General Information
Gene ID | 6662 |
---|---|
Gene Symbol | SOX9 |
Gene Name | SRY (sex determining region Y)-box 9 |
Gene Type | protein-coding |
Cytoband | 17q23 |
Ensembl ID | ENSG00000125398 |
#miR regulators | 6 |
Omim ID | 114290 608160 |
Gene ontology |
GO:0001501: skeletal system development GO:0001502: cartilage condensation GO:0001503: ossification GO:0001658: branching involved in ureteric bud morphogenesis GO:0001708: cell fate specification GO:0001837: epithelial to mesenchymal transition GO:0001894: tissue homeostasis GO:0001934: positive regulation of protein phosphorylation GO:0001942: hair follicle development GO:0002053: positive regulation of mesenchymal cell proliferation GO:0002683: negative regulation of immune system process GO:0003170: heart valve development GO:0003179: heart valve morphogenesis GO:0003188: heart valve formation GO:0003203: endocardial cushion morphogenesis GO:0003413: chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003415: chondrocyte hypertrophy GO:0006334: nucleosome assembly GO:0007165: signal transduction GO:0006338: chromatin remodeling GO:0006461: protein complex assembly GO:0007173: epidermal growth factor receptor signaling pathway GO:0007283: spermatogenesis GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0008584: male gonad development GO:0010564: regulation of cell cycle process GO:0010634: positive regulation of epithelial cell migration GO:0014032: neural crest cell development GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade GO:0042981: regulation of apoptotic process GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0019100: male germ-line sex determination GO:0019933: cAMP-mediated signaling GO:0071260: cellular response to mechanical stimulus GO:0030155: regulation of cell adhesion GO:0030198: extracellular matrix organization GO:0030279: negative regulation of ossification GO:0030502: negative regulation of bone mineralization GO:0030850: prostate gland development GO:0030858: positive regulation of epithelial cell differentiation GO:0030879: mammary gland development GO:0030903: notochord development GO:0030916: otic vesicle formation GO:0031018: endocrine pancreas development GO:0032331: negative regulation of chondrocyte differentiation GO:0032332: positive regulation of chondrocyte differentiation GO:0035019: somatic stem cell maintenance GO:0035622: intrahepatic bile duct development GO:0042127: regulation of cell proliferation GO:0043491: protein kinase B signaling cascade GO:0045662: negative regulation of myoblast differentiation GO:0045732: positive regulation of protein catabolic process GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0046533: negative regulation of photoreceptor cell differentiation GO:0048709: oligodendrocyte differentiation GO:0050679: positive regulation of epithelial cell proliferation GO:0050680: negative regulation of epithelial cell proliferation GO:0051216: cartilage development GO:0060008: Sertoli cell differentiation GO:0060009: Sertoli cell development GO:0060018: astrocyte fate commitment GO:0060041: retina development in camera-type eye GO:0060174: limb bud formation GO:0060221: retinal rod cell differentiation GO:0060517: epithelial cell proliferation involved in prostatic bud elongation GO:0060729: intestinal epithelial structure maintenance GO:0060784: regulation of cell proliferation involved in tissue homeostasis GO:0061036: positive regulation of cartilage development GO:0061138: morphogenesis of a branching epithelium GO:0070168: negative regulation of biomineral tissue development GO:0070371: ERK1 and ERK2 cascade GO:0071300: cellular response to retinoic acid GO:0071347: cellular response to interleukin-1 GO:0071364: cellular response to epidermal growth factor stimulus GO:0071504: cellular response to heparin GO:0071560: cellular response to transforming growth factor beta stimulus GO:0072034: renal vesicle induction GO:0072190: ureter urothelium development GO:0072197: ureter morphogenesis GO:0072289: metanephric nephron tubule formation GO:0090090: negative regulation of canonical Wnt receptor signaling pathway GO:0090103: cochlea morphogenesis GO:0090184: positive regulation of kidney development GO:0090190: positive regulation of branching involved in ureteric bud morphogenesis GO:2000020: positive regulation of male gonad development GO:2000138: positive regulation of cell proliferation involved in heart morphogenesis GO:2000741: positive regulation of mesenchymal stem cell differentiation GO:0005634: nucleus GO:0005667: transcription factor complex GO:0043234: protein complex GO:0005515: protein binding GO:0001046: core promoter sequence-specific DNA binding GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001158: enhancer sequence-specific DNA binding GO:0003682: chromatin binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0004672: protein kinase activity GO:0008013: beta-catenin binding GO:0034236: protein kinase A catalytic subunit binding GO:0035326: enhancer binding GO:0043425: bHLH transcription factor binding |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
10491221 | The transcription factor Sox9 is involved in BMP-2 signaling. | no | no |
12673561 | Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. | yes | no |
19688969 | Prognostic implication of immunohistochemical Runx2 expression in osteosarcoma. | yes | yes |
20484142 | Sox9 expression is not limited to chondroid neoplasms: variable occurrence in other soft tissue and bone tumors with frequent expression by synovial sarcomas. | yes | no |
title | all | all |