Results for STAT1

General Information

Gene ID 6772
Gene Symbol STAT1
Gene Name signal transducer and activator of transcription 1, 91kDa
Gene Type protein-coding
Cytoband 2q32.2
Ensembl ID ENSG00000115415
#miR regulators 9
Omim ID 209950 600555 613796 614162
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001937: negative regulation of endothelial cell proliferation
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0003340: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007259: JAK-STAT cascade
GO:0008015: blood circulation
GO:0042981: regulation of apoptotic process
GO:0016525: negative regulation of angiogenesis
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0019048: modulation by virus of host morphology or physiology
GO:0019221: cytokine-mediated signaling pathway
GO:0031663: lipopolysaccharide-mediated signaling pathway
GO:0033209: tumor necrosis factor-mediated signaling pathway
GO:0034097: response to cytokine stimulus
GO:0035458: cellular response to interferon-beta
GO:0043124: negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043330: response to exogenous dsRNA
GO:0043434: response to peptide hormone stimulus
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0051591: response to cAMP
GO:0051607: defense response to virus
GO:0060333: interferon-gamma-mediated signaling pathway
GO:0060334: regulation of interferon-gamma-mediated signaling pathway
GO:0060337: type I interferon-mediated signaling pathway
GO:0060338: regulation of type I interferon-mediated signaling pathway
GO:0060397: JAK-STAT cascade involved in growth hormone signaling pathway
GO:0061326: renal tubule development
GO:0072136: metanephric mesenchymal cell proliferation involved in metanephros development
GO:0072162: metanephric mesenchymal cell differentiation
GO:0072308: negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:0000790: nuclear chromatin
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005730: nucleolus
GO:0030424: axon
GO:0030425: dendrite
GO:0005515: protein binding
GO:0000978: RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979: RNA polymerase II core promoter sequence-specific DNA binding
GO:0000983: RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0005509: calcium ion binding
GO:0003690: double-stranded DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0004871: signal transducer activity
GO:0005164: tumor necrosis factor receptor binding
GO:0019899: enzyme binding
GO:0042803: protein homodimerization activity
KEGG pathways 4062: Chemokine signaling pathway
4380: Osteoclast differentiation
4620: Toll-like receptor signaling pathway
4630: Jak-STAT signaling pathway
5140: Leishmaniasis
5145: Toxoplasmosis
5160: Hepatitis C
5200: Pathways in cancer
5212: Pancreatic cancer

PubMed abstracts associated with STAT1

PMID Title Tumor Value
11451946 Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation. no no
15055356 Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line. no no
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