Results for SMO

General Information

Gene ID 6608
Gene Symbol SMO
Gene Name smoothened, frizzled family receptor
Gene Type protein-coding
Cytoband 7q32.3
Ensembl ID ENSG00000128602
#miR regulators 4
Omim ID 601500
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001570: vasculogenesis
GO:0001649: osteoblast differentiation
GO:0001701: in utero embryonic development
GO:0001708: cell fate specification
GO:0001755: neural crest cell migration
GO:0001947: heart looping
GO:0002052: positive regulation of neuroblast proliferation
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0003007: heart morphogenesis
GO:0003140: determination of left/right asymmetry in lateral mesoderm
GO:0003323: type B pancreatic cell development
GO:0007224: smoothened signaling pathway
GO:0007228: positive regulation of hh target transcription factor activity
GO:0007283: spermatogenesis
GO:0007368: determination of left/right symmetry
GO:0007371: ventral midline determination
GO:0007494: midgut development
GO:0043066: negative regulation of apoptotic process
GO:0008406: gonad development
GO:0010002: cardioblast differentiation
GO:0010628: positive regulation of gene expression
GO:0010629: negative regulation of gene expression
GO:0050821: protein stabilization
GO:0021508: floor plate formation
GO:0021561: facial nerve development
GO:0021696: cerebellar cortex morphogenesis
GO:0021794: thalamus development
GO:0021904: dorsal/ventral neural tube patterning
GO:0021910: smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953: central nervous system neuron differentiation
GO:0021984: adenohypophysis development
GO:0030857: negative regulation of epithelial cell differentiation
GO:0031017: exocrine pancreas development
GO:0031069: hair follicle morphogenesis
GO:0031076: embryonic camera-type eye development
GO:0031102: neuron projection regeneration
GO:0032474: otolith morphogenesis
GO:0034504: protein localization to nucleus
GO:0035264: multicellular organism growth
GO:0042307: positive regulation of protein import into nucleus
GO:0042475: odontogenesis of dentin-containing tooth
GO:0042693: muscle cell fate commitment
GO:0043392: negative regulation of DNA binding
GO:0045880: positive regulation of smoothened signaling pathway
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048557: embryonic digestive tract morphogenesis
GO:0048663: neuron fate commitment
GO:0048702: embryonic neurocranium morphogenesis
GO:0048703: embryonic viscerocranium morphogenesis
GO:0048752: semicircular canal morphogenesis
GO:0048846: axon extension involved in axon guidance
GO:0048853: forebrain morphogenesis
GO:0050679: positive regulation of epithelial cell proliferation
GO:0051799: negative regulation of hair follicle development
GO:0060070: canonical Wnt receptor signaling pathway
GO:0060248: detection of cell density by contact stimulus involved in contact inhibition
GO:0060644: mammary gland epithelial cell differentiation
GO:0060684: epithelial-mesenchymal cell signaling
GO:0060830: ciliary receptor clustering involved in smoothened signaling pathway
GO:0061053: somite development
GO:0061113: pancreas morphogenesis
GO:0071397: cellular response to cholesterol
GO:0072001: renal system development
GO:0072285: mesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0090190: positive regulation of branching involved in ureteric bud morphogenesis
GO:2000036: regulation of stem cell maintenance
GO:2000826: regulation of heart morphogenesis
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005737: cytoplasm
GO:0043231: intracellular membrane-bounded organelle
GO:0005794: Golgi apparatus
GO:0005901: caveola
GO:0005929: cilium
GO:0043025: neuronal cell body
GO:0060170: cilium membrane
GO:0072372: primary cilium
GO:0005515: protein binding
GO:0042813: Wnt-activated receptor activity
GO:0004930: G-protein coupled receptor activity
GO:0005113: patched binding
GO:0005119: smoothened binding
GO:0008144: drug binding
GO:0017147: Wnt-protein binding
GO:0030165: PDZ domain binding
KEGG pathways 4340: Hedgehog signaling pathway
5200: Pathways in cancer
5217: Basal cell carcinoma

PubMed abstracts associated with SMO

PMID Title Tumor Value
20067614 Smoothened as a new therapeutic target for human osteosarcoma. yes no
title all all