Results for BMP4

General Information

Gene ID 652
Gene Symbol BMP4
Gene Name bone morphogenetic protein 4
Gene Type protein-coding
Cytoband 14q22-q23
Ensembl ID ENSG00000125378
#miR regulators 1
Omim ID 112262 600625 607932
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000186: activation of MAPKK activity
GO:0001649: osteoblast differentiation
GO:0001657: ureteric bud development
GO:0001658: branching involved in ureteric bud morphogenesis
GO:0001822: kidney development
GO:0001823: mesonephros development
GO:0001843: neural tube closure
GO:0001934: positive regulation of protein phosphorylation
GO:0001938: positive regulation of endothelial cell proliferation
GO:0001958: endochondral ossification
GO:0002043: blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062: chondrocyte differentiation
GO:0002244: hematopoietic progenitor cell differentiation
GO:0002320: lymphoid progenitor cell differentiation
GO:0003014: renal system process
GO:0003130: BMP signaling pathway involved in heart induction
GO:0003139: secondary heart field specification
GO:0003197: endocardial cushion development
GO:0003279: cardiac septum development
GO:0003323: type B pancreatic cell development
GO:0003337: mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007182: common-partner SMAD protein phosphorylation
GO:0007224: smoothened signaling pathway
GO:0007281: germ cell development
GO:0007500: mesodermal cell fate determination
GO:0043066: negative regulation of apoptotic process
GO:0008285: negative regulation of cell proliferation
GO:0009791: post-embryonic development
GO:0009948: anterior/posterior axis specification
GO:0010159: specification of organ position
GO:0010595: positive regulation of endothelial cell migration
GO:0010862: positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942: positive regulation of cell death
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0021537: telencephalon development
GO:0021904: dorsal/ventral neural tube patterning
GO:0021978: telencephalon regionalization
GO:0021983: pituitary gland development
GO:0030198: extracellular matrix organization
GO:0030218: erythrocyte differentiation
GO:0030224: monocyte differentiation
GO:0030225: macrophage differentiation
GO:0030501: positive regulation of bone mineralization
GO:0030509: BMP signaling pathway
GO:0030513: positive regulation of BMP signaling pathway
GO:0032331: negative regulation of chondrocyte differentiation
GO:0032967: positive regulation of collagen biosynthetic process
GO:0033085: negative regulation of T cell differentiation in thymus
GO:0033088: negative regulation of immature T cell proliferation in thymus
GO:0034504: protein localization to nucleus
GO:0035116: embryonic hindlimb morphogenesis
GO:0035990: tendon cell differentiation
GO:0035993: deltoid tuberosity development
GO:0042326: negative regulation of phosphorylation
GO:0042475: odontogenesis of dentin-containing tooth
GO:0042476: odontogenesis
GO:0042487: regulation of odontogenesis of dentin-containing tooth
GO:0042733: embryonic digit morphogenesis
GO:0043065: positive regulation of apoptotic process
GO:0043401: steroid hormone mediated signaling pathway
GO:0043407: negative regulation of MAP kinase activity
GO:0045603: positive regulation of endothelial cell differentiation
GO:0045662: negative regulation of myoblast differentiation
GO:0045666: positive regulation of neuron differentiation
GO:0045669: positive regulation of osteoblast differentiation
GO:0045778: positive regulation of ossification
GO:0045786: negative regulation of cell cycle
GO:0045839: negative regulation of mitosis
GO:0045843: negative regulation of striated muscle tissue development
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048286: lung alveolus development
GO:0048392: intermediate mesodermal cell differentiation
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0048663: neuron fate commitment
GO:0048701: embryonic cranial skeleton morphogenesis
GO:0048745: smooth muscle tissue development
GO:0048754: branching morphogenesis of an epithelial tube
GO:0050679: positive regulation of epithelial cell proliferation
GO:0050680: negative regulation of epithelial cell proliferation
GO:0050918: positive chemotaxis
GO:0051150: regulation of smooth muscle cell differentiation
GO:0055007: cardiac muscle cell differentiation
GO:0055020: positive regulation of cardiac muscle fiber development
GO:0060113: inner ear receptor cell differentiation
GO:0060197: cloacal septation
GO:0060235: lens induction in camera-type eye
GO:0060272: embryonic skeletal joint morphogenesis
GO:0060363: cranial suture morphogenesis
GO:0060391: positive regulation of SMAD protein import into nucleus
GO:0060393: regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395: SMAD protein signal transduction
GO:0060425: lung morphogenesis
GO:0060433: bronchus development
GO:0060438: trachea development
GO:0060440: trachea formation
GO:0060441: epithelial tube branching involved in lung morphogenesis
GO:0060442: branching involved in prostate gland morphogenesis
GO:0060449: bud elongation involved in lung branching
GO:0060502: epithelial cell proliferation involved in lung morphogenesis
GO:0060503: bud dilation involved in lung branching
GO:0060548: negative regulation of cell death
GO:0060592: mammary gland formation
GO:0060684: epithelial-mesenchymal cell signaling
GO:0060686: negative regulation of prostatic bud formation
GO:0060687: regulation of branching involved in prostate gland morphogenesis
GO:0061036: positive regulation of cartilage development
GO:0061047: positive regulation of branching involved in lung morphogenesis
GO:0061149: BMP signaling pathway involved in ureter morphogenesis
GO:0061151: BMP signaling pathway involved in renal system segmentation
GO:0061155: pulmonary artery endothelial tube morphogenesis
GO:0070244: negative regulation of thymocyte apoptotic process
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0071363: cellular response to growth factor stimulus
GO:0071893: BMP signaling pathway involved in nephric duct formation
GO:0072001: renal system development
GO:0072015: glomerular visceral epithelial cell development
GO:0072097: negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101: specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104: glomerular capillary formation
GO:0072125: negative regulation of glomerular mesangial cell proliferation
GO:0072138: mesenchymal cell proliferation involved in ureteric bud development
GO:0072161: mesenchymal cell differentiation involved in kidney development
GO:0072192: ureter epithelial cell differentiation
GO:0072193: ureter smooth muscle cell differentiation
GO:0072198: mesenchymal cell proliferation involved in ureter development
GO:0072200: negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205: metanephric collecting duct development
GO:0090184: positive regulation of kidney development
GO:0090191: negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194: negative regulation of glomerulus development
GO:2000005: negative regulation of metanephric S-shaped body morphogenesis
GO:2000007: negative regulation of metanephric comma-shaped body morphogenesis
GO:2000105: positive regulation of DNA-dependent DNA replication
GO:2000137: negative regulation of cell proliferation involved in heart morphogenesis
GO:0005576: extracellular region
GO:0005578: proteinaceous extracellular matrix
GO:0005615: extracellular space
GO:0005515: protein binding
GO:0005125: cytokine activity
GO:0008083: growth factor activity
GO:0008201: heparin binding
GO:0042056: chemoattractant activity
GO:0070700: BMP receptor binding
KEGG pathways 4340: Hedgehog signaling pathway
4350: TGF-beta signaling pathway
5200: Pathways in cancer
5217: Basal cell carcinoma

PubMed abstracts associated with BMP4

PMID Title Tumor Value
7506120 Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody. yes no
7641470 The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. no no
8039112 Immunohistochemical detection of bone morphogenetic proteins in bone and soft-tissue sarcomas. yes no
9069169 Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells. no no
10627702 Expression of bone morphogenetic proteins and receptors in sarcomas. yes yes
10846544 Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells. no no
11986346 The expression of bone morphogenetic proteins in osteosarcoma and its relevance as a prognostic parameter. yes no
12237108 Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. no no
15174116 Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. no no
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