General Information
| Gene ID | 7015 |
|---|---|
| Gene Symbol | TERT |
| Gene Name | telomerase reverse transcriptase |
| Gene Type | protein-coding |
| Cytoband | 5p15.33 |
| Ensembl ID | ENSG00000164362 |
| #miR regulators | 1 |
| Omim ID | 127550 178500 187270 601626 609135 613989 614742 615134 |
| Gene ontology |
GO:0000723: telomere maintenance GO:0007004: telomere maintenance via telomerase GO:0022616: DNA strand elongation GO:0032203: telomere formation via telomerase GO:0090399: replicative senescence GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0000781: chromosome, telomeric region GO:0000783: nuclear telomere cap complex GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005697: telomerase holoenzyme complex GO:0005730: nucleolus GO:0016605: PML body GO:0005515: protein binding GO:0003720: telomerase activity GO:0003721: telomeric template RNA reverse transcriptase activity GO:0046872: metal ion binding GO:0042162: telomeric DNA binding GO:0042803: protein homodimerization activity GO:0070034: telomeric RNA binding |
| KEGG pathways | --- |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 12943619 | Telomerase, p53 and PCNA activity in osteosarcoma. | yes | yes |
| 15365076 | Telomerase expression predicts unfavorable outcome in osteosarcoma. | yes | yes |
| 17981215 | Identification of cryptic microaberrations in osteosarcoma by high-definition oligonucleotide array comparative genomic hybridization. | no | no |
| 19160414 | Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. | no | no |
| 19900100 | Immunohistochemistry for human telomerase reverse transcriptase catalytic subunit (hTERT): a study of 143 benign and malignant soft tissue and bone tumours. | yes | no |
| title | all | all |