Results for RB1

General Information

Gene ID 5925
Gene Symbol RB1
Gene Name retinoblastoma 1
Gene Type protein-coding
Cytoband 13q14.2
Ensembl ID ENSG00000139687
#miR regulators 7
Omim ID 109800 180200 182280 259500 614041
Gene ontology GO:0000075: cell cycle checkpoint
GO:0000082: G1/S transition of mitotic cell cycle
GO:0000083: regulation of transcription involved in G1/S phase of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0006338: chromatin remodeling
GO:0006351: transcription, DNA-dependent
GO:0006469: negative regulation of protein kinase activity
GO:0007050: cell cycle arrest
GO:0007070: negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0007093: mitotic cell cycle checkpoint
GO:0007265: Ras protein signal transduction
GO:0007346: regulation of mitotic cell cycle
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0019048: modulation by virus of host morphology or physiology
GO:0030521: androgen receptor signaling pathway
GO:0031134: sister chromatid biorientation
GO:0031175: neuron projection development
GO:0034088: maintenance of mitotic sister chromatid cohesion
GO:0035914: skeletal muscle cell differentiation
GO:0042551: neuron maturation
GO:0043353: enucleate erythrocyte differentiation
GO:0043433: negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043550: regulation of lipid kinase activity
GO:0045445: myoblast differentiation
GO:0045651: positive regulation of macrophage differentiation
GO:0045842: positive regulation of mitotic metaphase/anaphase transition
GO:0045879: negative regulation of smoothened signaling pathway
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048565: digestive tract development
GO:0048667: cell morphogenesis involved in neuron differentiation
GO:0050680: negative regulation of epithelial cell proliferation
GO:0051301: cell division
GO:0051402: neuron apoptotic process
GO:0071459: protein localization to chromosome, centromeric region
GO:0071922: regulation of cohesin localization to chromatin
GO:0071930: negative regulation of transcription involved in G1/S phase of mitotic cell cycle
GO:0090230: regulation of centromere complex assembly
GO:2000134: negative regulation of G1/S transition of mitotic cell cycle
GO:0000785: chromatin
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005819: spindle
GO:0016514: SWI/SNF complex
GO:0016605: PML body
GO:0035189: Rb-E2F complex
GO:0005515: protein binding
GO:0001047: core promoter binding
GO:0001102: RNA polymerase II activating transcription factor binding
GO:0003677: DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003713: transcription coactivator activity
GO:0008134: transcription factor binding
GO:0042802: identical protein binding
GO:0019900: kinase binding
GO:0031625: ubiquitin protein ligase binding
GO:0050681: androgen receptor binding
GO:0051219: phosphoprotein binding
KEGG pathways 4110: Cell cycle
5200: Pathways in cancer
5212: Pancreatic cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5222: Small cell lung cancer
5223: Non-small cell lung cancer

PubMed abstracts associated with RB1

PMID Title Tumor Value
1388095 Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. no no
1423318 Analysis of a metastasizing testicular mixed gonadal stromal tumor with osteosarcoma components suggests that a malignant tumor with the histology of osteosarcoma may develop without primary involvement of RB1 and TP53. yes no
1524989 Studies of the RB1 gene and the p53 gene in human osteosarcomas. yes no
1568211 Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. yes no
1698437 Homozygous deletion within the retinoblastoma gene in a native osteosarcoma specimen of a patient cured of a retinoblastoma of both eyes. yes no
1884549 Involvement of the retinoblastoma gene in primary osteosarcomas and other bone and soft-tissue tumors. yes no
1988704 Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. yes no
2036639 Complete association of loss of heterozygosity of chromosomes 13 and 17 in osteosarcoma. yes no
2488230 Genetic analysis of childhood sarcoma. yes no
2740144 Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomas. yes no
2755701 Studies of the retinoblastoma gene in human sarcomas. yes no
2878716 Chromosome 13 instability and esterase D expression in an osteosarcoma cell line. no no
2898286 Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma. yes no
2918936 Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma. yes no
3162593 Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology. yes no
7513549 Chromosome analysis of nine osteosarcomas. yes no
7576109 Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. no no
7859736 Inhibition of apoptosis by the retinoblastoma gene product. no no
7926730 The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. no no
8187094 Mutation spectrum of the retinoblastoma gene in osteosarcomas. yes yes
8217129 An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma. yes no
8374897 Deletion of chromosome 13 in osteosarcoma secondary to irradiation. yes no
8507187 Translocation of retinoblastoma protein associated with tumor cell growth inhibition. no no
8513277 Alterations of retinoblastoma susceptible gene accompanied by c-myc amplification in human bone and soft tissue tumors. yes yes
8636759 Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. yes yes
8703379 Deletion of Rb1 gene in late osteosarcoma from survivor of unilateral retinoblastoma--a case report. yes no
8781571 Alterations of the p53, Rb and MDM2 genes in osteosarcoma. yes no
8866236 Loss of heterozygosity and microsatellite instability at the retinoblastoma locus in osteosarcomas. yes no
8891902 Oncogene alterations in primary, recurrent, and metastatic human bone tumors. yes yes
9136982 Differentiation induced by RB expression and apoptosis induced by p53 expression in an osteosarcoma cell line. no no
9154817 Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. no no
9355974 Altered G1 phase regulation in osteosarcoma. yes yes
9464545 Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. no no
9559293 Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas. yes no
9665476 CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. yes no
9685858 Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas. yes yes
9714336 p53-independent induction of WAF1/Cip1 is correlated with osteoblastic differentiation by vitamin D3. no no
9820862 Genetic instability in osteoblastic tumors of the skeletal system. yes no
9935200 CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. yes no
10234573 ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. no no
10339667 Expression of G1 phase regulators in MG-63 osteosarcoma cell line. no no
10502725 Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. yes yes
11115584 Osteosarcoma in blood relatives. yes no
11241308 Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. yes yes
11289134 Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. no no
11418138 pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. no no
11464280 Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. no no
11545733 The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. no no
11753985 Involvement of INK4A gene products in the pathogenesis and development of human osteosarcoma. yes yes
11943335 Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. no no
12759621 Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. yes yes
12789260 Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. no no
12799638 Genetic alterations in primary osteosarcoma from 54 children and adolescents by targeted allelotyping. yes no
12907249 Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. no no
14534726 Effect of retinoblastoma tumor suppressor gene expression on chemosensitivity of human osteosarcoma cell lines. no no
14559221 E2F decoy oligodeoxynucleotides effectively inhibit growth of human tumor cells. no no
14679136 Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. yes yes
15138564 Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. no no
15167009 Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma. yes yes
15455381 Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. no no
15538723 Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes. no no
15583032 Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. no no
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. no no
15883045 Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. no no
16696324 Effect of exogenous p16ink4a and hRb1 genes on cell cycle regulation of osteosarcoma cell. no no
17390023 Determination of the prognostic value of loss of heterozygosity at the retinoblastoma gene in osteosarcoma. yes no
18931939 Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. no no
19559722 Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. no no
20067614 Smoothened as a new therapeutic target for human osteosarcoma. yes no
20465837 Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy. yes yes
21506130 Role of GLI2 in the growth of human osteosarcoma. yes yes
22006429 High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. yes no
title all all