Results for RFC1

General Information

Gene ID 5981
Gene Symbol RFC1
Gene Name replication factor C (activator 1) 1, 145kDa
Gene Type protein-coding
Cytoband 4p14-p13
Ensembl ID ENSG00000035928
#miR regulators 9
Omim ID 102579
Gene ontology GO:0000278: mitotic cell cycle
GO:0000722: telomere maintenance via recombination
GO:0000723: telomere maintenance
GO:0006261: DNA-dependent DNA replication
GO:0006271: DNA strand elongation involved in DNA replication
GO:0006281: DNA repair
GO:0006283: transcription-coupled nucleotide-excision repair
GO:0006289: nucleotide-excision repair
GO:0006297: nucleotide-excision repair, DNA gap filling
GO:0006351: transcription, DNA-dependent
GO:0006355: regulation of transcription, DNA-dependent
GO:0007004: telomere maintenance via telomerase
GO:0032201: telomere maintenance via semi-conservative replication
GO:0043085: positive regulation of catalytic activity
GO:0005654: nucleoplasm
GO:0005663: DNA replication factor C complex
GO:0005515: protein binding
GO:0003689: DNA clamp loader activity
GO:0005524: ATP binding
GO:0008047: enzyme activator activity
KEGG pathways 3030: DNA replication
3420: Nucleotide excision repair
3430: Mismatch repair

PubMed abstracts associated with RFC1

PMID Title Tumor Value
10100715 Mechanisms of methotrexate resistance in osteosarcoma. yes no
12576457 Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. yes no
14582536 Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques. no no
19159907 Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. yes no
title all all