General Information
Gene ID | 6093 |
---|---|
Gene Symbol | ROCK1 |
Gene Name | Rho-associated, coiled-coil containing protein kinase 1 |
Gene Type | protein-coding |
Cytoband | 18q11.1 |
Ensembl ID | ENSG00000067900 |
#miR regulators | 8 |
Omim ID | 601702 |
Gene ontology |
GO:0003383: apical constriction GO:0030036: actin cytoskeleton organization GO:0006915: apoptotic process GO:0007165: signal transduction GO:0006468: protein phosphorylation GO:0006921: cellular component disassembly involved in execution phase of apoptosis GO:0006939: smooth muscle contraction GO:0007159: leukocyte cell-cell adhesion GO:0007266: Rho protein signal transduction GO:0007411: axon guidance GO:0016525: negative regulation of angiogenesis GO:0022614: membrane to membrane docking GO:0030155: regulation of cell adhesion GO:0032060: bleb assembly GO:0032956: regulation of actin cytoskeleton organization GO:0043524: negative regulation of neuron apoptotic process GO:0045616: regulation of keratinocyte differentiation GO:0050900: leukocyte migration GO:0050901: leukocyte tethering or rolling GO:0051492: regulation of stress fiber assembly GO:0051893: regulation of focal adhesion assembly GO:2000114: regulation of establishment of cell polarity GO:2000145: regulation of cell motility GO:0005886: plasma membrane GO:0000139: Golgi membrane GO:0001726: ruffle GO:0005829: cytosol GO:0005814: centriole GO:0005856: cytoskeleton GO:0030027: lamellipodium GO:0032059: bleb GO:0005515: protein binding GO:0004672: protein kinase activity GO:0004674: protein serine/threonine kinase activity GO:0046872: metal ion binding GO:0005524: ATP binding GO:0005543: phospholipid binding GO:0017048: Rho GTPase binding |
KEGG pathways |
4062: Chemokine signaling pathway 4270: Vascular smooth muscle contraction 4310: Wnt signaling pathway 4350: TGF-beta signaling pathway 4360: Axon guidance 4510: Focal adhesion 4670: Leukocyte transendothelial migration 4810: Regulation of actin cytoskeleton 5130: Pathogenic Escherichia coli infection 5131: Shigellosis |
PMID | Title | Tumor | Value |
---|---|---|---|
21387396 | ROCK1 as a potential therapeutic target in osteosarcoma. | yes | no |
23872151 | MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1. | no | no |
title | all | all |