Results for SPP1

General Information

Gene ID 6696
Gene Symbol SPP1
Gene Name secreted phosphoprotein 1
Gene Type protein-coding
Cytoband 4q22.1
Ensembl ID ENSG00000118785
#miR regulators 6
Omim ID 166490
Gene ontology GO:0001649: osteoblast differentiation
GO:0007155: cell adhesion
GO:0006954: inflammatory response
GO:0007566: embryo implantation
GO:0010811: positive regulation of cell-substrate adhesion
GO:0030198: extracellular matrix organization
GO:0030593: neutrophil chemotaxis
GO:0031214: biomineral tissue development
GO:0033280: response to vitamin D
GO:0045780: positive regulation of bone resorption
GO:0046697: decidualization
GO:0048545: response to steroid hormone stimulus
GO:0048685: negative regulation of collateral sprouting of intact axon in response to injury
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0031988: membrane-bounded vesicle
GO:0042995: cell projection
GO:0045177: apical part of cell
GO:0048471: perinuclear region of cytoplasm
GO:0005125: cytokine activity
GO:0050840: extracellular matrix binding
KEGG pathways 4510: Focal adhesion
4512: ECM-receptor interaction
4620: Toll-like receptor signaling pathway

PubMed abstracts associated with SPP1

PMID Title Tumor Value
7794813 Phenotypic modification of human osteosarcoma cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. no no
12232677 Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. no no
12237108 Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. no no
12404059 Expression of osteopontin and vascular endothelial growth factor in benign and malignant bone tumors. yes no
14706926 Effect of human granulocyte macrophage-colony stimulating factor on differentiation and apoptosis of the human osteosarcoma cell line SaOS-2. no no
14975209 Effect of human osteopontin on proliferation, transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells. no no
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. no no
15742288 Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. no no
15946696 Nicotine affects mineralized nodule formation by the human osteosarcoma cell line Saos-2. no no
17022822 Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. yes no
17952379 The inhibition of in vivo tumorigenesis of osteosarcoma (OS)-732 cells by antisense human osteopontin RNA. no yes
18838962 Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. no no
20465837 Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy. yes yes
23142238 Cell adhesion molecule 1 is a new osteoblastic cell adhesion molecule and a diagnostic marker for osteosarcoma. yes yes
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