General Information
Gene ID | 652 |
---|---|
Gene Symbol | BMP4 |
Gene Name | bone morphogenetic protein 4 |
Gene Type | protein-coding |
Cytoband | 14q22-q23 |
Ensembl ID | ENSG00000125378 |
#miR regulators | 1 |
Omim ID | 112262 600625 607932 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0000186: activation of MAPKK activity GO:0001649: osteoblast differentiation GO:0001657: ureteric bud development GO:0001658: branching involved in ureteric bud morphogenesis GO:0001822: kidney development GO:0001823: mesonephros development GO:0001843: neural tube closure GO:0001934: positive regulation of protein phosphorylation GO:0001938: positive regulation of endothelial cell proliferation GO:0001958: endochondral ossification GO:0002043: blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002062: chondrocyte differentiation GO:0002244: hematopoietic progenitor cell differentiation GO:0002320: lymphoid progenitor cell differentiation GO:0003014: renal system process GO:0003130: BMP signaling pathway involved in heart induction GO:0003139: secondary heart field specification GO:0003197: endocardial cushion development GO:0003279: cardiac septum development GO:0003323: type B pancreatic cell development GO:0003337: mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0007182: common-partner SMAD protein phosphorylation GO:0007224: smoothened signaling pathway GO:0007281: germ cell development GO:0007500: mesodermal cell fate determination GO:0043066: negative regulation of apoptotic process GO:0008285: negative regulation of cell proliferation GO:0009791: post-embryonic development GO:0009948: anterior/posterior axis specification GO:0010159: specification of organ position GO:0010595: positive regulation of endothelial cell migration GO:0010862: positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010942: positive regulation of cell death GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0021537: telencephalon development GO:0021904: dorsal/ventral neural tube patterning GO:0021978: telencephalon regionalization GO:0021983: pituitary gland development GO:0030198: extracellular matrix organization GO:0030218: erythrocyte differentiation GO:0030224: monocyte differentiation GO:0030225: macrophage differentiation GO:0030501: positive regulation of bone mineralization GO:0030509: BMP signaling pathway GO:0030513: positive regulation of BMP signaling pathway GO:0032331: negative regulation of chondrocyte differentiation GO:0032967: positive regulation of collagen biosynthetic process GO:0033085: negative regulation of T cell differentiation in thymus GO:0033088: negative regulation of immature T cell proliferation in thymus GO:0034504: protein localization to nucleus GO:0035116: embryonic hindlimb morphogenesis GO:0035990: tendon cell differentiation GO:0035993: deltoid tuberosity development GO:0042326: negative regulation of phosphorylation GO:0042475: odontogenesis of dentin-containing tooth GO:0042476: odontogenesis GO:0042487: regulation of odontogenesis of dentin-containing tooth GO:0042733: embryonic digit morphogenesis GO:0043065: positive regulation of apoptotic process GO:0043401: steroid hormone mediated signaling pathway GO:0043407: negative regulation of MAP kinase activity GO:0045603: positive regulation of endothelial cell differentiation GO:0045662: negative regulation of myoblast differentiation GO:0045666: positive regulation of neuron differentiation GO:0045669: positive regulation of osteoblast differentiation GO:0045778: positive regulation of ossification GO:0045786: negative regulation of cell cycle GO:0045839: negative regulation of mitosis GO:0045843: negative regulation of striated muscle tissue development GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048286: lung alveolus development GO:0048392: intermediate mesodermal cell differentiation GO:0048661: positive regulation of smooth muscle cell proliferation GO:0048663: neuron fate commitment GO:0048701: embryonic cranial skeleton morphogenesis GO:0048745: smooth muscle tissue development GO:0048754: branching morphogenesis of an epithelial tube GO:0050679: positive regulation of epithelial cell proliferation GO:0050680: negative regulation of epithelial cell proliferation GO:0050918: positive chemotaxis GO:0051150: regulation of smooth muscle cell differentiation GO:0055007: cardiac muscle cell differentiation GO:0055020: positive