Results for RAF1

General Information

Gene ID 5894
Gene Symbol RAF1
Gene Name v-raf-1 murine leukemia viral oncogene homolog 1
Gene Type protein-coding
Cytoband 3p25
Ensembl ID ENSG00000132155
#miR regulators 11
Omim ID 164760 611553 611554
Gene ontology GO:0000165: MAPK cascade
GO:0000186: activation of MAPKK activity
GO:0001666: response to hypoxia
GO:0007596: blood coagulation
GO:0007010: cytoskeleton organization
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006468: protein phosphorylation
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007190: activation of adenylate cyclase activity
GO:0007264: small GTPase mediated signal transduction
GO:0007265: Ras protein signal transduction
GO:0007268: synaptic transmission
GO:0007411: axon guidance
GO:0007507: heart development
GO:0043066: negative regulation of apoptotic process
GO:0008283: cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0042981: regulation of apoptotic process
GO:0030168: platelet activation
GO:0031333: negative regulation of protein complex assembly
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0034220: ion transmembrane transport
GO:0035023: regulation of Rho protein signal transduction
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042060: wound healing
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087: innate immune response
GO:0045595: regulation of cell differentiation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0055085: transmembrane transport
GO:2000145: regulation of cell motility
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005741: mitochondrial outer membrane
GO:0031143: pseudopodium
GO:0005515: protein binding
GO:0004672: protein kinase activity
GO:0004674: protein serine/threonine kinase activity
GO:0004709: MAP kinase kinase kinase activity
GO:0046872: metal ion binding
GO:0005524: ATP binding
GO:0042802: identical protein binding
GO:0017016: Ras GTPase binding
GO:0031434: mitogen-activated protein kinase kinase binding
GO:0046982: protein heterodimerization activity
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4062: Chemokine signaling pathway
4270: Vascular smooth muscle contraction
4370: VEGF signaling pathway
4510: Focal adhesion
4540: Gap junction
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4666: Fc gamma R-mediated phagocytosis
4720: Long-term potentiation
4722: Neurotrophin signaling pathway
4730: Long-term depression
4810: Regulation of actin cytoskeleton
4910: Insulin signaling pathway
4912: GnRH signaling pathway
4914: Progesterone-mediated oocyte maturation
4916: Melanogenesis
5160: Hepatitis C
5200: Pathways in cancer
5210: Colorectal cancer
5211: Renal cell carcinoma
5212: Pancreatic cancer
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5223: Non-small cell lung cancer

PubMed abstracts associated with RAF1

PMID Title Tumor Value
2496060 Amplification of both c-myc and c-raf-1 oncogenes in a human osteosarcoma. yes no
21378337 The role of MAPK pathway in bone and soft tissue tumors. yes no
22935974 Mitogen-activated protein kinase pathway in osteosarcoma. yes yes
23507142 miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. yes no
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