Results for SHH

General Information

Gene ID 6469
Gene Symbol SHH
Gene Name sonic hedgehog
Gene Type protein-coding
Cytoband 7q36
Ensembl ID ENSG00000164690
#miR regulators ---
Omim ID 142945 147250 269160 600725 611638
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001569: patterning of blood vessels
GO:0001570: vasculogenesis
GO:0001656: metanephros development
GO:0001658: branching involved in ureteric bud morphogenesis
GO:0001708: cell fate specification
GO:0001755: neural crest cell migration
GO:0001947: heart looping
GO:0002052: positive regulation of neuroblast proliferation
GO:0002076: osteoblast development
GO:0002320: lymphoid progenitor cell differentiation
GO:0003140: determination of left/right asymmetry in lateral mesoderm
GO:0007596: blood coagulation
GO:0006915: apoptotic process
GO:0006508: proteolysis
GO:0006897: endocytosis
GO:0030010: establishment of cell polarity
GO:0007224: smoothened signaling pathway
GO:0007228: positive regulation of hh target transcription factor activity
GO:0007267: cell-cell signaling
GO:0009790: embryo development
GO:0009880: embryonic pattern specification
GO:0007389: pattern specification process
GO:0007398: ectoderm development
GO:0007405: neuroblast proliferation
GO:0007411: axon guidance
GO:0007417: central nervous system development
GO:0007418: ventral midline development
GO:0007442: hindgut morphogenesis
GO:0007507: heart development
GO:0008209: androgen metabolic process
GO:0008284: positive regulation of cell proliferation
GO:0009952: anterior/posterior pattern specification
GO:0009953: dorsal/ventral pattern formation
GO:0014003: oligodendrocyte development
GO:0014858: positive regulation of skeletal muscle cell proliferation
GO:0014902: myotube differentiation
GO:0042981: regulation of apoptotic process
GO:0016539: intein-mediated protein splicing
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0021513: spinal cord dorsal/ventral patterning
GO:0021522: spinal cord motor neuron differentiation
GO:0021794: thalamus development
GO:0021904: dorsal/ventral neural tube patterning
GO:0021938: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021978: telencephalon regionalization
GO:0030162: regulation of proteolysis
GO:0030177: positive regulation of Wnt receptor signaling pathway
GO:0030324: lung development
GO:0030326: embryonic limb morphogenesis
GO:0030336: negative regulation of cell migration
GO:0030539: male genitalia development
GO:0030850: prostate gland development
GO:0030878: thyroid gland development
GO:0030900: forebrain development
GO:0030901: midbrain development
GO:0030902: hindbrain development
GO:0031016: pancreas development
GO:0031069: hair follicle morphogenesis
GO:0032435: negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033077: T cell differentiation in thymus
GO:0033089: positive regulation of T cell differentiation in thymus
GO:0033092: positive regulation of immature T cell proliferation in thymus
GO:0034244: negative regulation of transcription elongation from RNA polymerase II promoter
GO:0034504: protein localization to nucleus
GO:0035115: embryonic forelimb morphogenesis
GO:0035116: embryonic hindlimb morphogenesis
GO:1900175: regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:0042127: regulation of cell proliferation
GO:0042130: negative regulation of T cell proliferation
GO:0042307: positive regulation of protein import into nucleus
GO:0042475: odontogenesis of dentin-containing tooth
GO:0042481: regulation of odontogenesis
GO:0042733: embryonic digit morphogenesis
GO:0043010: camera-type eye development
GO:0043369: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0045059: positive thymic T cell selection
GO:0045060: negative thymic T cell selection
GO:0045109: intermediate filament organization
GO:0045445: myoblast differentiation
GO:0045596: negative regulation of cell differentiation
GO:0045880: positive regulation of smoothened signaling pathway
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046638: positive regulation of alpha-beta T cell differentiation
GO:0046639: negative regulation of alpha-beta T cell differentiation
GO:0048468: cell development
GO:0048538: thymus development
GO:0048617: embryonic foregut morphogenesis
GO:0048643: positive regulation of skeletal muscle tissue development
GO:0048645: organ formation
GO:0048663: neuron fate commitment
GO:0048706: embryonic skeletal system development
GO:0048714: positive regulation of oligodendrocyte differentiation
GO:0048754: branching morphogenesis of an epithelial tube
GO:0048839: inner ear development
GO:0048859: formation of anatomical boundary
GO:0048864: stem cell development
GO:0051155: positive regulation of striated muscle cell differentiation
GO:0051781: positive regulation of cell division
GO:0060020: Bergmann glial cell differentiation
GO:0060021: palate development
GO:0060070: canonical Wnt receptor signaling pathway
GO:0060174: limb bud formation
GO:0060428: lung epithelium development
GO:0060439: trachea morphogenesis
GO:0060445: branching involved in salivary gland morphogenesis
GO:0060447: bud outgrowth involved in lung branching
GO:0060458: right lung development
GO:0060459: left lung development
GO:0060463: lung lobe morphogenesis
GO:0060484: lung-associated mesenchyme development
GO:0060516: primary prostatic bud elongation
GO:0060523: prostate epithelial cord elongation
GO:0060662: salivary gland cavitation
GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060685: regulation of prostatic bud formation
GO:0060738: epithelial-mesenchymal signaling involved in prostate gland development
GO:0060769: positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060782: regulation of mesenchymal cell proliferation involved in prostate gland development
GO:0060783: mesenchymal smoothened signaling pathway involved in prostate gland development
GO:0060840: artery development
GO:0060916: mesenchymal cell proliferation involved in lung development
GO:0061053: somite development
GO:0061189: positive regulation of sclerotome development
GO:0071285: cellular response to lithium ion
GO:0072001: renal system development
GO:0072136: metanephric mesenchymal cell proliferation involved in metanephros development
GO:0080125: multicellular structure septum development
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:0090370: negative regulation of cholesterol efflux
GO:1900180: regulation of protein localization to nucleus
GO:2000062: negative regulation of ureter smooth muscle cell differentiation
GO:2000063: positive regulation of ureter smooth muscle cell differentiation
GO:2000357: negative regulation of kidney smooth muscle cell differentiation
GO:2000358: positive regulation of kidney smooth muscle cell differentiation
GO:2000729: positive regulation of mesenchymal cell proliferation involved in ureter development
GO:0005886: plasma membrane
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0009986: cell surface
GO:0031012: extracellular matrix
GO:0045121: membrane raft
GO:0005515: protein binding
GO:0005509: calcium ion binding
GO:0001948: glycoprotein binding
GO:0008233: peptidase activity
GO:0004871: signal transducer activity
GO:0005113: patched binding
GO:0005539: glycosaminoglycan binding
GO:0008270: zinc ion binding
GO:0016015: morphogen activity
GO:0043237: laminin-1 binding
KEGG pathways 4340: Hedgehog signaling pathway
5200: Pathways in cancer
5217: Basal cell carcinoma

PubMed abstracts associated with SHH

PMID Title Tumor Value
20067614 Smoothened as a new therapeutic target for human osteosarcoma. yes no
title all all