General Information
Gene ID | 596 |
---|---|
Gene Symbol | BCL2 |
Gene Name | B-cell CLL/lymphoma 2 |
Gene Type | protein-coding |
Cytoband | 18q21.3 |
Ensembl ID | ENSG00000171791 |
#miR regulators | 12 |
Omim ID | 151430 |
Gene ontology |
GO:0000082: G1/S transition of mitotic cell cycle GO:0000209: protein polyubiquitination GO:0001101: response to acid GO:0001503: ossification GO:0001541: ovarian follicle development GO:0016049: cell growth GO:0001656: metanephros development GO:0001658: branching involved in ureteric bud morphogenesis GO:0001662: behavioral fear response GO:0001782: B cell homeostasis GO:0001836: release of cytochrome c from mitochondria GO:0001952: regulation of cell-matrix adhesion GO:0002320: lymphoid progenitor cell differentiation GO:0002326: B cell lineage commitment GO:0003014: renal system process GO:0006915: apoptotic process GO:0006470: protein dephosphorylation GO:0006582: melanin metabolic process GO:0072593: reactive oxygen species metabolic process GO:0006808: regulation of nitrogen utilization GO:0006959: humoral immune response GO:0006974: response to DNA damage stimulus GO:0007015: actin filament organization GO:0007409: axonogenesis GO:0007565: female pregnancy GO:0007569: cell aging GO:0043066: negative regulation of apoptotic process GO:0008219: cell death GO:0008584: male gonad development GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors GO:0009314: response to radiation GO:0042493: response to drug GO:0009636: response to toxic substance GO:0009605: response to external stimulus GO:0009791: post-embryonic development GO:0010039: response to iron ion GO:0010224: response to UV-B GO:0010332: response to gamma radiation GO:0010507: negative regulation of autophagy GO:0010523: negative regulation of calcium ion transport into cytosol GO:0010559: regulation of glycoprotein biosynthetic process GO:0014031: mesenchymal cell development GO:0014042: positive regulation of neuron maturation GO:0014911: positive regulation of smooth muscle cell migration GO:0016337: cell-cell adhesion GO:0018105: peptidyl-serine phosphorylation GO:0018107: peptidyl-threonine phosphorylation GO:0021747: cochlear nucleus development GO:0022612: gland morphogenesis GO:0022898: regulation of transmembrane transporter activity GO:0030279: negative regulation of ossification GO:0030307: positive regulation of cell growth GO:0030308: negative regulation of cell growth GO:0030318: melanocyte differentiation GO:0030336: negative regulation of cell migration GO:0030890: positive regulation of B cell proliferation GO:0031069: hair follicle morphogenesis GO:0031103: axon regeneration GO:0031647: regulation of protein stability GO:0032469: endoplasmic reticulum calcium ion homeostasis GO:0032835: glomerulus development GO:0032848: negative regulation of cellular pH reduction GO:0033033: negative regulation of myeloid cell apoptotic process GO:0033077: T cell differentiation in thymus GO:0033138: positive regulation of peptidyl-serine phosphorylation GO:0033689: negative regulation of osteoblast proliferation GO:0034097: response to cytokine stimulus GO:0035094: response to nicotine GO:0035265: organ growth GO:0035872: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0040018: positive regulation of multicellular organism growth GO:0042100: B cell proliferation GO:0042542: response to hydrogen peroxide GO:0043029: T cell homeostasis GO:0043085: positive regulation of catalytic activity GO:0043375: CD8-positive, alpha-beta T cell lineage commitment GO:0043496: regulation of protein homodimerization activity GO:0043497: regulation of protein heterodimerization activity GO:0043524: negative regulation of neuron apoptotic process GO:0043583: ear development GO:0045069: regulation of viral genome replication GO:0045087: innate immune response GO:0045636: positive regulation of melanocyte differentiation GO:0045930: negative regulation of mitotic cell cycle GO:0046671: negative regulation of retinal cell programmed cell death GO:0046902: regulation of mitochondrial membrane permeability GO:0048041: focal adhesion assembly GO:0048536: spleen development GO:0048538: thymus development GO:0048546: digestive tract morphogenesis GO:0048589: developmental growth GO:0048599: oocyte development GO:0048743: positive regulation of skeletal muscle fiber development GO:0048753: pigment granule organization GO:0048873: homeostasis of number of cells within a tissue GO:0050853: B cell receptor signaling pathway GO:0051384: response to glucocorticoid stimulus GO:0051402: neuron apoptotic process GO:0051607: defense response to virus GO:0051881: regulation of mitochondrial membrane potential GO:0051902: negative regulation of mitochondrial depolarization GO:0051924: regulation of calcium ion transport GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0071310: cellular response to organic substance GO:0097193: intrinsic apoptotic signaling pathway GO:1900740: positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:2000811: negative regulation of anoikis GO:2001234: negative regulation of apoptotic signaling pathway GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001243: negative regulation of intrinsic apoptotic signaling pathway GO:2001244: positive regulation of intrinsic apoptotic signaling pathway GO:0016020: membrane GO:0005739: mitochondrion GO:0005829: cytosol GO:0005783: endoplasmic reticulum GO:0005634: nucleus GO:0005737: cytoplasm GO:0005741: mitochondrial outer membrane GO:0005789: endoplasmic reticulum membrane GO:0046930: pore complex GO:0031965: nuclear membrane GO:0043209: myelin sheath GO:0005515: protein binding GO:0002020: protease binding GO:0008134: transcription factor binding GO:0042802: identical protein binding GO:0015267: channel activity GO:0016248: channel inhibitor activity GO:0031625: ubiquitin protein ligase binding GO:0042803: protein homodimerization activity GO:0043565: sequence-specific DNA binding GO:0046982: protein heterodimerization activity GO:0051434: BH3 domain binding GO:0051721: protein phosphatase 2A binding |
