General Information
Gene ID | 7040 |
---|---|
Gene Symbol | TGFB1 |
Gene Name | transforming growth factor, beta 1 |
Gene Type | protein-coding |
Cytoband | 19q13.1 |
Ensembl ID | ENSG00000105329 |
#miR regulators | --- |
Omim ID | 131300 190180 219700 |
Gene ontology |
GO:0000060: protein import into nucleus, translocation GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0000165: MAPK cascade GO:0016049: cell growth GO:0001657: ureteric bud development GO:0001666: response to hypoxia GO:0001837: epithelial to mesenchymal transition GO:0001933: negative regulation of protein phosphorylation GO:0001934: positive regulation of protein phosphorylation GO:0002028: regulation of sodium ion transport GO:0002062: chondrocyte differentiation GO:0002244: hematopoietic progenitor cell differentiation GO:0002248: connective tissue replacement involved in inflammatory response wound healing GO:0002460: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002513: tolerance induction to self antigen GO:0002576: platelet degranulation GO:0007596: blood coagulation GO:0006468: protein phosphorylation GO:0006611: protein export from nucleus GO:0006754: ATP biosynthetic process GO:0006796: phosphate-containing compound metabolic process GO:0006874: cellular calcium ion homeostasis GO:0006954: inflammatory response GO:0007050: cell cycle arrest GO:0007093: mitotic cell cycle checkpoint GO:0007173: epidermal growth factor receptor signaling pathway GO:0007179: transforming growth factor beta receptor signaling pathway GO:0007182: common-partner SMAD protein phosphorylation GO:0007183: SMAD protein complex assembly GO:0007184: SMAD protein import into nucleus GO:0009790: embryo development GO:0007406: negative regulation of neuroblast proliferation GO:0007435: salivary gland morphogenesis GO:0007492: endoderm development GO:0048535: lymph node development GO:0007565: female pregnancy GO:0007568: aging GO:0008156: negative regulation of DNA replication GO:0008284: positive regulation of cell proliferation GO:0008285: negative regulation of cell proliferation GO:0008354: germ cell migration GO:0009314: response to radiation GO:0042493: response to drug GO:0009611: response to wounding GO:0009749: response to glucose stimulus GO:0009817: defense response to fungus, incompatible interaction GO:0010575: positive regulation vascular endothelial growth factor production GO:0010628: positive regulation of gene expression GO:0010718: positive regulation of epithelial to mesenchymal transition GO:0010742: macrophage derived foam cell differentiation GO:0010763: positive regulation of fibroblast migration GO:0010800: positive regulation of peptidyl-threonine phosphorylation GO:0010862: positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010936: negative regulation of macrophage cytokine production GO:0016202: regulation of striated muscle tissue development GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0017015: regulation of transforming growth factor beta receptor signaling pathway GO:0019048: modulation by virus of host morphology or physiology GO:0019049: evasion or tolerance of host defenses by virus GO:0019058: viral infectious cycle GO:0022408: negative regulation of cell-cell adhesion GO:0030168: platelet activation GO:0030198: extracellular matrix organization GO:0030214: hyaluronan catabolic process GO:0030279: negative regulation of ossification GO:0030308: negative regulation of cell growth GO:0030334: regulation of cell migration GO:0030335: positive regulation of cell migration GO:0030501: positive regulation of bone mineralization GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway GO:0031065: positive regulation of histone deacetylation GO:0031100: organ regeneration GO:0031334: positive regulation of protein complex assembly GO:0031536: positive regulation of exit from mitosis GO:0031663: lipopolysaccharide-mediated signaling pathway GO:0032270: positive regulation of cellular protein metabolic process GO:0032355: response to estradiol stimulus GO:0032570: response to progesterone stimulus GO:0032740: positive regulation of interleukin-17 production GO:0032801: receptor catabolic process GO:0032930: positive regulation of superoxide anion generation GO:0032943: mononuclear cell proliferation GO:0032967: positive regulation of collagen biosynthetic process GO:0033138: positive regulation of peptidyl-serine phosphorylation GO:0033280: response to vitamin D GO:0034616: response to laminar fluid shear stress GO:0035066: positive regulation of histone acetylation GO:0035307: positive regulation of protein dephosphorylation GO:0042130: negative regulation of T cell proliferation GO:0042306: regulation of protein import into nucleus GO:0042307: positive regulation of protein import into nucleus GO:0042482: positive regulation of odontogenesis GO:0042552: myelination GO:0043011: myeloid dendritic cell differentiation GO:0043029: T cell homeostasis GO:0043065: positive regulation of apoptotic process GO:0043406: positive regulation of MAP kinase activity GO:0043491: protein kinase B signaling cascade GO:0043536: positive regulation of blood vessel endothelial cell migration GO:0043537: negative regulation of blood vessel endothelial cell migration GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity GO:0043932: ossification involved in bone remodeling GO:0045066: regulatory T cell differentiation GO:0045216: cell-cell junction organization GO:0045599: negative regulation of fat cell differentiation GO:0045662: negative regulation of myoblast differentiation GO:0045786: negative regulation of cell cycle GO:0045930: negative regulation of mitotic cell cycle GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0046732: active induction of host immune response by virus GO:0048298: positive regulation of isotype switching