Results for SPARC

General Information

Gene ID 6678
Gene Symbol SPARC
Gene Name secreted protein, acidic, cysteine-rich (osteonectin)
Gene Type protein-coding
Cytoband 5q31.3-q32
Ensembl ID ENSG00000113140
#miR regulators 12
Omim ID 182120
Gene ontology GO:0001503: ossification
GO:0002576: platelet degranulation
GO:0007596: blood coagulation
GO:0007165: signal transduction
GO:0007507: heart development
GO:0009629: response to gravity
GO:0010288: response to lead ion
GO:0046686: response to cadmium ion
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0030324: lung development
GO:0032496: response to lipopolysaccharide
GO:0033591: response to L-ascorbic acid
GO:0034097: response to cytokine stimulus
GO:0042127: regulation of cell proliferation
GO:0043434: response to peptide hormone stimulus
GO:0045471: response to ethanol
GO:0048839: inner ear development
GO:0051384: response to glucocorticoid stimulus
GO:0051591: response to cAMP
GO:0051592: response to calcium ion
GO:0060348: bone development
GO:0071363: cellular response to growth factor stimulus
GO:0005576: extracellular region
GO:0005578: proteinaceous extracellular matrix
GO:0005604: basement membrane
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0031093: platelet alpha granule lumen
GO:0071682: endocytic vesicle lumen
GO:0005515: protein binding
GO:0005509: calcium ion binding
GO:0005518: collagen binding
GO:0050840: extracellular matrix binding
KEGG pathways ---

PubMed abstracts associated with SPARC

PMID Title Tumor Value
1468768 Evaluation of osteonectin as a diagnostic marker of osteogenic bone tumors. yes yes
1622861 Osteonectin in osteosarcomas: a marker for differential diagnosis and/or prognosis? yes no
2287591 The impact of osteonectin for differential diagnosis of bone tumors. An immunohistochemical approach. yes no
2496522 Immunocytochemical identification of osteogenic bone tumors by osteonectin antibodies. yes yes
2776495 Immunohistological demonstration of osteonectin in normal bone tissue and in bone tumors. yes yes
3165250 Immunohistochemical study of osteonectin in various types of osteosarcoma. yes yes
8166715 Osteonectin/SPARC regulates cellular secretion rates of fibronectin and laminin extracellular matrix proteins. no no
8717113 The impact of osteonectin for differential diagnosis of osteogenic bone tumors: an immunohistochemical and in situ hybridization approach. yes yes
9322601 Osteocalcin and osteonectin immunoreactivity in the diagnosis of osteosarcoma. yes yes
9923924 Osteocalcin and osteonectin immunoreactivity in extraskeletal osteosarcoma: a study of 28 cases. yes yes
11746520 Cellular and molecular properties associated with osteosarcoma cells. yes no
17022822 Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. yes no
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