General Information
Gene ID | 6667 |
---|---|
Gene Symbol | SP1 |
Gene Name | Sp1 transcription factor |
Gene Type | protein-coding |
Cytoband | 12q13.1 |
Ensembl ID | ENSG00000185591 |
#miR regulators | 7 |
Omim ID | 189906 |
Gene ontology |
GO:0001503: ossification GO:0001829: trophectodermal cell differentiation GO:0001889: liver development GO:0001892: embryonic placenta development GO:0006351: transcription, DNA-dependent GO:0006355: regulation of transcription, DNA-dependent GO:0006367: transcription initiation from RNA polymerase II promoter GO:0007179: transforming growth factor beta receptor signaling pathway GO:0010467: gene expression GO:0045893: positive regulation of transcription, DNA-dependent GO:0019048: modulation by virus of host morphology or physiology GO:0030219: megakaryocyte differentiation GO:0030324: lung development GO:0043353: enucleate erythrocyte differentiation GO:0043923: positive regulation by host of viral transcription GO:0044255: cellular lipid metabolic process GO:0044281: small molecule metabolic process GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048596: embryonic camera-type eye morphogenesis GO:0048706: embryonic skeletal system development GO:0060136: embryonic process involved in female pregnancy GO:0060216: definitive hemopoiesis GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0032993: protein-DNA complex GO:0005515: protein binding GO:0000978: RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979: RNA polymerase II core promoter sequence-specific DNA binding GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001103: RNA polymerase II repressing transcription factor binding GO:0003677: DNA binding GO:0003690: double-stranded DNA binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0046872: metal ion binding GO:0008022: protein C-terminus binding GO:0008134: transcription factor binding GO:0044212: transcription regulatory region DNA binding GO:0035035: histone acetyltransferase binding GO:0035326: enhancer binding GO:0042803: protein homodimerization activity GO:0042826: histone deacetylase binding GO:0043425: bHLH transcription factor binding GO:0043565: sequence-specific DNA binding GO:0071837: HMG box domain binding |
KEGG pathways |
4350: TGF-beta signaling pathway 5016: Huntington's disease |
PMID | Title | Tumor | Value |
---|---|---|---|
8662647 | Transcriptional regulation of the SIS/PDGF-B gene in human osteosarcoma cells by the Sp family of transcription factors. | no | no |
9492043 | p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. | no | no |
12907249 | Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. | no | no |
16734381 | Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. | no | no |
24009496 | How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation | no | no |
23201449 | Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. | no | no |
title | all | all |