Results for STAT3

General Information

Gene ID 6774
Gene Symbol STAT3
Gene Name signal transducer and activator of transcription 3 (acute-phase response factor)
Gene Type protein-coding
Cytoband 17q21.31
Ensembl ID ENSG00000168610
#miR regulators 20
Omim ID 102582 147060
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001659: temperature homeostasis
GO:0001754: eye photoreceptor cell differentiation
GO:0006953: acute-phase response
GO:0006606: protein import into nucleus
GO:0007165: signal transduction
GO:0006355: regulation of transcription, DNA-dependent
GO:0006357: regulation of transcription from RNA polymerase II promoter
GO:0006928: cellular component movement
GO:0007259: JAK-STAT cascade
GO:0007399: nervous system development
GO:0008283: cell proliferation
GO:0042493: response to drug
GO:0016310: phosphorylation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0019048: modulation by virus of host morphology or physiology
GO:0019221: cytokine-mediated signaling pathway
GO:0019827: stem cell maintenance
GO:0019953: sexual reproduction
GO:0030522: intracellular receptor signaling pathway
GO:0032355: response to estradiol stimulus
GO:0032870: cellular response to hormone stimulus
GO:0040014: regulation of multicellular organism growth
GO:0042593: glucose homeostasis
GO:0042755: eating behavior
GO:0045471: response to ethanol
GO:0045747: positive regulation of Notch signaling pathway
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048708: astrocyte differentiation
GO:0060019: radial glial cell differentiation
GO:0060396: growth hormone receptor signaling pathway
GO:0060397: JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070102: interleukin-6-mediated signaling pathway
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005515: protein binding
GO:0001103: RNA polymerase II repressing transcription factor binding
GO:0005509: calcium ion binding
GO:0003677: DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0004879: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004871: signal transducer activity
GO:0046983: protein dimerization activity
GO:0008134: transcription factor binding
GO:0044212: transcription regulatory region DNA binding
GO:0019901: protein kinase binding
GO:0019903: protein phosphatase binding
GO:0031730: CCR5 chemokine receptor binding
GO:0035259: glucocorticoid receptor binding
GO:0043565: sequence-specific DNA binding
KEGG pathways 4062: Chemokine signaling pathway
4630: Jak-STAT signaling pathway
4920: Adipocytokine signaling pathway
5145: Toxoplasmosis
5160: Hepatitis C
5200: Pathways in cancer
5212: Pancreatic cancer
5221: Acute myeloid leukemia

PubMed abstracts associated with STAT3

PMID Title Tumor Value
14719113 Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells. no no
17598902 Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. yes no
19212684 The expression of epidermal growth factor receptor and its downstream signaling molecules in osteosarcoma. yes yes
19284568 Characterization of STAT3 activation and expression in canine and human osteosarcoma. no no
20063378 Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis. yes yes
20459702 Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. yes no
20546860 Clinical value of signal transducers and activators of transcription 3 (STAT3) gene expression in human osteosarcoma. yes no
20596639 Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. no no
21340507 Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. no no
21443800 The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. no no
21481226 Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. no no
21666078 MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. yes no
22093834 miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. yes no
22212432 Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells. no no
22743617 STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. no no
22926753 SC-1, a sorafenib derivative, shows anti-tumor effects in osteogenic sarcoma cells. no no
23313376 Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. no no
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