Results for RARA

General Information

Gene ID 5914
Gene Symbol RARA
Gene Name retinoic acid receptor, alpha
Gene Type protein-coding
Cytoband 17q21
Ensembl ID ENSG00000131759
#miR regulators 3
Omim ID 180240 612376
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001657: ureteric bud development
GO:0003417: growth plate cartilage development
GO:0007165: signal transduction
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0006468: protein phosphorylation
GO:0007281: germ cell development
GO:0007283: spermatogenesis
GO:0008284: positive regulation of cell proliferation
GO:0010467: gene expression
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0030520: intracellular estrogen receptor signaling pathway
GO:0030853: negative regulation of granulocyte differentiation
GO:0032355: response to estradiol stimulus
GO:0032526: response to retinoic acid
GO:0032689: negative regulation of interferon-gamma production
GO:0032720: negative regulation of tumor necrosis factor production
GO:0032736: positive regulation of interleukin-13 production
GO:0032753: positive regulation of interleukin-4 production
GO:0032754: positive regulation of interleukin-5 production
GO:0035264: multicellular organism growth
GO:0043277: apoptotic cell clearance
GO:0045630: positive regulation of T-helper 2 cell differentiation
GO:0045787: positive regulation of cell cycle
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0045947: negative regulation of translational initiation
GO:0048384: retinoic acid receptor signaling pathway
GO:0051099: positive regulation of binding
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0055012: ventricular cardiac muscle cell differentiation
GO:0060010: Sertoli cell fate commitment
GO:0060591: chondroblast differentiation
GO:0061037: negative regulation of cartilage development
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0071222: cellular response to lipopolysaccharide
GO:0071300: cellular response to retinoic acid
GO:0071391: cellular response to estrogen stimulus
GO:0000790: nuclear chromatin
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0009986: cell surface
GO:0030425: dendrite
GO:0043025: neuronal cell body
GO:0005515: protein binding
GO:0001972: retinoic acid binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003707: steroid hormone receptor activity
GO:0003708: retinoic acid receptor activity
GO:0003713: transcription coactivator activity
GO:0003714: transcription corepressor activity
GO:0005102: receptor binding
GO:0051018: protein kinase A binding
GO:0008134: transcription factor binding
GO:0008270: zinc ion binding
GO:0019899: enzyme binding
GO:0019904: protein domain specific binding
GO:0031490: chromatin DNA binding
GO:0035014: phosphatidylinositol 3-kinase regulator activity
GO:0043422: protein kinase B binding
GO:0043565: sequence-specific DNA binding
GO:0044323: retinoic acid-responsive element binding
GO:0046982: protein heterodimerization activity
KEGG pathways 5200: Pathways in cancer
5221: Acute myeloid leukemia

PubMed abstracts associated with RARA

PMID Title Tumor Value
20190807 Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells. no no
20371684 Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. no no
title all all