Results for SP1

General Information

Gene ID 6667
Gene Symbol SP1
Gene Name Sp1 transcription factor
Gene Type protein-coding
Cytoband 12q13.1
Ensembl ID ENSG00000185591
#miR regulators 7
Omim ID 189906
Gene ontology GO:0001503: ossification
GO:0001829: trophectodermal cell differentiation
GO:0001889: liver development
GO:0001892: embryonic placenta development
GO:0006351: transcription, DNA-dependent
GO:0006355: regulation of transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0010467: gene expression
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0019048: modulation by virus of host morphology or physiology
GO:0030219: megakaryocyte differentiation
GO:0030324: lung development
GO:0043353: enucleate erythrocyte differentiation
GO:0043923: positive regulation by host of viral transcription
GO:0044255: cellular lipid metabolic process
GO:0044281: small molecule metabolic process
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048596: embryonic camera-type eye morphogenesis
GO:0048706: embryonic skeletal system development
GO:0060136: embryonic process involved in female pregnancy
GO:0060216: definitive hemopoiesis
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0032993: protein-DNA complex
GO:0005515: protein binding
GO:0000978: RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979: RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103: RNA polymerase II repressing transcription factor binding
GO:0003677: DNA binding
GO:0003690: double-stranded DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0046872: metal ion binding
GO:0008022: protein C-terminus binding
GO:0008134: transcription factor binding
GO:0044212: transcription regulatory region DNA binding
GO:0035035: histone acetyltransferase binding
GO:0035326: enhancer binding
GO:0042803: protein homodimerization activity
GO:0042826: histone deacetylase binding
GO:0043425: bHLH transcription factor binding
GO:0043565: sequence-specific DNA binding
GO:0071837: HMG box domain binding
KEGG pathways 4350: TGF-beta signaling pathway
5016: Huntington's disease

PubMed abstracts associated with SP1

PMID Title Tumor Value
8662647 Transcriptional regulation of the SIS/PDGF-B gene in human osteosarcoma cells by the Sp family of transcription factors. no no
9492043 p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. no no
12907249 Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. no no
16734381 Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. no no
24009496 How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation no no
23201449 Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. no no
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