Results for ROCK1

General Information

Gene ID 6093
Gene Symbol ROCK1
Gene Name Rho-associated, coiled-coil containing protein kinase 1
Gene Type protein-coding
Cytoband 18q11.1
Ensembl ID ENSG00000067900
#miR regulators 8
Omim ID 601702
Gene ontology GO:0003383: apical constriction
GO:0030036: actin cytoskeleton organization
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006468: protein phosphorylation
GO:0006921: cellular component disassembly involved in execution phase of apoptosis
GO:0006939: smooth muscle contraction
GO:0007159: leukocyte cell-cell adhesion
GO:0007266: Rho protein signal transduction
GO:0007411: axon guidance
GO:0016525: negative regulation of angiogenesis
GO:0022614: membrane to membrane docking
GO:0030155: regulation of cell adhesion
GO:0032060: bleb assembly
GO:0032956: regulation of actin cytoskeleton organization
GO:0043524: negative regulation of neuron apoptotic process
GO:0045616: regulation of keratinocyte differentiation
GO:0050900: leukocyte migration
GO:0050901: leukocyte tethering or rolling
GO:0051492: regulation of stress fiber assembly
GO:0051893: regulation of focal adhesion assembly
GO:2000114: regulation of establishment of cell polarity
GO:2000145: regulation of cell motility
GO:0005886: plasma membrane
GO:0000139: Golgi membrane
GO:0001726: ruffle
GO:0005829: cytosol
GO:0005814: centriole
GO:0005856: cytoskeleton
GO:0030027: lamellipodium
GO:0032059: bleb
GO:0005515: protein binding
GO:0004672: protein kinase activity
GO:0004674: protein serine/threonine kinase activity
GO:0046872: metal ion binding
GO:0005524: ATP binding
GO:0005543: phospholipid binding
GO:0017048: Rho GTPase binding
KEGG pathways 4062: Chemokine signaling pathway
4270: Vascular smooth muscle contraction
4310: Wnt signaling pathway
4350: TGF-beta signaling pathway
4360: Axon guidance
4510: Focal adhesion
4670: Leukocyte transendothelial migration
4810: Regulation of actin cytoskeleton
5130: Pathogenic Escherichia coli infection
5131: Shigellosis

PubMed abstracts associated with ROCK1

PMID Title Tumor Value
21387396 ROCK1 as a potential therapeutic target in osteosarcoma. yes no
23872151 MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1. no no
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