General Information
Gene ID | 632 |
---|---|
Gene Symbol | BGLAP |
Gene Name | bone gamma-carboxyglutamate (gla) protein |
Gene Type | protein-coding |
Cytoband | 1q22 |
Ensembl ID | ENSG00000242252 |
#miR regulators | --- |
Omim ID | 112260 |
Gene ontology |
GO:0001501: skeletal system development GO:0001649: osteoblast differentiation GO:0002076: osteoblast development GO:0007155: cell adhesion GO:0009612: response to mechanical stimulus GO:0007569: cell aging GO:0042493: response to drug GO:0009629: response to gravity GO:0010043: response to zinc ion GO:0014823: response to activity GO:0030282: bone mineralization GO:0030500: regulation of bone mineralization GO:0032571: response to vitamin K GO:0033280: response to vitamin D GO:0033574: response to testosterone stimulus GO:0033594: response to hydroxyisoflavone GO:0042476: odontogenesis GO:0043627: response to estrogen stimulus GO:0045124: regulation of bone resorption GO:0045471: response to ethanol GO:0045670: regulation of osteoclast differentiation GO:0051384: response to glucocorticoid stimulus GO:0060348: bone development GO:0071305: cellular response to vitamin D GO:0071363: cellular response to growth factor stimulus GO:0005576: extracellular region GO:0005615: extracellular space GO:0005791: rough endoplasmic reticulum GO:0005794: Golgi apparatus GO:0030425: dendrite GO:0031988: membrane-bounded vesicle GO:0043204: perikaryon GO:0005509: calcium ion binding GO:0005198: structural molecule activity GO:0008147: structural constituent of bone GO:0046848: hydroxyapatite binding |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
1320449 | Immunohistochemical study of bone GLA protein in primary bone tumors. | yes | yes |
1459694 | Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. | no | no |
1657330 | Hormonal regulation of vitamin D receptor levels and osteocalcin synthesis in human osteosarcoma cells. | no | no |
1864588 | Immunophenotypic heterogeneity in osteosarcomas. | yes | yes |
7576109 | Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. | no | no |
7817811 | Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. | no | no |
8281940 | Insulin-like growth factor-1 modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells. | no | no |
8840973 | Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. | no | no |
8922947 | Analysis of the presence of osteocalcin, S-100 protein, and proliferating cell nuclear antigen in cells of various types of osteosarcomas. | yes | yes |
8968028 | Influence of vitamin D and retinoids on the gammacarboxylation of osteocalcin in human osteosarcoma MG63 cells. | no | no |
9167046 | Histological and immunohistochemical diversities, and proliferative activity and grading in osteosarcomas. | yes | no |
9322601 | Osteocalcin and osteonectin immunoreactivity in the diagnosis of osteosarcoma. | yes | yes |
9923924 | Osteocalcin and osteonectin immunoreactivity in extraskeletal osteosarcoma: a study of 28 cases. | yes | yes |
10491221 | The transcription factor Sox9 is involved in BMP-2 signaling. | no | no |
10569470 | Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. | yes | no |
11306692 | The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. | no | no |
11746520 | Cellular and molecular properties associated with osteosarcoma cells. | yes | no |
12237108 | Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. | no | no |
12393937 | Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation. | no | no |
14506946 | Urinary excretion of pyridinium cross-links and serum osteocalcin levels in patients with primary high-grade osteosarcoma. | yes | yes |
14682477 | Effects of progesterone and 18-methyl levonorgestrel on osteoblastic cells. | no | no |
15670817 | Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. | no | no |
16259979 | Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. | no | no |
16533764 | Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. | no | no |
16956425 | Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells. | no | no |
17120184 | Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. | no | no |
17189270 | alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity. | no | no |
17254772 | RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. | no | no |
17458711 | Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. | no | no |
18838962 | Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. | no | no |
20627196 | Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. | no | no |
20664979 | N-myc downstream-regulated gene 1/Cap43 expression promotes cell differentiation of human osteosarcoma cells. | no | no |
20955951 | Markers of bone remodeling in neoplastic and bone-related lesions. | yes | no |
21084254 | Clinical utility of biochemical bone turnover markers in children and adolescents with osteosarcoma. | yes | yes |
22870593 | Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas. | yes | yes |
22527131 | Tissue transglutaminase (TG2) activity regulates osteoblast differentiation and mineralization in the SAOS-2 cell line. | no | no |
title | all | all |