Results for SOX9

General Information

Gene ID 6662
Gene Symbol SOX9
Gene Name SRY (sex determining region Y)-box 9
Gene Type protein-coding
Cytoband 17q23
Ensembl ID ENSG00000125398
#miR regulators 6
Omim ID 114290 608160
Gene ontology GO:0001501: skeletal system development
GO:0001502: cartilage condensation
GO:0001503: ossification
GO:0001658: branching involved in ureteric bud morphogenesis
GO:0001708: cell fate specification
GO:0001837: epithelial to mesenchymal transition
GO:0001894: tissue homeostasis
GO:0001934: positive regulation of protein phosphorylation
GO:0001942: hair follicle development
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0002683: negative regulation of immune system process
GO:0003170: heart valve development
GO:0003179: heart valve morphogenesis
GO:0003188: heart valve formation
GO:0003203: endocardial cushion morphogenesis
GO:0003413: chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0003415: chondrocyte hypertrophy
GO:0006334: nucleosome assembly
GO:0007165: signal transduction
GO:0006338: chromatin remodeling
GO:0006461: protein complex assembly
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007283: spermatogenesis
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0008584: male gonad development
GO:0010564: regulation of cell cycle process
GO:0010634: positive regulation of epithelial cell migration
GO:0014032: neural crest cell development
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0042981: regulation of apoptotic process
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0019100: male germ-line sex determination
GO:0019933: cAMP-mediated signaling
GO:0071260: cellular response to mechanical stimulus
GO:0030155: regulation of cell adhesion
GO:0030198: extracellular matrix organization
GO:0030279: negative regulation of ossification
GO:0030502: negative regulation of bone mineralization
GO:0030850: prostate gland development
GO:0030858: positive regulation of epithelial cell differentiation
GO:0030879: mammary gland development
GO:0030903: notochord development
GO:0030916: otic vesicle formation
GO:0031018: endocrine pancreas development
GO:0032331: negative regulation of chondrocyte differentiation
GO:0032332: positive regulation of chondrocyte differentiation
GO:0035019: somatic stem cell maintenance
GO:0035622: intrahepatic bile duct development
GO:0042127: regulation of cell proliferation
GO:0043491: protein kinase B signaling cascade
GO:0045662: negative regulation of myoblast differentiation
GO:0045732: positive regulation of protein catabolic process
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046533: negative regulation of photoreceptor cell differentiation
GO:0048709: oligodendrocyte differentiation
GO:0050679: positive regulation of epithelial cell proliferation
GO:0050680: negative regulation of epithelial cell proliferation
GO:0051216: cartilage development
GO:0060008: Sertoli cell differentiation
GO:0060009: Sertoli cell development
GO:0060018: astrocyte fate commitment
GO:0060041: retina development in camera-type eye
GO:0060174: limb bud formation
GO:0060221: retinal rod cell differentiation
GO:0060517: epithelial cell proliferation involved in prostatic bud elongation
GO:0060729: intestinal epithelial structure maintenance
GO:0060784: regulation of cell proliferation involved in tissue homeostasis
GO:0061036: positive regulation of cartilage development
GO:0061138: morphogenesis of a branching epithelium
GO:0070168: negative regulation of biomineral tissue development
GO:0070371: ERK1 and ERK2 cascade
GO:0071300: cellular response to retinoic acid
GO:0071347: cellular response to interleukin-1
GO:0071364: cellular response to epidermal growth factor stimulus
GO:0071504: cellular response to heparin
GO:0071560: cellular response to transforming growth factor beta stimulus
GO:0072034: renal vesicle induction
GO:0072190: ureter urothelium development
GO:0072197: ureter morphogenesis
GO:0072289: metanephric nephron tubule formation
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:0090103: cochlea morphogenesis
GO:0090184: positive regulation of kidney development
GO:0090190: positive regulation of branching involved in ureteric bud morphogenesis
GO:2000020: positive regulation of male gonad development
GO:2000138: positive regulation of cell proliferation involved in heart morphogenesis
GO:2000741: positive regulation of mesenchymal stem cell differentiation
GO:0005634: nucleus
GO:0005667: transcription factor complex
GO:0043234: protein complex
GO:0005515: protein binding
GO:0001046: core promoter sequence-specific DNA binding
GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001158: enhancer sequence-specific DNA binding
GO:0003682: chromatin binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004672: protein kinase activity
GO:0008013: beta-catenin binding
GO:0034236: protein kinase A catalytic subunit binding
GO:0035326: enhancer binding
GO:0043425: bHLH transcription factor binding
KEGG pathways ---

PubMed abstracts associated with SOX9

PMID Title Tumor Value
10491221 The transcription factor Sox9 is involved in BMP-2 signaling. no no
12673561 Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. yes no
19688969 Prognostic implication of immunohistochemical Runx2 expression in osteosarcoma. yes yes
20484142 Sox9 expression is not limited to chondroid neoplasms: variable occurrence in other soft tissue and bone tumors with frequent expression by synovial sarcomas. yes no
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