Results for BMP2

General Information

Gene ID 650
Gene Symbol BMP2
Gene Name bone morphogenetic protein 2
Gene Type protein-coding
Cytoband 20p12
Ensembl ID ENSG00000125845
#miR regulators 3
Omim ID 112261 112600 235200
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000187: activation of MAPK activity
GO:0001501: skeletal system development
GO:0006029: proteoglycan metabolic process
GO:0001649: osteoblast differentiation
GO:0001658: branching involved in ureteric bud morphogenesis
GO:0001666: response to hypoxia
GO:0001701: in utero embryonic development
GO:0001837: epithelial to mesenchymal transition
GO:0001934: positive regulation of protein phosphorylation
GO:0001938: positive regulation of endothelial cell proliferation
GO:0002062: chondrocyte differentiation
GO:0003130: BMP signaling pathway involved in heart induction
GO:0003181: atrioventricular valve morphogenesis
GO:0003203: endocardial cushion morphogenesis
GO:0003308: negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0006355: regulation of transcription, DNA-dependent
GO:0006468: protein phosphorylation
GO:0006954: inflammatory response
GO:0040007: growth
GO:0007219: Notch signaling pathway
GO:0007267: cell-cell signaling
GO:0009790: embryo development
GO:0009887: organ morphogenesis
GO:0007507: heart development
GO:0008285: negative regulation of cell proliferation
GO:0010628: positive regulation of gene expression
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0010862: positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010894: negative regulation of steroid biosynthetic process
GO:0010922: positive regulation of phosphatase activity
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0021537: telencephalon development
GO:0021978: telencephalon regionalization
GO:0030177: positive regulation of Wnt receptor signaling pathway
GO:0030198: extracellular matrix organization
GO:0030282: bone mineralization
GO:0030335: positive regulation of cell migration
GO:0030501: positive regulation of bone mineralization
GO:0030509: BMP signaling pathway
GO:0031648: protein destabilization
GO:0032348: negative regulation of aldosterone biosynthetic process
GO:0033690: positive regulation of osteoblast proliferation
GO:0035051: cardiocyte differentiation
GO:0035054: embryonic heart tube anterior/posterior pattern specification
GO:0035630: bone mineralization involved in bone maturation
GO:0042475: odontogenesis of dentin-containing tooth
GO:0042482: positive regulation of odontogenesis
GO:0042487: regulation of odontogenesis of dentin-containing tooth
GO:0043065: positive regulation of apoptotic process
GO:0043410: positive regulation of MAPK cascade
GO:0043569: negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045165: cell fate commitment
GO:0045600: positive regulation of fat cell differentiation
GO:0045666: positive regulation of neuron differentiation
GO:0045669: positive regulation of osteoblast differentiation
GO:0045778: positive regulation of ossification
GO:0045786: negative regulation of cell cycle
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048711: positive regulation of astrocyte differentiation
GO:0048762: mesenchymal cell differentiation
GO:0048839: inner ear development
GO:0051042: negative regulation of calcium-independent cell-cell adhesion
GO:0055007: cardiac muscle cell differentiation
GO:0055008: cardiac muscle tissue morphogenesis
GO:0060039: pericardium development
GO:0060128: corticotropin hormone secreting cell differentiation
GO:0060129: thyroid-stimulating hormone-secreting cell differentiation
GO:0060317: cardiac epithelial to mesenchymal transition
GO:0060389: pathway-restricted SMAD protein phosphorylation
GO:0060395: SMAD protein signal transduction
GO:0060485: mesenchyme development
GO:0060804: positive regulation of Wnt receptor signaling pathway by BMP signaling pathway
GO:0061036: positive regulation of cartilage development
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0071407: cellular response to organic cyclic compound
GO:0071773: cellular response to BMP stimulus
GO:0072138: mesenchymal cell proliferation involved in ureteric bud development
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:1900745: positive regulation of p38MAPK cascade
GO:1901522: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:2000065: negative regulation of cortisol biosynthetic process
GO:2000726: negative regulation of cardiac muscle cell differentiation
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0009986: cell surface
GO:0005515: protein binding
GO:0005102: receptor binding
GO:0004745: retinol dehydrogenase activity
GO:0005125: cytokine activity
GO:0008083: growth factor activity
GO:0019211: phosphatase activator activity
GO:0046332: SMAD binding
GO:0046982: protein heterodimerization activity
GO:0070700: BMP receptor binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4340: Hedgehog signaling pathway
4350: TGF-beta signaling pathway
5200: Pathways in cancer
5217: Basal cell carcinoma

PubMed abstracts associated with BMP2

PMID Title Tumor Value
7506120 Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody. yes no
7641470 The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. no no
8039112 Immunohistochemical detection of bone morphogenetic proteins in bone and soft-tissue sarcomas. yes no
8717537 Bone morphogenetic protein-2 but not bone morphogenetic protein-4 and -6 stimulates chemotactic migration of human osteoblasts, human marrow osteoblasts, and U2-OS cells. no no
9069169 Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells. no no
10491221 The transcription factor Sox9 is involved in BMP-2 signaling. no no
10627702 Expression of bone morphogenetic proteins and receptors in sarcomas. yes yes
10814523 Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. no no
10846544 Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells. no no
11986346 The expression of bone morphogenetic proteins in osteosarcoma and its relevance as a prognostic parameter. yes no
15174116 Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. no no
16259979 Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. no no
16470222 RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. no no
19142873 De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeleton. no no
20627196 Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. no no
21178508 BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. no no
21951664 RUNX2 expression in developing human bones and various bone tumors. yes no
22527131 Tissue transglutaminase (TG2) activity regulates osteoblast differentiation and mineralization in the SAOS-2 cell line. no no
23262982 Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. no no
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