Results for BCL2L1

General Information

Gene ID 598
Gene Symbol BCL2L1
Gene Name BCL2-like 1
Gene Type protein-coding
Cytoband 20q11.21
Ensembl ID ENSG00000171552
#miR regulators 3
Omim ID 600039
Gene ontology GO:0000910: cytokinesis
GO:0001541: ovarian follicle development
GO:0001701: in utero embryonic development
GO:0001836: release of cytochrome c from mitochondria
GO:0006915: apoptotic process
GO:0007093: mitotic cell cycle checkpoint
GO:0040007: growth
GO:0007281: germ cell development
GO:0007283: spermatogenesis
GO:0043066: negative regulation of apoptotic process
GO:0008283: cell proliferation
GO:0008284: positive regulation of cell proliferation
GO:0008584: male gonad development
GO:0008637: apoptotic mitochondrial changes
GO:0009566: fertilization
GO:0010507: negative regulation of autophagy
GO:0019050: suppression by virus of host apoptotic process
GO:0071230: cellular response to amino acid stimulus
GO:0034097: response to cytokine stimulus
GO:0035872: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043065: positive regulation of apoptotic process
GO:0043524: negative regulation of neuron apoptotic process
GO:0045087: innate immune response
GO:0046898: response to cycloheximide
GO:0046902: regulation of mitochondrial membrane permeability
GO:0051881: regulation of mitochondrial membrane potential
GO:0060154: cellular process regulating host cell cycle in response to virus
GO:0071312: cellular response to alkaloid
GO:0071480: cellular response to gamma radiation
GO:0090005: negative regulation of establishment of protein localization to plasma membrane
GO:0090201: negative regulation of release of cytochrome c from mitochondria
GO:0097193: intrinsic apoptotic signaling pathway
GO:1900118: negative regulation of execution phase of apoptosis
GO:1902230: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000811: negative regulation of anoikis
GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243: negative regulation of intrinsic apoptotic signaling pathway
GO:2001244: positive regulation of intrinsic apoptotic signaling pathway
GO:0016021: integral to membrane
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005737: cytoplasm
GO:0005741: mitochondrial outer membrane
GO:0005813: centrosome
GO:0031965: nuclear membrane
GO:0097136: Bcl-2 family protein complex
GO:0005515: protein binding
GO:0042802: identical protein binding
GO:0019901: protein kinase binding
GO:0046982: protein heterodimerization activity
GO:0051434: BH3 domain binding
KEGG pathways 4210: Apoptosis
4630: Jak-STAT signaling pathway
5014: Amyotrophic lateral sclerosis (ALS)
5145: Toxoplasmosis
5200: Pathways in cancer
5212: Pancreatic cancer
5220: Chronic myeloid leukemia
5222: Small cell lung cancer

PubMed abstracts associated with BCL2L1

PMID Title Tumor Value
10702275 Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. no no
17520676 Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. no no
20459702 Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. yes no
20580954 Functional and biological analysis of Bcl-xL expression in human osteosarcoma. yes no
21490307 The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. no no
21527497 Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. no no
22009832 Apoptotic effects of curcumin on human osteosarcoma U2OS cells. no no
22212432 Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells. no no
22743617 STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. no no
23313376 Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. no no
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