to IgA isotypes GO:0048565: digestive tract development GO:0048642: negative regulation of skeletal muscle tissue development GO:0048839: inner ear development GO:0050679: positive regulation of epithelial cell proliferation GO:0050680: negative regulation of epithelial cell proliferation GO:0050714: positive regulation of protein secretion GO:0050765: negative regulation of phagocytosis GO:0050777: negative regulation of immune response GO:0050921: positive regulation of chemotaxis GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0051098: regulation of binding GO:0051101: regulation of DNA binding GO:0051152: positive regulation of smooth muscle cell differentiation GO:0051280: negative regulation of release of sequestered calcium ion into cytosol GO:0051781: positive regulation of cell division GO:0051897: positive regulation of protein kinase B signaling cascade GO:0060325: face morphogenesis GO:0060364: frontal suture morphogenesis GO:0060389: pathway-restricted SMAD protein phosphorylation GO:0060391: positive regulation of SMAD protein import into nucleus GO:0060744: mammary gland branching involved in thelarche GO:0060751: branch elongation involved in mammary gland duct branching GO:0060762: regulation of branching involved in mammary gland duct morphogenesis GO:0061035: regulation of cartilage development GO:0070306: lens fiber cell differentiation GO:0070723: response to cholesterol GO:0071158: positive regulation of cell cycle arrest GO:0071407: cellular response to organic cyclic compound GO:0071549: cellular response to dexamethasone stimulus GO:0085029: extracellular matrix assembly GO:0090190: positive regulation of branching involved in ureteric bud morphogenesis GO:0097191: extrinsic apoptotic signaling pathway GO:1900126: negative regulation of hyaluronan biosynthetic process GO:1901666: positive regulation of NAD+ ADP-ribosyltransferase activity GO:2000679: positive regulation of transcription regulatory region DNA binding GO:0005576: extracellular region GO:0005578: proteinaceous extracellular matrix GO:0005615: extracellular space GO:0005634: nucleus GO:0005737: cytoplasm GO:0005796: Golgi lumen GO:0005902: microvillus GO:0009986: cell surface GO:0030424: axon GO:0031093: platelet alpha granule lumen GO:0043025: neuronal cell body GO:0005515: protein binding GO:0005114: type II transforming growth factor beta receptor binding GO:0008083: growth factor activity GO:0019899: enzyme binding GO:0042803: protein homodimerization activity GO:0046982: protein heterodimerization activity GO:0047485: protein N-terminus binding |
KEGG pathways |
4010: MAPK signaling pathway 4060: Cytokine-cytokine receptor interaction 4110: Cell cycle 4144: Endocytosis 4350: TGF-beta signaling pathway 4380: Osteoclast differentiation 4672: Intestinal immune network for IgA production 5140: Leishmaniasis 5142: Chagas disease (American trypanosomiasis) 5144: Malaria 5145: Toxoplasmosis 5146: Amoebiasis 5200: Pathways in cancer 5210: Colorectal cancer 5211: Renal cell carcinoma 5212: Pancreatic cancer 5220: Chronic myeloid leukemia 5323: Rheumatoid arthritis 5410: Hypertrophic cardiomyopathy (HCM) 5414: Dilated cardiomyopathy |
PMID | Title | Tumor | Value |
---|---|---|---|
1481722 | The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63. | no | no |
2600089 | Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. | no | no |
7641470 | The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. | no | no |
7768643 | Mediation of glucocorticoid receptor function by the activation of latent transforming growth factor beta 1 in MG-63 human osteosarcoma cells. | no | no |
7817811 | Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. | no | no |
7835281 | Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production. | no | no |
8050825 | Expression of transforming growth factor-beta (TGF-beta) receptors, TGF-beta 1 and TGF-beta 2 production and autocrine growth control in osteosarcoma cells. | no | no |
8080687 | Suramin inhibits growth and transforming growth factor-beta 1 (TGF-beta 1) binding in osteosarcoma cell lines. | no | no |
9252243 | TGF-beta1 selectively suppresses PDGF receptor signaling pathways in MG-63 human osteosarcoma cell. | no | no |
9605020 | Relation between histological intensity of transforming growth factor-beta isoforms in human osteosarcoma and the rate of lung metastasis. | yes | yes |
9771482 | Expression of transforming growth factor beta isoforms in osteosarcoma variants: association of TGF beta 1 with high-grade osteosarcomas. | yes | no |
10390144 | Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells. | no | no |
11874241 | Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells. | no | no |
12973938 | Construction of antisense transforming growth factor beta 1 gene and its effect on the proliferation by expression in osteosarcoma cells. | no | no |
14633705 | SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. | no | no |
15174116 | Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. | no | no |
15250258 | Effects of TGF beta1 autocrine blockage on osteosarcoma cells. | no | no |
15753370 | An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. | yes | no |
16475708 | Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. | no | no |
17410535 | Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. | yes | no |
19505574 | C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. | no | no |
21801875 | Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. | yes | no |
21945933 | RLIM interacts with Smurf2 and promotes TGF-β induced U2OS cell migration. | no | no |
22147650 | Prion proteins (PRNP and PRND) are over-expressed in osteosarcoma. | yes | no |
23167426 | Clinical predictive value of serum angiogenic factor in patients with osteosarcoma. | yes | yes |
title | all | all |