regulation of cardiac muscle fiber development GO:0060113: inner ear receptor cell differentiation GO:0060197: cloacal septation GO:0060235: lens induction in camera-type eye GO:0060272: embryonic skeletal joint morphogenesis GO:0060363: cranial suture morphogenesis GO:0060391: positive regulation of SMAD protein import into nucleus GO:0060393: regulation of pathway-restricted SMAD protein phosphorylation GO:0060395: SMAD protein signal transduction GO:0060425: lung morphogenesis GO:0060433: bronchus development GO:0060438: trachea development GO:0060440: trachea formation GO:0060441: epithelial tube branching involved in lung morphogenesis GO:0060442: branching involved in prostate gland morphogenesis GO:0060449: bud elongation involved in lung branching GO:0060502: epithelial cell proliferation involved in lung morphogenesis GO:0060503: bud dilation involved in lung branching GO:0060548: negative regulation of cell death GO:0060592: mammary gland formation GO:0060684: epithelial-mesenchymal cell signaling GO:0060686: negative regulation of prostatic bud formation GO:0060687: regulation of branching involved in prostate gland morphogenesis GO:0061036: positive regulation of cartilage development GO:0061047: positive regulation of branching involved in lung morphogenesis GO:0061149: BMP signaling pathway involved in ureter morphogenesis GO:0061151: BMP signaling pathway involved in renal system segmentation GO:0061155: pulmonary artery endothelial tube morphogenesis GO:0070244: negative regulation of thymocyte apoptotic process GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0071363: cellular response to growth factor stimulus GO:0071893: BMP signaling pathway involved in nephric duct formation GO:0072001: renal system development GO:0072015: glomerular visceral epithelial cell development GO:0072097: negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway GO:0072101: specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway GO:0072104: glomerular capillary formation GO:0072125: negative regulation of glomerular mesangial cell proliferation GO:0072138: mesenchymal cell proliferation involved in ureteric bud development GO:0072161: mesenchymal cell differentiation involved in kidney development GO:0072192: ureter epithelial cell differentiation GO:0072193: ureter smooth muscle cell differentiation GO:0072198: mesenchymal cell proliferation involved in ureter development GO:0072200: negative regulation of mesenchymal cell proliferation involved in ureter development GO:0072205: metanephric collecting duct development GO:0090184: positive regulation of kidney development GO:0090191: negative regulation of branching involved in ureteric bud morphogenesis GO:0090194: negative regulation of glomerulus development GO:2000005: negative regulation of metanephric S-shaped body morphogenesis GO:2000007: negative regulation of metanephric comma-shaped body morphogenesis GO:2000105: positive regulation of DNA-dependent DNA replication GO:2000137: negative regulation of cell proliferation involved in heart morphogenesis GO:0005576: extracellular region GO:0005578: proteinaceous extracellular matrix GO:0005615: extracellular space GO:0005515: protein binding GO:0005125: cytokine activity GO:0008083: growth factor activity GO:0008201: heparin binding GO:0042056: chemoattractant activity GO:0070700: BMP receptor binding |
KEGG pathways |
4340: Hedgehog signaling pathway 4350: TGF-beta signaling pathway 5200: Pathways in cancer 5217: Basal cell carcinoma |
PMID | Title | Tumor | Value |
---|---|---|---|
7506120 | Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody. | yes | no |
7641470 | The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. | no | no |
8039112 | Immunohistochemical detection of bone morphogenetic proteins in bone and soft-tissue sarcomas. | yes | no |
9069169 | Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells. | no | no |
10627702 | Expression of bone morphogenetic proteins and receptors in sarcomas. | yes | yes |
10846544 | Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells. | no | no |
11986346 | The expression of bone morphogenetic proteins in osteosarcoma and its relevance as a prognostic parameter. | yes | no |
12237108 | Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. | no | no |
15174116 | Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. | no | no |
title | all | all |