General Information
Gene ID | 581 |
---|---|
Gene Symbol | BAX |
Gene Name | BCL2-associated X protein |
Gene Type | protein-coding |
Cytoband | 19q13.3-q13.4 |
Ensembl ID | ENSG00000087088 |
#miR regulators | 3 |
Omim ID | 600040 |
Gene ontology |
GO:0001101: response to acid GO:0001541: ovarian follicle development GO:0001764: neuron migration GO:0001777: T cell homeostatic proliferation GO:0001782: B cell homeostasis GO:0001783: B cell apoptotic process GO:0001822: kidney development GO:0001836: release of cytochrome c from mitochondria GO:0001844: protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001974: blood vessel remodeling GO:0002262: myeloid cell homeostasis GO:0002352: B cell negative selection GO:0002358: B cell homeostatic proliferation GO:0002904: positive regulation of B cell apoptotic process GO:0051726: regulation of cell cycle GO:0006915: apoptotic process GO:0006309: apoptotic DNA fragmentation GO:0006687: glycosphingolipid metabolic process GO:0006808: regulation of nitrogen utilization GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006922: cleavage of lamin involved in execution phase of apoptosis GO:0006927: transformed cell apoptotic process GO:0006974: response to DNA damage stimulus GO:0007281: germ cell development GO:0008053: mitochondrial fusion GO:0008635: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008637: apoptotic mitochondrial changes GO:0009636: response to toxic substance GO:0009566: fertilization GO:0009651: response to salt stress GO:0010248: establishment or maintenance of transmembrane electrochemical gradient GO:0010332: response to gamma radiation GO:0019048: modulation by virus of host morphology or physiology GO:0021854: hypothalamus development GO:0021987: cerebral cortex development GO:0030264: nuclear fragmentation involved in apoptotic nuclear change GO:0032091: negative regulation of protein binding GO:0032461: positive regulation of protein oligomerization GO:0032471: reduction of endoplasmic reticulum calcium ion concentration GO:0032976: release of matrix enzymes from mitochondria GO:0033137: negative regulation of peptidyl-serine phosphorylation GO:0033599: regulation of mammary gland epithelial cell proliferation GO:0034644: cellular response to UV GO:0035108: limb morphogenesis GO:0035234: germ cell programmed cell death GO:0042475: odontogenesis of dentin-containing tooth GO:0051260: protein homooligomerization GO:0043065: positive regulation of apoptotic process GO:0043496: regulation of protein homodimerization activity GO:0043497: regulation of protein heterodimerization activity GO:0043524: negative regulation of neuron apoptotic process GO:0043525: positive regulation of neuron apoptotic process GO:0043653: mitochondrial fragmentation involved in apoptotic process GO:0045136: development of secondary sexual characteristics GO:0046666: retinal cell programmed cell death GO:0048087: positive regulation of developmental pigmentation GO:0048147: negative regulation of fibroblast proliferation GO:0048515: spermatid differentiation GO:0048597: post-embryonic camera-type eye morphogenesis GO:0048678: response to axon injury GO:0048873: homeostasis of number of cells within a tissue GO:0051259: protein oligomerization GO:0051281: positive regulation of release of sequestered calcium ion into cytosol GO:0051402: neuron apoptotic process GO:0051881: regulation of mitochondrial membrane potential GO:0060011: Sertoli cell proliferation GO:0060041: retina development in camera-type eye GO:0060058: positive regulation of apoptotic process involved in mammary gland involution GO:0060068: vagina development GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0071310: cellular response to organic substance GO:0090200: positive regulation of release of cytochrome c from mitochondria GO:0097190: apoptotic signaling pathway GO:0097191: extrinsic apoptotic signaling pathway GO:0097193: intrinsic apoptotic signaling pathway GO:1900103: positive regulation of endoplasmic reticulum unfolded protein response GO:1901030: positive regulation of mitochondrial outer membrane permeabilization GO:1990009: retinal cell apoptotic process GO:1990117: B cell receptor apoptotic signaling pathway GO:2001244: positive regulation of intrinsic apoptotic signaling pathway GO:0005739: mitochondrion GO:0005829: cytosol GO:0005783: endoplasmic reticulum GO:0005634: nucleus GO:0005741: mitochondrial outer membrane GO:0005757: mitochondrial permeability transition pore complex GO:0005789: endoplasmic reticulum membrane GO:0046930: pore complex GO:0097136: Bcl-2 family protein complex GO:0005515: protein binding GO:0008289: lipid binding GO:0042802: identical protein binding GO:0015267: channel activity GO:0042803: protein homodimerization activity GO:0046982: protein heterodimerization activity GO:0051434: BH3 domain binding |
KEGG pathways |
4115: p53 signaling pathway 4141: Protein processing in endoplasmic reticulum 4210: Apoptosis 4722: Neurotrophin signaling pathway 5014: Amyotrophic lateral sclerosis (ALS) 5016: Huntington's disease 5020: Prion diseases 5200: Pathways in cancer 5210: Colorectal cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
8616838 | Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. | no | no |
10232607 | Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. | no | no |
10571205 | A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. | no | no |
11513857 | The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells. | no | no |
12478472 | Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response. | no | no |
15662138 | The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells. | no | no |
15827336 | p53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome. | no | no |
15936998 | Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. | no | no |
16026999 | Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells. | no | no |
16167336 | Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. | no | no |
16213662 | Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. | no | no |
16219634 | Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. | no | no |
16466985 | Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin. | no | no |
16797629 | Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. | no | no |
17218778 | Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. | no | no |
17234448 | Modulation of apoptotic signalling by 9-hydroxystearic acid in osteosarcoma cells. | no | no |
17342313 | Bax gene therapy for human osteosarcoma using cationic liposomes in vivo. | no | no |
17356895 | Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. | no | no |
17395421 | Synergistic effects of meloxicam and conventional cytotoxic drugs in human MG-63 osteosarcoma cells. | no | no |
17471233 | Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. | no | no |
17520676 | Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. | no | no |
17611411 | P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner. | no | no |
17959036 | Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. | no | no |
18158779 | Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. | yes | yes |
18161867 | Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. | yes | yes |
18223689 | Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. | no | no |
18606492 | The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. | no | no |
19757179 | beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. | no | no |
19818735 | Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing. | no | no |
19894220 | Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma. | no | no |
20053387 | RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. | no | no |
20357441 | Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line. | no | no |
20376536 | Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. | no | no |
21163271 | Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. | no | no |
21234653 | Anti-tumor effects of dihydroartemisinin on human osteosarcoma. | no | no |
21240382 | Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. | yes | yes |
21287809 | Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. | no | no |
21331449 | Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. | no | no |
21490307 | The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. | no | no |
21573491 | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | no | no |
21617882 | Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. | no | no |
21717192 | Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. | no | no |
21805050 | Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. | no | no |
21822538 | p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. | no | no |
21993662 | Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. | no | no |
22009832 | Apoptotic effects of curcumin on human osteosarcoma U2OS cells. | no | no |
22126901 | Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. | no | no |
22231496 | Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. | no | no |
22246399 | Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. | no | no |
22422053 | Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. | no | no |
22674530 | Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. | no | no |
23164673 | The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. | no | no |
23313376 | Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. | no | no |
23451817 | Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. | no | no |
23266503 | Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. | no | no |
title | all | all |