General Information
Gene ID | 5981 |
---|---|
Gene Symbol | RFC1 |
Gene Name | replication factor C (activator 1) 1, 145kDa |
Gene Type | protein-coding |
Cytoband | 4p14-p13 |
Ensembl ID | ENSG00000035928 |
#miR regulators | 9 |
Omim ID | 102579 |
Gene ontology |
GO:0000278: mitotic cell cycle GO:0000722: telomere maintenance via recombination GO:0000723: telomere maintenance GO:0006261: DNA-dependent DNA replication GO:0006271: DNA strand elongation involved in DNA replication GO:0006281: DNA repair GO:0006283: transcription-coupled nucleotide-excision repair GO:0006289: nucleotide-excision repair GO:0006297: nucleotide-excision repair, DNA gap filling GO:0006351: transcription, DNA-dependent GO:0006355: regulation of transcription, DNA-dependent GO:0007004: telomere maintenance via telomerase GO:0032201: telomere maintenance via semi-conservative replication GO:0043085: positive regulation of catalytic activity GO:0005654: nucleoplasm GO:0005663: DNA replication factor C complex GO:0005515: protein binding GO:0003689: DNA clamp loader activity GO:0005524: ATP binding GO:0008047: enzyme activator activity |
KEGG pathways |
3030: DNA replication 3420: Nucleotide excision repair 3430: Mismatch repair |
PMID | Title | Tumor | Value |
---|---|---|---|
10100715 | Mechanisms of methotrexate resistance in osteosarcoma. | yes | no |
12576457 | Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. | yes | no |
14582536 | Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques. | no | no |
19159907 | Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. | yes | no |
title | all | all |