Results for BGLAP

General Information

Gene ID 632
Gene Symbol BGLAP
Gene Name bone gamma-carboxyglutamate (gla) protein
Gene Type protein-coding
Cytoband 1q22
Ensembl ID ENSG00000242252
#miR regulators ---
Omim ID 112260
Gene ontology GO:0001501: skeletal system development
GO:0001649: osteoblast differentiation
GO:0002076: osteoblast development
GO:0007155: cell adhesion
GO:0009612: response to mechanical stimulus
GO:0007569: cell aging
GO:0042493: response to drug
GO:0009629: response to gravity
GO:0010043: response to zinc ion
GO:0014823: response to activity
GO:0030282: bone mineralization
GO:0030500: regulation of bone mineralization
GO:0032571: response to vitamin K
GO:0033280: response to vitamin D
GO:0033574: response to testosterone stimulus
GO:0033594: response to hydroxyisoflavone
GO:0042476: odontogenesis
GO:0043627: response to estrogen stimulus
GO:0045124: regulation of bone resorption
GO:0045471: response to ethanol
GO:0045670: regulation of osteoclast differentiation
GO:0051384: response to glucocorticoid stimulus
GO:0060348: bone development
GO:0071305: cellular response to vitamin D
GO:0071363: cellular response to growth factor stimulus
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0005791: rough endoplasmic reticulum
GO:0005794: Golgi apparatus
GO:0030425: dendrite
GO:0031988: membrane-bounded vesicle
GO:0043204: perikaryon
GO:0005509: calcium ion binding
GO:0005198: structural molecule activity
GO:0008147: structural constituent of bone
GO:0046848: hydroxyapatite binding
KEGG pathways ---

PubMed abstracts associated with BGLAP

PMID Title Tumor Value
1320449 Immunohistochemical study of bone GLA protein in primary bone tumors. yes yes
1459694 Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. no no
1657330 Hormonal regulation of vitamin D receptor levels and osteocalcin synthesis in human osteosarcoma cells. no no
1864588 Immunophenotypic heterogeneity in osteosarcomas. yes yes
7576109 Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. no no
7817811 Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. no no
8281940 Insulin-like growth factor-1 modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells. no no
8840973 Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. no no
8922947 Analysis of the presence of osteocalcin, S-100 protein, and proliferating cell nuclear antigen in cells of various types of osteosarcomas. yes yes
8968028 Influence of vitamin D and retinoids on the gammacarboxylation of osteocalcin in human osteosarcoma MG63 cells. no no
9167046 Histological and immunohistochemical diversities, and proliferative activity and grading in osteosarcomas. yes no
9322601 Osteocalcin and osteonectin immunoreactivity in the diagnosis of osteosarcoma. yes yes
9923924 Osteocalcin and osteonectin immunoreactivity in extraskeletal osteosarcoma: a study of 28 cases. yes yes
10491221 The transcription factor Sox9 is involved in BMP-2 signaling. no no
10569470 Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. yes no
11306692 The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. no no
11746520 Cellular and molecular properties associated with osteosarcoma cells. yes no
12237108 Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. no no
12393937 Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation. no no
14506946 Urinary excretion of pyridinium cross-links and serum osteocalcin levels in patients with primary high-grade osteosarcoma. yes yes
14682477 Effects of progesterone and 18-methyl levonorgestrel on osteoblastic cells. no no
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. no no
16259979 Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. no no
16533764 Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. no no
16956425 Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells. no no
17120184 Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. no no
17189270 alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity. no no
17254772 RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. no no
17458711 Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. no no
18838962 Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. no no
20627196 Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. no no
20664979 N-myc downstream-regulated gene 1/Cap43 expression promotes cell differentiation of human osteosarcoma cells. no no
20955951 Markers of bone remodeling in neoplastic and bone-related lesions. yes no
21084254 Clinical utility of biochemical bone turnover markers in children and adolescents with osteosarcoma. yes yes
22870593 Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas. yes yes
22527131 Tissue transglutaminase (TG2) activity regulates osteoblast differentiation and mineralization in the SAOS-2 cell line. no no
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