Results for BCL2

General Information

Gene ID 596
Gene Symbol BCL2
Gene Name B-cell CLL/lymphoma 2
Gene Type protein-coding
Cytoband 18q21.3
Ensembl ID ENSG00000171791
#miR regulators 12
Omim ID 151430
Gene ontology GO:0000082: G1/S transition of mitotic cell cycle
GO:0000209: protein polyubiquitination
GO:0001101: response to acid
GO:0001503: ossification
GO:0001541: ovarian follicle development
GO:0016049: cell growth
GO:0001656: metanephros development
GO:0001658: branching involved in ureteric bud morphogenesis
GO:0001662: behavioral fear response
GO:0001782: B cell homeostasis
GO:0001836: release of cytochrome c from mitochondria
GO:0001952: regulation of cell-matrix adhesion
GO:0002320: lymphoid progenitor cell differentiation
GO:0002326: B cell lineage commitment
GO:0003014: renal system process
GO:0006915: apoptotic process
GO:0006470: protein dephosphorylation
GO:0006582: melanin metabolic process
GO:0072593: reactive oxygen species metabolic process
GO:0006808: regulation of nitrogen utilization
GO:0006959: humoral immune response
GO:0006974: response to DNA damage stimulus
GO:0007015: actin filament organization
GO:0007409: axonogenesis
GO:0007565: female pregnancy
GO:0007569: cell aging
GO:0043066: negative regulation of apoptotic process
GO:0008219: cell death
GO:0008584: male gonad development
GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors
GO:0009314: response to radiation
GO:0042493: response to drug
GO:0009636: response to toxic substance
GO:0009605: response to external stimulus
GO:0009791: post-embryonic development
GO:0010039: response to iron ion
GO:0010224: response to UV-B
GO:0010332: response to gamma radiation
GO:0010507: negative regulation of autophagy
GO:0010523: negative regulation of calcium ion transport into cytosol
GO:0010559: regulation of glycoprotein biosynthetic process
GO:0014031: mesenchymal cell development
GO:0014042: positive regulation of neuron maturation
GO:0014911: positive regulation of smooth muscle cell migration
GO:0016337: cell-cell adhesion
GO:0018105: peptidyl-serine phosphorylation
GO:0018107: peptidyl-threonine phosphorylation
GO:0021747: cochlear nucleus development
GO:0022612: gland morphogenesis
GO:0022898: regulation of transmembrane transporter activity
GO:0030279: negative regulation of ossification
GO:0030307: positive regulation of cell growth
GO:0030308: negative regulation of cell growth
GO:0030318: melanocyte differentiation
GO:0030336: negative regulation of cell migration
GO:0030890: positive regulation of B cell proliferation
GO:0031069: hair follicle morphogenesis
GO:0031103: axon regeneration
GO:0031647: regulation of protein stability
GO:0032469: endoplasmic reticulum calcium ion homeostasis
GO:0032835: glomerulus development
GO:0032848: negative regulation of cellular pH reduction
GO:0033033: negative regulation of myeloid cell apoptotic process
GO:0033077: T cell differentiation in thymus
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0033689: negative regulation of osteoblast proliferation
GO:0034097: response to cytokine stimulus
GO:0035094: response to nicotine
GO:0035265: organ growth
GO:0035872: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0040018: positive regulation of multicellular organism growth
GO:0042100: B cell proliferation
GO:0042542: response to hydrogen peroxide
GO:0043029: T cell homeostasis
GO:0043085: positive regulation of catalytic activity
GO:0043375: CD8-positive, alpha-beta T cell lineage commitment
GO:0043496: regulation of protein homodimerization activity
GO:0043497: regulation of protein heterodimerization activity
GO:0043524: negative regulation of neuron apoptotic process
GO:0043583: ear development
GO:0045069: regulation of viral genome replication
GO:0045087: innate immune response
GO:0045636: positive regulation of melanocyte differentiation
GO:0045930: negative regulation of mitotic cell cycle
GO:0046671: negative regulation of retinal cell programmed cell death
GO:0046902: regulation of mitochondrial membrane permeability
GO:0048041: focal adhesion assembly
GO:0048536: spleen development
GO:0048538: thymus development
GO:0048546: digestive tract morphogenesis
GO:0048589: developmental growth
GO:0048599: oocyte development
GO:0048743: positive regulation of skeletal muscle fiber development
GO:0048753: pigment granule organization
GO:0048873: homeostasis of number of cells within a tissue
GO:0050853: B cell receptor signaling pathway
GO:0051384: response to glucocorticoid stimulus
GO:0051402: neuron apoptotic process
GO:0051607: defense response to virus
GO:0051881: regulation of mitochondrial membrane potential
GO:0051902: negative regulation of mitochondrial depolarization
GO:0051924: regulation of calcium ion transport
GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071310: cellular response to organic substance
GO:0097193: intrinsic apoptotic signaling pathway
GO:1900740: positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000811: negative regulation of anoikis
GO:2001234: negative regulation of apoptotic signaling pathway
GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243: negative regulation of intrinsic apoptotic signaling pathway
GO:2001244: positive regulation of intrinsic apoptotic signaling pathway
GO:0016020: membrane
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005783: endoplasmic reticulum
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005741: mitochondrial outer membrane
GO:0005789: endoplasmic reticulum membrane
GO:0046930: pore complex
GO:0031965: nuclear membrane
GO:0043209: myelin sheath
GO:0005515: protein binding
GO:0002020: protease binding
GO:0008134: transcription factor binding
GO:0042802: identical protein binding
GO:0015267: channel activity
GO:0016248: channel inhibitor activity
GO:0031625: ubiquitin protein ligase binding
GO:0042803: protein homodimerization activity
GO:0043565: sequence-specific DNA binding
GO:0046982: protein heterodimerization activity
GO:0051434: BH3 domain binding
GO:0051721: protein phosphatase 2A binding
KEGG pathways 4141: Protein processing in endoplasmic reticulum
4210: Apoptosis
4510: Focal adhesion
4722: Neurotrophin signaling pathway
5014: Amyotrophic lateral sclerosis (ALS)
5145: Toxoplasmosis
5200: Pathways in cancer
5210: Colorectal cancer
5215: Prostate cancer
5222: Small cell lung cancer

