Results for RELA

General Information

Gene ID 5970
Gene Symbol RELA
Gene Name v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Gene Type protein-coding
Cytoband 11q13
Ensembl ID ENSG00000173039
#miR regulators 1
Omim ID 164014
Gene ontology GO:0001889: liver development
GO:0001942: hair follicle development
GO:0002224: toll-like receptor signaling pathway
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0006117: acetaldehyde metabolic process
GO:0009612: response to mechanical stimulus
GO:0006954: inflammatory response
GO:0006968: cellular defense response
GO:0009887: organ morphogenesis
GO:0007568: aging
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0042493: response to drug
GO:0010033: response to organic substance
GO:0010224: response to UV-B
GO:0014040: positive regulation of Schwann cell differentiation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0019048: modulation by virus of host morphology or physiology
GO:0019221: cytokine-mediated signaling pathway
GO:0050852: T cell receptor signaling pathway
GO:0031293: membrane protein intracellular domain proteolysis
GO:0032332: positive regulation of chondrocyte differentiation
GO:0032481: positive regulation of type I interferon production
GO:0032495: response to muramyl dipeptide
GO:0032570: response to progesterone stimulus
GO:0032868: response to insulin stimulus
GO:0033590: response to cobalamin
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0042177: negative regulation of protein catabolic process
GO:0042542: response to hydrogen peroxide
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043200: response to amino acid stimulus
GO:0043278: response to morphine
GO:0045084: positive regulation of interleukin-12 biosynthetic process
GO:0045087: innate immune response
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046627: negative regulation of insulin receptor signaling pathway
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0050727: regulation of inflammatory response
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051591: response to cAMP
GO:0051607: defense response to virus
GO:0070431: nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070555: response to interleukin-1
GO:0071222: cellular response to lipopolysaccharide
GO:0071347: cellular response to interleukin-1
GO:0071356: cellular response to tumor necrosis factor
GO:2001237: negative regulation of extrinsic apoptotic signaling pathway
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005515: protein binding
GO:0003677: DNA binding
GO:0003682: chromatin binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134: transcription factor binding
GO:0042802: identical protein binding
GO:0044212: transcription regulatory region DNA binding
GO:0019901: protein kinase binding
GO:0031625: ubiquitin protein ligase binding
GO:0032403: protein complex binding
GO:0033613: activating transcription factor binding
GO:0042301: phosphate ion binding
GO:0043565: sequence-specific DNA binding
GO:0047485: protein N-terminus binding
GO:0051059: NF-kappaB binding
GO:0070491: repressing transcription factor binding
GO:0071532: ankyrin repeat binding
KEGG pathways 4010: MAPK signaling pathway
4062: Chemokine signaling pathway
4210: Apoptosis
4380: Osteoclast differentiation
4620: Toll-like receptor signaling pathway
4621: NOD-like receptor signaling pathway
4622: RIG-I-like receptor signaling pathway
4623: Cytosolic DNA-sensing pathway
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4722: Neurotrophin signaling pathway
4920: Adipocytokine signaling pathway
5120: Epithelial cell signaling in Helicobacter pylori infection
5131: Shigellosis
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5145: Toxoplasmosis
5146: Amoebiasis
5160: Hepatitis C
5200: Pathways in cancer
5212: Pancreatic cancer
5215: Prostate cancer
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5222: Small cell lung cancer

PubMed abstracts associated with RELA

PMID Title Tumor Value
16797629 Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. no no
17611696 Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. no no
18598236 Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells. no no
19496172 Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. no no
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no
22886393 TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. yes no
23091618 Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. no no
23164673 The glycogen synthase kinase-3?/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. no no
title all all