Results for SOX2

General Information

Gene ID 6657
Gene Symbol SOX2
Gene Name SRY (sex determining region Y)-box 2
Gene Type protein-coding
Cytoband 3q26.3-q27
Ensembl ID ENSG00000181449
#miR regulators 6
Omim ID 184429 206900
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001649: osteoblast differentiation
GO:0001654: eye development
GO:0001714: endodermal cell fate specification
GO:0002052: positive regulation of neuroblast proliferation
GO:0006325: chromatin organization
GO:0006355: regulation of transcription, DNA-dependent
GO:0007050: cell cycle arrest
GO:0009611: response to wounding
GO:0010468: regulation of gene expression
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0021781: glial cell fate commitment
GO:0021879: forebrain neuron differentiation
GO:0021983: pituitary gland development
GO:0021984: adenohypophysis development
GO:0021987: cerebral cortex development
GO:0030539: male genitalia development
GO:0030858: positive regulation of epithelial cell differentiation
GO:0030900: forebrain development
GO:0030910: olfactory placode formation
GO:0032526: response to retinoic acid
GO:0035019: somatic stem cell maintenance
GO:0042472: inner ear morphogenesis
GO:0043281: regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410: positive regulation of MAPK cascade
GO:0043586: tongue development
GO:0045665: negative regulation of neuron differentiation
GO:0045666: positive regulation of neuron differentiation
GO:0045668: negative regulation of osteoblast differentiation
GO:0045747: positive regulation of Notch signaling pathway
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046148: pigment biosynthetic process
GO:0048286: lung alveolus development
GO:0048663: neuron fate commitment
GO:0048839: inner ear development
GO:0048852: diencephalon morphogenesis
GO:0050680: negative regulation of epithelial cell proliferation
GO:0050910: detection of mechanical stimulus involved in sensory perception of sound
GO:0050973: detection of mechanical stimulus involved in equilibrioception
GO:0070848: response to growth factor stimulus
GO:0060042: retina morphogenesis in camera-type eye
GO:0060235: lens induction in camera-type eye
GO:0060441: epithelial tube branching involved in lung morphogenesis
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:0097150: neuronal stem cell maintenance
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005667: transcription factor complex
GO:0005515: protein binding
GO:0000976: transcription regulatory region sequence-specific DNA binding
GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677: DNA binding
GO:0003682: chromatin binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0044212: transcription regulatory region DNA binding
GO:0035198: miRNA binding
GO:0043565: sequence-specific DNA binding
KEGG pathways ---

PubMed abstracts associated with SOX2

PMID Title Tumor Value
20309879 Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. no no
20596639 Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. no no
21178508 BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. no no
21927024 Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. yes no
22870217 Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma. no no
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