PubMed abstracts associated with BCL2

PMID Title Tumor Value
8959332 Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein. no no
10571205 A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. no no
11241246 Primary pulmonary osteosarcoma: case report and molecular analysis. yes no
12673693 Determination of a minimal region of loss of heterozygosity on chromosome 18q21.33 in osteosarcoma. yes no
15112275 Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. yes yes
15816563 Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells. no no
16026999 Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells. no no
16167336 Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. no no
16213662 Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. no no
16328036 Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro. no no
16466985 Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin. no no
16470222 RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. no no
16797629 Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. no no
17218778 Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. no no
17356895 Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. no no
17395421 Synergistic effects of meloxicam and conventional cytotoxic drugs in human MG-63 osteosarcoma cells. no no
17471233 Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. no no
17520676 Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. no no
17632732 Livin and Bcl-2 expression in high-grade osteosarcoma. yes yes
17959036 Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. no no
18161867 Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. yes yes
18675369 Bcl-2 and caspase-8 related anoikis resistance in human osteosarcoma MG-63 cells. no no
19160414 Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. no no
19746447 Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. no no
19757179 beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. no no
19818735 Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing. no no
20053387 RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. no no
20357441 Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line. no no
20376536 Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. no no
20460760 Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. no no
20580954 Functional and biological analysis of Bcl-xL expression in human osteosarcoma. yes no
20808934 Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. no no
20878132 microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2. yes no
21163271 Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. no no
21234653 Anti-tumor effects of dihydroartemisinin on human osteosarcoma. no no
21287809 Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. no no
21331449 Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. no no
21573491 Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. no no
21617882 Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. no no
21717192 Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. no no
21805050 Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. no no
21822538 p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. no no
21826611 Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. no no
21890444 Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. yes yes
21993662 Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. no no
22009832 Apoptotic effects of curcumin on human osteosarcoma U2OS cells. no no
22012179 Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling. no no
22126901 Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. no no
22231496 Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. no no
22246399 Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. no no
22674530 Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. no no
22715593 Overexpression of LIMK1 promotes migration ability of multidrug-resistant osteosarcoma cells. no no
23113351 The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression. no no
23164673 The glycogen synthase kinase-3?/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. no no
23208072 Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. no no
23322324 Effects of Kruppel-like factor 6 on osteosarcoma cell biological behavior. no no
23451817 Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. no no
23568006 Enhanced chemosensitivity by simultaneously inhibiting cell cycle progression and promoting apoptosis of drug-resistant osteosarcoma MG63/DXR cells by targeting Cyclin D1 and Bcl-2. no no
23266503 Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. no no
23403511 Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia. no no
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