General Information
Gene ID | 5970 |
---|---|
Gene Symbol | RELA |
Gene Name | v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
Gene Type | protein-coding |
Cytoband | 11q13 |
Ensembl ID | ENSG00000173039 |
#miR regulators | 1 |
Omim ID | 164014 |
Gene ontology |
GO:0001889: liver development GO:0001942: hair follicle development GO:0002224: toll-like receptor signaling pathway GO:0002755: MyD88-dependent toll-like receptor signaling pathway GO:0002756: MyD88-independent toll-like receptor signaling pathway GO:0006117: acetaldehyde metabolic process GO:0009612: response to mechanical stimulus GO:0006954: inflammatory response GO:0006968: cellular defense response GO:0009887: organ morphogenesis GO:0007568: aging GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0042493: response to drug GO:0010033: response to organic substance GO:0010224: response to UV-B GO:0014040: positive regulation of Schwann cell differentiation GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0019048: modulation by virus of host morphology or physiology GO:0019221: cytokine-mediated signaling pathway GO:0050852: T cell receptor signaling pathway GO:0031293: membrane protein intracellular domain proteolysis GO:0032332: positive regulation of chondrocyte differentiation GO:0032481: positive regulation of type I interferon production GO:0032495: response to muramyl dipeptide GO:0032570: response to progesterone stimulus GO:0032868: response to insulin stimulus GO:0033590: response to cobalamin GO:0034134: toll-like receptor 2 signaling pathway GO:0034138: toll-like receptor 3 signaling pathway GO:0034142: toll-like receptor 4 signaling pathway GO:0034146: toll-like receptor 5 signaling pathway GO:0034162: toll-like receptor 9 signaling pathway GO:0034166: toll-like receptor 10 signaling pathway GO:0035666: TRIF-dependent toll-like receptor signaling pathway GO:0038095: Fc-epsilon receptor signaling pathway GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway GO:0042177: negative regulation of protein catabolic process GO:0042542: response to hydrogen peroxide GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043200: response to amino acid stimulus GO:0043278: response to morphine GO:0045084: positive regulation of interleukin-12 biosynthetic process GO:0045087: innate immune response GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0046627: negative regulation of insulin receptor signaling pathway GO:0048011: neurotrophin TRK receptor signaling pathway GO:0050727: regulation of inflammatory response GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0051591: response to cAMP GO:0051607: defense response to virus GO:0070431: nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070555: response to interleukin-1 GO:0071222: cellular response to lipopolysaccharide GO:0071347: cellular response to interleukin-1 GO:0071356: cellular response to tumor necrosis factor GO:2001237: negative regulation of extrinsic apoptotic signaling pathway GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005667: transcription factor complex GO:0005515: protein binding GO:0003677: DNA binding GO:0003682: chromatin binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0008134: transcription factor binding GO:0042802: identical protein binding GO:0044212: transcription regulatory region DNA binding GO:0019901: protein kinase binding GO:0031625: ubiquitin protein ligase binding GO:0032403: protein complex binding GO:0033613: activating transcription factor binding GO:0042301: phosphate ion binding GO:0043565: sequence-specific DNA binding GO:0047485: protein N-terminus binding GO:0051059: NF-kappaB binding GO:0070491: repressing transcription factor binding GO:0071532: ankyrin repeat binding |
KEGG pathways |
4010: MAPK signaling pathway 4062: Chemokine signaling pathway 4210: Apoptosis 4380: Osteoclast differentiation 4620: Toll-like receptor signaling pathway 4621: NOD-like receptor signaling pathway 4622: RIG-I-like receptor signaling pathway 4623: Cytosolic DNA-sensing pathway 4660: T cell receptor signaling pathway 4662: B cell receptor signaling pathway 4722: Neurotrophin signaling pathway 4920: Adipocytokine signaling pathway 5120: Epithelial cell signaling in Helicobacter pylori infection 5131: Shigellosis 5140: Leishmaniasis 5142: Chagas disease (American trypanosomiasis) 5145: Toxoplasmosis 5146: Amoebiasis 5160: Hepatitis C 5200: Pathways in cancer 5212: Pancreatic cancer 5215: Prostate cancer 5220: Chronic myeloid leukemia 5221: Acute myeloid leukemia 5222: Small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
16797629 | Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. | no | no |
17611696 | Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. | no | no |
18598236 | Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells. | no | no |
19496172 | Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. | no | no |
22387266 | Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. | no | no |
22886393 | TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. | yes | no |
23091618 | Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. | no | no |
23164673 | The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. | no | no |
title | all | all |