Results for TGFB1

General Information

Gene ID 7040
Gene Symbol TGFB1
Gene Name transforming growth factor, beta 1
Gene Type protein-coding
Cytoband 19q13.1
Ensembl ID ENSG00000105329
#miR regulators ---
Omim ID 131300 190180 219700
Gene ontology GO:0000060: protein import into nucleus, translocation
GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000165: MAPK cascade
GO:0016049: cell growth
GO:0001657: ureteric bud development
GO:0001666: response to hypoxia
GO:0001837: epithelial to mesenchymal transition
GO:0001933: negative regulation of protein phosphorylation
GO:0001934: positive regulation of protein phosphorylation
GO:0002028: regulation of sodium ion transport
GO:0002062: chondrocyte differentiation
GO:0002244: hematopoietic progenitor cell differentiation
GO:0002248: connective tissue replacement involved in inflammatory response wound healing
GO:0002460: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002513: tolerance induction to self antigen
GO:0002576: platelet degranulation
GO:0007596: blood coagulation
GO:0006468: protein phosphorylation
GO:0006611: protein export from nucleus
GO:0006754: ATP biosynthetic process
GO:0006796: phosphate-containing compound metabolic process
GO:0006874: cellular calcium ion homeostasis
GO:0006954: inflammatory response
GO:0007050: cell cycle arrest
GO:0007093: mitotic cell cycle checkpoint
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007182: common-partner SMAD protein phosphorylation
GO:0007183: SMAD protein complex assembly
GO:0007184: SMAD protein import into nucleus
GO:0009790: embryo development
GO:0007406: negative regulation of neuroblast proliferation
GO:0007435: salivary gland morphogenesis
GO:0007492: endoderm development
GO:0048535: lymph node development
GO:0007565: female pregnancy
GO:0007568: aging
GO:0008156: negative regulation of DNA replication
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008354: germ cell migration
GO:0009314: response to radiation
GO:0042493: response to drug
GO:0009611: response to wounding
GO:0009749: response to glucose stimulus
GO:0009817: defense response to fungus, incompatible interaction
GO:0010575: positive regulation vascular endothelial growth factor production
GO:0010628: positive regulation of gene expression
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0010742: macrophage derived foam cell differentiation
GO:0010763: positive regulation of fibroblast migration
GO:0010800: positive regulation of peptidyl-threonine phosphorylation
GO:0010862: positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936: negative regulation of macrophage cytokine production
GO:0016202: regulation of striated muscle tissue development
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0017015: regulation of transforming growth factor beta receptor signaling pathway
GO:0019048: modulation by virus of host morphology or physiology
GO:0019049: evasion or tolerance of host defenses by virus
GO:0019058: viral infectious cycle
GO:0022408: negative regulation of cell-cell adhesion
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0030214: hyaluronan catabolic process
GO:0030279: negative regulation of ossification
GO:0030308: negative regulation of cell growth
GO:0030334: regulation of cell migration
GO:0030335: positive regulation of cell migration
GO:0030501: positive regulation of bone mineralization
GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031065: positive regulation of histone deacetylation
GO:0031100: organ regeneration
GO:0031334: positive regulation of protein complex assembly
GO:0031536: positive regulation of exit from mitosis
GO:0031663: lipopolysaccharide-mediated signaling pathway
GO:0032270: positive regulation of cellular protein metabolic process
GO:0032355: response to estradiol stimulus
GO:0032570: response to progesterone stimulus
GO:0032740: positive regulation of interleukin-17 production
GO:0032801: receptor catabolic process
GO:0032930: positive regulation of superoxide anion generation
GO:0032943: mononuclear cell proliferation
GO:0032967: positive regulation of collagen biosynthetic process
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0033280: response to vitamin D
GO:0034616: response to laminar fluid shear stress
GO:0035066: positive regulation of histone acetylation
GO:0035307: positive regulation of protein dephosphorylation
GO:0042130: negative regulation of T cell proliferation
GO:0042306: regulation of protein import into nucleus
GO:0042307: positive regulation of protein import into nucleus
GO:0042482: positive regulation of odontogenesis
GO:0042552: myelination
GO:0043011: myeloid dendritic cell differentiation
GO:0043029: T cell homeostasis
GO:0043065: positive regulation of apoptotic process
GO:0043406: positive regulation of MAP kinase activity
GO:0043491: protein kinase B signaling cascade
GO:0043536: positive regulation of blood vessel endothelial cell migration
GO:0043537: negative regulation of blood vessel endothelial cell migration
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0043932: ossification involved in bone remodeling
GO:0045066: regulatory T cell differentiation
GO:0045216: cell-cell junction organization
GO:0045599: negative regulation of fat cell differentiation
GO:0045662: negative regulation of myoblast differentiation
GO:0045786: negative regulation of cell cycle
GO:0045930: negative regulation of mitotic cell cycle
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046732: active induction of host immune response by virus
GO:0048298: positive regulation of isotype switching to IgA isotypes
GO:0048565: digestive tract development
GO:0048642: negative regulation of skeletal muscle tissue development
GO:0048839: inner ear development
GO:0050679: positive regulation of epithelial cell proliferation
GO:0050680: negative regulation of epithelial cell proliferation
GO:0050714: positive regulation of protein secretion
GO:0050765: negative regulation of phagocytosis
GO:0050777: negative regulation of immune response
GO:0050921: positive regulation of chemotaxis
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051098: regulation of binding
GO:0051101: regulation of DNA binding
GO:0051152: positive regulation of smooth muscle cell differentiation
GO:0051280: negative regulation of release of sequestered calcium ion into cytosol
GO:0051781: positive regulation of cell division
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0060325: face morphogenesis
GO:0060364: frontal suture morphogenesis
GO:0060389: pathway-restricted SMAD protein phosphorylation
GO:0060391: positive regulation of SMAD protein import into nucleus
GO:0060744: mammary gland branching involved in thelarche
GO:0060751: branch elongation involved in mammary gland duct branching
GO:0060762: regulation of branching involved in mammary gland duct morphogenesis
GO:0061035: regulation of cartilage development
GO:0070306: lens fiber cell differentiation
GO:0070723: response to cholesterol
GO:0071158: positive regulation of cell cycle arrest
GO:0071407: cellular response to organic cyclic compound
GO:0071549: cellular response to dexamethasone stimulus
GO:0085029: extracellular matrix assembly
GO:0090190: positive regulation of branching involved in ureteric bud morphogenesis
GO:0097191: extrinsic apoptotic signaling pathway
GO:1900126: negative regulation of hyaluronan biosynthetic process
GO:1901666: positive regulation of NAD+ ADP-ribosyltransferase activity
GO:2000679: positive regulation of transcription regulatory region DNA binding
GO:0005576: extracellular region
GO:0005578: proteinaceous extracellular matrix
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005796: Golgi lumen
GO:0005902: microvillus
GO:0009986: cell surface
GO:0030424: axon
GO:0031093: platelet alpha granule lumen
GO:0043025: neuronal cell body
GO:0005515: protein binding
GO:0005114: type II transforming growth factor beta receptor binding
GO:0008083: growth factor activity
GO:0019899: enzyme binding
GO:0042803: protein homodimerization activity
GO:0046982: protein heterodimerization activity
GO:0047485: protein N-terminus binding
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4110: Cell cycle
4144: Endocytosis
4350: TGF-beta signaling pathway
4380: Osteoclast differentiation
4672: Intestinal immune network for IgA production
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5144: Malaria
5145: Toxoplasmosis
5146: Amoebiasis
5200: Pathways in cancer
5210: Colorectal cancer
5211: Renal cell carcinoma
5212: Pancreatic cancer
5220: Chronic myeloid leukemia
5323: Rheumatoid arthritis
5410: Hypertrophic cardiomyopathy (HCM)
5414: Dilated cardiomyopathy

