General Information
| Gene ID | 7039 |
|---|---|
| Gene Symbol | TGFA |
| Gene Name | transforming growth factor, alpha |
| Gene Type | protein-coding |
| Cytoband | 2p13 |
| Ensembl ID | ENSG00000163235 |
| #miR regulators | 10 |
| Omim ID | 190170 |
| Gene ontology |
GO:0000165: MAPK cascade GO:0000187: activation of MAPK activity GO:0001525: angiogenesis GO:0045741: positive regulation of epidermal growth factor-activated receptor activity GO:0007173: epidermal growth factor receptor signaling pathway GO:0043066: negative regulation of apoptotic process GO:0008283: cell proliferation GO:0042493: response to drug GO:0042060: wound healing GO:0045840: positive regulation of mitosis GO:0050679: positive regulation of epithelial cell proliferation GO:0051781: positive regulation of cell division GO:0060749: mammary gland alveolus development GO:0005886: plasma membrane GO:0016021: integral to membrane GO:0005615: extracellular space GO:0005634: nucleus GO:0009986: cell surface GO:0016323: basolateral plasma membrane GO:0031410: cytoplasmic vesicle GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0001948: glycoprotein binding GO:0004708: MAP kinase kinase activity GO:0005154: epidermal growth factor receptor binding GO:0008083: growth factor activity |
| KEGG pathways |
4012: ErbB signaling pathway 5200: Pathways in cancer 5211: Renal cell carcinoma 5212: Pancreatic cancer 5214: Glioma 5215: Prostate cancer 5223: Non-small cell lung cancer |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 1586971 | Roles of various growth factors in growth of human osteosarcoma cells which can grow in protein-free medium. | no | no |
| 14669798 | Biological properties and gene expression associated with metastatic potential of human osteosarcoma. | no | no |
| 23631646 | MicroRNA-376c inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alpha. | yes | no |
| title | all | all |