General Information
Gene ID | 6573 |
---|---|
Gene Symbol | SLC19A1 |
Gene Name | solute carrier family 19 (folate transporter), member 1 |
Gene Type | protein-coding |
Cytoband | 21q22.3 |
Ensembl ID | ENSG00000173638 |
#miR regulators | 4 |
Omim ID | 600424 |
Gene ontology |
GO:0006766: vitamin metabolic process GO:0006767: water-soluble vitamin metabolic process GO:0015884: folic acid transport GO:0044281: small molecule metabolic process GO:0046655: folic acid metabolic process GO:0051958: methotrexate transport GO:0005886: plasma membrane GO:0016020: membrane GO:0005887: integral to plasma membrane GO:0005542: folic acid binding GO:0008517: folic acid transporter activity GO:0008518: reduced folate carrier activity GO:0015350: methotrexate transporter activity |
KEGG pathways |
4977: Vitamin digestion and absorption |
PMID | Title | Tumor | Value |
---|---|---|---|
12813132 | mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. | yes | yes |
14584080 | Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity. | yes | yes |
14679136 | Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. | yes | yes |
17473184 | The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. | yes | no |
title | all | all |