PubMed abstracts associated with TGFB1

PMID Title Tumor Value
1481722 The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63. no no
2600089 Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. no no
7641470 The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. no no
7768643 Mediation of glucocorticoid receptor function by the activation of latent transforming growth factor beta 1 in MG-63 human osteosarcoma cells. no no
7817811 Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. no no
7835281 Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production. no no
8050825 Expression of transforming growth factor-beta (TGF-beta) receptors, TGF-beta 1 and TGF-beta 2 production and autocrine growth control in osteosarcoma cells. no no
8080687 Suramin inhibits growth and transforming growth factor-beta 1 (TGF-beta 1) binding in osteosarcoma cell lines. no no
9252243 TGF-beta1 selectively suppresses PDGF receptor signaling pathways in MG-63 human osteosarcoma cell. no no
9605020 Relation between histological intensity of transforming growth factor-beta isoforms in human osteosarcoma and the rate of lung metastasis. yes yes
9771482 Expression of transforming growth factor beta isoforms in osteosarcoma variants: association of TGF beta 1 with high-grade osteosarcomas. yes no
10390144 Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells. no no
11874241 Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells. no no
12973938 Construction of antisense transforming growth factor beta 1 gene and its effect on the proliferation by expression in osteosarcoma cells. no no
14633705 SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. no no
15174116 Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. no no
15250258 Effects of TGF beta1 autocrine blockage on osteosarcoma cells. no no
15753370 An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. yes no
16475708 Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. no no
17410535 Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. yes no
19505574 C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. no no
21801875 Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. yes no
21945933 RLIM interacts with Smurf2 and promotes TGF-? induced U2OS cell migration. no no
22147650 Prion proteins (PRNP and PRND) are over-expressed in osteosarcoma. yes no
23167426 Clinical predictive value of serum angiogenic factor in patients with osteosarcoma. yes yes
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