General Information
Gene ID | 64750 |
---|---|
Gene Symbol | SMURF2 |
Gene Name | SMAD specific E3 ubiquitin protein ligase 2 |
Gene Type | protein-coding |
Cytoband | 17q22-q23 |
Ensembl ID | ENSG00000108854 ENSG00000262909 |
#miR regulators | 12 |
Omim ID | 605532 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0042787: protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0006351: transcription, DNA-dependent GO:0006367: transcription initiation from RNA polymerase II promoter GO:0006511: ubiquitin-dependent protein catabolic process GO:0007179: transforming growth factor beta receptor signaling pathway GO:0010467: gene expression GO:0045892: negative regulation of transcription, DNA-dependent GO:0017015: regulation of transforming growth factor beta receptor signaling pathway GO:0030509: BMP signaling pathway GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway GO:0030579: ubiquitin-dependent SMAD protein catabolic process GO:0005886: plasma membrane GO:0000151: ubiquitin ligase complex GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0045121: membrane raft GO:0005515: protein binding GO:0004842: ubiquitin-protein ligase activity GO:0005160: transforming growth factor beta receptor binding GO:0042802: identical protein binding GO:0046332: SMAD binding |
KEGG pathways |
4120: Ubiquitin mediated proteolysis 4144: Endocytosis 4350: TGF-beta signaling pathway |
PMID | Title | Tumor | Value |
---|---|---|---|
21945933 | RLIM interacts with Smurf2 and promotes TGF-β induced U2OS cell migration. | no | no |
title | all | all |