Results for SLC19A1

General Information

Gene ID 6573
Gene Symbol SLC19A1
Gene Name solute carrier family 19 (folate transporter), member 1
Gene Type protein-coding
Cytoband 21q22.3
Ensembl ID ENSG00000173638
#miR regulators 4
Omim ID 600424
Gene ontology GO:0006766: vitamin metabolic process
GO:0006767: water-soluble vitamin metabolic process
GO:0015884: folic acid transport
GO:0044281: small molecule metabolic process
GO:0046655: folic acid metabolic process
GO:0051958: methotrexate transport
GO:0005886: plasma membrane
GO:0016020: membrane
GO:0005887: integral to plasma membrane
GO:0005542: folic acid binding
GO:0008517: folic acid transporter activity
GO:0008518: reduced folate carrier activity
GO:0015350: methotrexate transporter activity
KEGG pathways 4977: Vitamin digestion and absorption

PubMed abstracts associated with SLC19A1

PMID Title Tumor Value
12813132 mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. yes yes
14584080 Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity. yes yes
14679136 Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. yes yes
17473184 The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. yes no
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