KEGG pathways |
4141: Protein processing in endoplasmic reticulum 4210: Apoptosis 4510: Focal adhesion 4722: Neurotrophin signaling pathway 5014: Amyotrophic lateral sclerosis (ALS) 5145: Toxoplasmosis 5200: Pathways in cancer 5210: Colorectal cancer 5215: Prostate cancer 5222: Small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
8959332 | Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein. | no | no |
10571205 | A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. | no | no |
11241246 | Primary pulmonary osteosarcoma: case report and molecular analysis. | yes | no |
12673693 | Determination of a minimal region of loss of heterozygosity on chromosome 18q21.33 in osteosarcoma. | yes | no |
15112275 | Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. | yes | yes |
15816563 | Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells. | no | no |
16026999 | Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells. | no | no |
16167336 | Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. | no | no |
16213662 | Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. | no | no |
16328036 | Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro. | no | no |
16466985 | Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin. | no | no |
16470222 | RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. | no | no |
16797629 | Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. | no | no |
17218778 | Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. | no | no |
17356895 | Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. | no | no |
17395421 | Synergistic effects of meloxicam and conventional cytotoxic drugs in human MG-63 osteosarcoma cells. | no | no |
17471233 | Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. | no | no |
17520676 | Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. | no | no |
17632732 | Livin and Bcl-2 expression in high-grade osteosarcoma. | yes | yes |
17959036 | Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. | no | no |
18161867 | Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. | yes | yes |
18675369 | Bcl-2 and caspase-8 related anoikis resistance in human osteosarcoma MG-63 cells. | no | no |
19160414 | Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. | no | no |
19746447 | Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. | no | no |
19757179 | beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. | no | no |
19818735 | Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing. | no | no |
20053387 | RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. | no | no |
20357441 | Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line. | no | no |
20376536 | Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. | no | no |
20460760 | Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. | no | no |
20580954 | Functional and biological analysis of Bcl-xL expression in human osteosarcoma. | yes | no |
20808934 | Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. | no | no |
20878132 | microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2. | yes | no |
21163271 | Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. | no | no |
21234653 | Anti-tumor effects of dihydroartemisinin on human osteosarcoma. | no | no |
21287809 | Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. | no | no |
21331449 | Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. | no | no |
21573491 | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | no | no |
21617882 | Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. | no | no |
21717192 | Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. | no | no |
21805050 | Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. | no | no |
21822538 | p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. | no | no |
21826611 | Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. | no | no |
21890444 | Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. | yes | yes |
21993662 | Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. | no | no |
22009832 | Apoptotic effects of curcumin on human osteosarcoma U2OS cells. | no | no |
22012179 | Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling. | no | no |
22126901 | Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. | no | no |
22231496 | Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. | no | no |
22246399 | Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. | no | no |
22674530 | Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. | no | no |
22715593 | Overexpression of LIMK1 promotes migration ability of multidrug-resistant osteosarcoma cells. | no | no |
23113351 | The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression. | no | no |
23164673 | The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. | no | no |
23208072 | Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. | no | no |
23322324 | Effects of Kruppel-like factor 6 on osteosarcoma cell biological behavior. | no | no |
23451817 | Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. | no | no |
23568006 | Enhanced chemosensitivity by simultaneously inhibiting cell cycle progression and promoting apoptosis of drug-resistant osteosarcoma MG63/DXR cells by targeting Cyclin D1 and Bcl-2. | no | no |
23266503 | Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. | no | no |
23403511 | Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia. | no | no |
title | all | all |