Results for RPS6KB1

General Information

Gene ID 6198
Gene Symbol RPS6KB1
Gene Name ribosomal protein S6 kinase, 70kDa, polypeptide 1
Gene Type protein-coding
Cytoband 17q23.1
Ensembl ID ENSG00000108443
#miR regulators 12
Omim ID 608938
Gene ontology GO:0000082: G1/S transition of mitotic cell cycle
GO:0003009: skeletal muscle contraction
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006468: protein phosphorylation
GO:0009612: response to mechanical stimulus
GO:0007281: germ cell development
GO:0007568: aging
GO:0007584: response to nutrient
GO:0007616: long-term memory
GO:0043066: negative regulation of apoptotic process
GO:0008286: insulin receptor signaling pathway
GO:0042493: response to drug
GO:0009636: response to toxic substance
GO:0009408: response to heat
GO:0009611: response to wounding
GO:0009749: response to glucose stimulus
GO:0014732: skeletal muscle atrophy
GO:0014878: response to electrical stimulus involved in regulation of muscle adaptation
GO:0014911: positive regulation of smooth muscle cell migration
GO:0045727: positive regulation of translation
GO:0016477: cell migration
GO:0048015: phosphatidylinositol-mediated signaling
GO:0031929: TOR signaling cascade
GO:0032496: response to lipopolysaccharide
GO:0033574: response to testosterone stimulus
GO:0033762: response to glucagon stimulus
GO:0034612: response to tumor necrosis factor
GO:0043201: response to leucine
GO:0043491: protein kinase B signaling cascade
GO:0045471: response to ethanol
GO:0045931: positive regulation of mitotic cell cycle
GO:0045948: positive regulation of translational initiation
GO:0046324: regulation of glucose import
GO:0046627: negative regulation of insulin receptor signaling pathway
GO:0048633: positive regulation of skeletal muscle tissue growth
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0051384: response to glucocorticoid stimulus
GO:0071363: cellular response to growth factor stimulus
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005741: mitochondrial outer membrane
GO:0009986: cell surface
GO:0043005: neuron projection
GO:0030054: cell junction
GO:0045202: synapse
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0004672: protein kinase activity
GO:0004711: ribosomal protein S6 kinase activity
GO:0005524: ATP binding
GO:0042277: peptide binding
KEGG pathways 4012: ErbB signaling pathway
4150: mTOR signaling pathway
4350: TGF-beta signaling pathway
4666: Fc gamma R-mediated phagocytosis
4910: Insulin signaling pathway
5221: Acute myeloid leukemia

PubMed abstracts associated with RPS6KB1

PMID Title Tumor Value
19148492 Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. no no
19936974 mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis. yes yes
21246613 Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. no no
22993301 Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-?B and MAPK pathways. no no
23879172 FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. no no
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