Results for BRCA1

General Information

Gene ID 672
Gene Symbol BRCA1
Gene Name breast cancer 1, early onset
Gene Type protein-coding
Cytoband 17q21
Ensembl ID ENSG00000012048
#miR regulators 1
Omim ID 113705 604370 614320
Gene ontology GO:0007059: chromosome segregation
GO:0000724: double-strand break repair via homologous recombination
GO:0006915: apoptotic process
GO:0016567: protein ubiquitination
GO:0006281: DNA repair
GO:0006301: postreplication repair
GO:0006302: double-strand break repair
GO:0006357: regulation of transcription from RNA polymerase II promoter
GO:0006359: regulation of transcription from RNA polymerase III promoter
GO:0006633: fatty acid biosynthetic process
GO:0006974: response to DNA damage stimulus
GO:0006978: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007049: cell cycle
GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212: response to ionizing radiation
GO:0042981: regulation of apoptotic process
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0030521: androgen receptor signaling pathway
GO:0031398: positive regulation of protein ubiquitination
GO:0031572: G2 DNA damage checkpoint
GO:0034446: substrate adhesion-dependent cell spreading
GO:0035066: positive regulation of histone acetylation
GO:0042127: regulation of cell proliferation
GO:0043627: response to estrogen stimulus
GO:0045717: negative regulation of fatty acid biosynthetic process
GO:0045739: positive regulation of DNA repair
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046600: negative regulation of centriole replication
GO:0051571: positive regulation of histone H3-K4 methylation
GO:0051573: negative regulation of histone H3-K9 methylation
GO:0051865: protein autoubiquitination
GO:0070512: positive regulation of histone H4-K20 methylation
GO:0071158: positive regulation of cell cycle arrest
GO:0071681: cellular response to indole-3-methanol
GO:0085020: protein K6-linked ubiquitination
GO:2000145: regulation of cell motility
GO:2000617: positive regulation of histone H3-K9 acetylation
GO:2000620: positive regulation of histone H4-K16 acetylation
GO:0005886: plasma membrane
GO:0000151: ubiquitin ligase complex
GO:0001726: ruffle
GO:0030529: ribonucleoprotein complex
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005694: chromosome
GO:0005925: focal adhesion
GO:0008274: gamma-tubulin ring complex
GO:0031436: BRCA1-BARD1 complex
GO:0031941: filamentous actin
GO:0043234: protein complex
GO:0070531: BRCA1-A complex
GO:0005515: protein binding
GO:0003677: DNA binding
GO:0003713: transcription coactivator activity
GO:0003723: RNA binding
GO:0004842: ubiquitin-protein ligase activity
GO:0008270: zinc ion binding
GO:0044212: transcription regulatory region DNA binding
GO:0015631: tubulin binding
GO:0019899: enzyme binding
GO:0031625: ubiquitin protein ligase binding
GO:0050681: androgen receptor binding
KEGG pathways 4120: Ubiquitin mediated proteolysis

PubMed abstracts associated with BRCA1

PMID Title Tumor Value
19559722 Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. no no
title all all