General Information
| Gene ID | 5894 |
|---|---|
| Gene Symbol | RAF1 |
| Gene Name | v-raf-1 murine leukemia viral oncogene homolog 1 |
| Gene Type | protein-coding |
| Cytoband | 3p25 |
| Ensembl ID | ENSG00000132155 |
| #miR regulators | 11 |
| Omim ID | 164760 611553 611554 |
| Gene ontology |
GO:0000165: MAPK cascade GO:0000186: activation of MAPKK activity GO:0001666: response to hypoxia GO:0007596: blood coagulation GO:0007010: cytoskeleton organization GO:0006915: apoptotic process GO:0007165: signal transduction GO:0006468: protein phosphorylation GO:0007173: epidermal growth factor receptor signaling pathway GO:0007190: activation of adenylate cyclase activity GO:0007264: small GTPase mediated signal transduction GO:0007265: Ras protein signal transduction GO:0007268: synaptic transmission GO:0007411: axon guidance GO:0007507: heart development GO:0043066: negative regulation of apoptotic process GO:0008283: cell proliferation GO:0008285: negative regulation of cell proliferation GO:0008286: insulin receptor signaling pathway GO:0008543: fibroblast growth factor receptor signaling pathway GO:0042981: regulation of apoptotic process GO:0030168: platelet activation GO:0031333: negative regulation of protein complex assembly GO:0033138: positive regulation of peptidyl-serine phosphorylation GO:0034220: ion transmembrane transport GO:0035023: regulation of Rho protein signal transduction GO:0038095: Fc-epsilon receptor signaling pathway GO:0042060: wound healing GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045087: innate immune response GO:0045595: regulation of cell differentiation GO:0048011: neurotrophin TRK receptor signaling pathway GO:0055085: transmembrane transport GO:2000145: regulation of cell motility GO:0005886: plasma membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005741: mitochondrial outer membrane GO:0031143: pseudopodium GO:0005515: protein binding GO:0004672: protein kinase activity GO:0004674: protein serine/threonine kinase activity GO:0004709: MAP kinase kinase kinase activity GO:0046872: metal ion binding GO:0005524: ATP binding GO:0042802: identical protein binding GO:0017016: Ras GTPase binding GO:0031434: mitogen-activated protein kinase kinase binding GO:0046982: protein heterodimerization activity |
| KEGG pathways |
4010: MAPK signaling pathway 4012: ErbB signaling pathway 4062: Chemokine signaling pathway 4270: Vascular smooth muscle contraction 4370: VEGF signaling pathway 4510: Focal adhesion 4540: Gap junction 4650: Natural killer cell mediated cytotoxicity 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4664: Fc epsilon RI signaling pathway 4666: Fc gamma R-mediated phagocytosis 4720: Long-term potentiation 4722: Neurotrophin signaling pathway 4730: Long-term depression 4810: Regulation of actin cytoskeleton 4910: Insulin signaling pathway 4912: GnRH signaling pathway 4914: Progesterone-mediated oocyte maturation 4916: Melanogenesis 5160: Hepatitis C 5200: Pathways in cancer 5210: Colorectal cancer 5211: Renal cell carcinoma 5212: Pancreatic cancer 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5218: Melanoma 5219: Bladder cancer 5220: Chronic myeloid leukemia 5221: Acute myeloid leukemia 5223: Non-small cell lung cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 2496060 | Amplification of both c-myc and c-raf-1 oncogenes in a human osteosarcoma. | yes | no |
| 21378337 | The role of MAPK pathway in bone and soft tissue tumors. | yes | no |
| 22935974 | Mitogen-activated protein kinase pathway in osteosarcoma. | yes | yes |
| 23507142 | miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. | yes | no |
| title | all | all |