Results for SRC

General Information

Gene ID 6714
Gene Symbol SRC
Gene Name v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
Gene Type protein-coding
Cytoband 20q12-q13
Ensembl ID ENSG00000197122
#miR regulators 7
Omim ID 190090
Gene ontology GO:0007596: blood coagulation
GO:0007155: cell adhesion
GO:0007165: signal transduction
GO:0007049: cell cycle
GO:0007172: signal complex assembly
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007243: intracellular protein kinase cascade
GO:0007265: Ras protein signal transduction
GO:0007411: axon guidance
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0016044: cellular membrane organization
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0019048: modulation by virus of host morphology or physiology
GO:0030168: platelet activation
GO:0030900: forebrain development
GO:0031295: T cell costimulation
GO:0032463: negative regulation of protein homooligomerization
GO:0033146: regulation of intracellular estrogen receptor signaling pathway
GO:0033625: positive regulation of integrin activation
GO:0038096: Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043114: regulation of vascular permeability
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393: regulation of protein binding
GO:0045087: innate immune response
GO:0045124: regulation of bone resorption
GO:0045453: bone resorption
GO:0046777: protein autophosphorylation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048477: oogenesis
GO:0050847: progesterone receptor signaling pathway
GO:0050900: leukocyte migration
GO:0051895: negative regulation of focal adhesion assembly
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0060065: uterus development
GO:0060444: branching involved in mammary gland duct morphogenesis
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0070555: response to interleukin-1
GO:0071393: cellular response to progesterone stimulus
GO:0071803: positive regulation of podosome assembly
GO:0090263: positive regulation of canonical Wnt receptor signaling pathway
GO:2000811: negative regulation of anoikis
GO:2001237: negative regulation of extrinsic apoptotic signaling pathway
GO:2001243: negative regulation of intrinsic apoptotic signaling pathway
GO:0005886: plasma membrane
GO:0005764: lysosome
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005743: mitochondrial inner membrane
GO:0005770: late endosome
GO:0005856: cytoskeleton
GO:0005901: caveola
GO:0005515: protein binding
GO:0005102: receptor binding
GO:0004672: protein kinase activity
GO:0004713: protein tyrosine kinase activity
GO:0004715: non-membrane spanning protein tyrosine kinase activity
GO:0005070: SH3/SH2 adaptor activity
GO:0046875: ephrin receptor binding
GO:0005178: integrin binding
GO:0005524: ATP binding
GO:0042802: identical protein binding
GO:0016301: kinase activity
GO:0020037: heme binding
GO:0042169: SH2 domain binding
GO:0044325: ion channel binding
GO:0051219: phosphoprotein binding
KEGG pathways 4012: ErbB signaling pathway
4144: Endocytosis
4370: VEGF signaling pathway
4510: Focal adhesion
4520: Adherens junction
4530: Tight junction
4540: Gap junction
4912: GnRH signaling pathway
5100: Bacterial invasion of epithelial cells
5120: Epithelial cell signaling in Helicobacter pylori infection

PubMed abstracts associated with SRC

PMID Title Tumor Value
15870699 Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. no no
16421247 CD99 acts as an oncosuppressor in osteosarcoma. no no
16759849 PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation. no no
17699771 Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. no yes
18171692 Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. no no
19284568 Characterization of STAT3 activation and expression in canine and human osteosarcoma. no no
20970221 2-Hydroxypropyl-?-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. no no
21149578 Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63. no no
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