629 Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. no no
17218778 Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. no no
17234448 Modulation of apoptotic signalling by 9-hydroxystearic acid in osteosarcoma cells. no no
17342313 Bax gene therapy for human osteosarcoma using cationic liposomes in vivo. no no
17356895 Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. no no
17395421 Synergistic effects of meloxicam and conventional cytotoxic drugs in human MG-63 osteosarcoma cells. no no
17471233 Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. no no
17520676 Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. no no
17611411 P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner. no no
17959036 Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. no no
18158779 Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. yes yes
18161867 Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. yes yes
18223689 Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. no no
18606492 The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. no no
19757179 beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. no no
19818735 Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing. no no
19894220 Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma. no no
20053387 RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. no no
20357441 Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line. no no
20376536 Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. no no
21163271 Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. no no
21234653 Anti-tumor effects of dihydroartemisinin on human osteosarcoma. no no
21240382 Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. yes yes
21287809 Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. no no
21331449 Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. no no
21490307 The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. no no
21573491 Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. no no
21617882 Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. no no
21717192 Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. no no
21805050 Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. no no
21822538 p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. no no
21993662 Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. no no
22009832 Apoptotic effects of curcumin on human osteosarcoma U2OS cells. no no
22126901 Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. no no
22231496 Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. no no
22246399 Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. no no
22422053 Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. no no
22674530 Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. no no
23164673 The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. no no
23313376 Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. no no
23451817 Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. no no
23266503 Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. no no
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