Results for SNAI2

General Information

Gene ID 6591
Gene Symbol SNAI2
Gene Name snail homolog 2 (Drosophila)
Gene Type protein-coding
Cytoband 8q11
Ensembl ID ENSG00000019549
#miR regulators 3
Omim ID 172800 602150 608890
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001649: osteoblast differentiation
GO:0001837: epithelial to mesenchymal transition
GO:0003198: epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003273: cell migration involved in endocardial cushion formation
GO:0006933: negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007219: Notch signaling pathway
GO:0009790: embryo development
GO:0007605: sensory perception of sound
GO:0010839: negative regulation of keratinocyte proliferation
GO:0010957: negative regulation of vitamin D biosynthetic process
GO:0014032: neural crest cell development
GO:0030335: positive regulation of cell migration
GO:0032331: negative regulation of chondrocyte differentiation
GO:0032642: regulation of chemokine production
GO:0033629: negative regulation of cell adhesion mediated by integrin
GO:0035066: positive regulation of histone acetylation
GO:0035414: negative regulation of catenin import into nucleus
GO:0035921: desmosome disassembly
GO:0043473: pigmentation
GO:0043518: negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044344: cellular response to fibroblast growth factor stimulus
GO:0045600: positive regulation of fat cell differentiation
GO:0045667: regulation of osteoblast differentiation
GO:0050872: white fat cell differentiation
GO:0060021: palate development
GO:0060070: canonical Wnt receptor signaling pathway
GO:0060429: epithelium development
GO:0060536: cartilage morphogenesis
GO:0070563: negative regulation of vitamin D receptor signaling pathway
GO:0071364: cellular response to epidermal growth factor stimulus
GO:0071479: cellular response to ionizing radiation
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:1900387: negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
GO:1902230: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000647: negative regulation of stem cell proliferation
GO:2000810: regulation of tight junction assembly
GO:2000811: negative regulation of anoikis
GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0000790: nuclear chromatin
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0001078: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003682: chromatin binding
GO:0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0046872: metal ion binding
GO:0043565: sequence-specific DNA binding
KEGG pathways 4520: Adherens junction

PubMed abstracts associated with SNAI2

PMID Title Tumor Value
17318900 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. no no
21207222 Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy. yes yes
23352643 Snail2 promotes osteosarcoma cell motility through remodelling of the actin cytoskeleton and regulates tumor development. no no
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