Results for SNCA

General Information

Gene ID 6622
Gene Symbol SNCA
Gene Name synuclein, alpha (non A4 component of amyloid precursor)
Gene Type protein-coding
Cytoband 4q21
Ensembl ID ENSG00000145335
#miR regulators 16
Omim ID 127750 163890 168601 605543
Gene ontology GO:0001774: microglial cell activation
GO:0001921: positive regulation of receptor recycling
GO:0001933: negative regulation of protein phosphorylation
GO:0001956: positive regulation of neurotransmitter secretion
GO:0055114: oxidation-reduction process
GO:0006631: fatty acid metabolic process
GO:0006638: neutral lipid metabolic process
GO:0006644: phospholipid metabolic process
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006: mitochondrial membrane organization
GO:0007568: aging
GO:0050812: regulation of acyl-CoA biosynthetic process
GO:0043066: negative regulation of apoptotic process
GO:0048148: behavioral response to cocaine
GO:0008344: adult locomotory behavior
GO:0042493: response to drug
GO:0010040: response to iron(II) ion
GO:0010517: regulation of phospholipase activity
GO:0010642: negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048: regulation of glutamate secretion
GO:0014059: regulation of dopamine secretion
GO:0031115: negative regulation of microtubule polymerization
GO:0031623: receptor internalization
GO:0031648: protein destabilization
GO:0032026: response to magnesium ion
GO:0032410: negative regulation of transporter activity
GO:0032496: response to lipopolysaccharide
GO:0032769: negative regulation of monooxygenase activity
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0034341: response to interferon-gamma
GO:0034599: cellular response to oxidative stress
GO:0035067: negative regulation of histone acetylation
GO:0040012: regulation of locomotion
GO:0042416: dopamine biosynthetic process
GO:0042775: mitochondrial ATP synthesis coupled electron transport
GO:0043030: regulation of macrophage activation
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043206: extracellular fibril organization
GO:0043524: negative regulation of neuron apoptotic process
GO:0044344: cellular response to fibroblast growth factor stimulus
GO:0045807: positive regulation of endocytosis
GO:0045920: negative regulation of exocytosis
GO:0045963: negative regulation of dopamine metabolic process
GO:0048169: regulation of long-term neuronal synaptic plasticity
GO:0048488: synaptic vesicle endocytosis
GO:0050808: synapse organization
GO:0051281: positive regulation of release of sequestered calcium ion into cytosol
GO:0051583: dopamine uptake involved in synaptic transmission
GO:0051585: negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612: negative regulation of serotonin uptake
GO:0051622: negative regulation of norepinephrine uptake
GO:0060079: regulation of excitatory postsynaptic membrane potential
GO:0060291: long-term synaptic potentiation
GO:0060732: positive regulation of inositol phosphate biosynthetic process
GO:0070495: negative regulation of thrombin receptor signaling pathway
GO:0070555: response to interleukin-1
GO:0071280: cellular response to copper ion
GO:0071872: cellular response to epinephrine stimulus
GO:0071902: positive regulation of protein serine/threonine kinase activity
GO:0005886: plasma membrane
GO:0005739: mitochondrion
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0005840: ribosome
GO:0005634: nucleus
GO:0005640: nuclear outer membrane
GO:0005737: cytoplasm
GO:0005791: rough endoplasmic reticulum
GO:0005794: Golgi apparatus
GO:0005938: cell cortex
GO:0008021: synaptic vesicle
GO:0015629: actin cytoskeleton
GO:0016234: inclusion body
GO:0030054: cell junction
GO:0030424: axon
GO:0030426: growth cone
GO:0031092: platelet alpha granule membrane
GO:0043195: terminal bouton
GO:0043205: fibril
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0000287: magnesium ion binding
GO:0005509: calcium ion binding
GO:0042393: histone binding
GO:0005507: copper ion binding
GO:0005543: phospholipid binding
GO:0016491: oxidoreductase activity
GO:0008017: microtubule binding
GO:0008198: ferrous iron binding
GO:0008270: zinc ion binding
GO:0042802: identical protein binding
GO:0019894: kinesin binding
GO:0019904: protein domain specific binding
GO:0030544: Hsp70 protein binding
GO:0043014: alpha-tubulin binding
GO:0043027: cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043274: phospholipase binding
GO:0045502: dynein binding
GO:0047485: protein N-terminus binding
GO:0048156: tau protein binding
GO:0048487: beta-tubulin binding
GO:0051219: phosphoprotein binding
KEGG pathways 5010: Alzheimer's disease
5012: Parkinson's disease

PubMed abstracts associated with SNCA

PMID Title Tumor Value
17189270 alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity. no no
title all all