General Information
| Gene ID | 6502 |
|---|---|
| Gene Symbol | SKP2 |
| Gene Name | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| Gene Type | protein-coding |
| Cytoband | 5p13 |
| Ensembl ID | ENSG00000145604 |
| #miR regulators | 1 |
| Omim ID | 601436 |
| Gene ontology |
GO:0000082: G1/S transition of mitotic cell cycle GO:0000086: G2/M transition of mitotic cell cycle GO:0000209: protein polyubiquitination GO:0000278: mitotic cell cycle GO:0051726: regulation of cell cycle GO:0008283: cell proliferation GO:0031145: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0033148: positive regulation of intracellular estrogen receptor signaling pathway GO:0048661: positive regulation of smooth muscle cell proliferation GO:0071460: cellular response to cell-matrix adhesion GO:0005829: cytosol GO:0005654: nucleoplasm GO:0019005: SCF ubiquitin ligase complex GO:0005515: protein binding GO:0004842: ubiquitin-protein ligase activity GO:0042802: identical protein binding |
| KEGG pathways |
4110: Cell cycle 4120: Ubiquitin mediated proteolysis 5200: Pathways in cancer 5222: Small cell lung cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 19455146 | Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. | no | no |
| 20067614 | Smoothened as a new therapeutic target for human osteosarcoma. | yes | no |
| 21506130 | Role of GLI2 in the growth of human osteosarcoma. | yes | yes |
| title | all | all |