Results for TGFB3

General Information

Gene ID 7043
Gene Symbol TGFB3
Gene Name transforming growth factor, beta 3
Gene Type protein-coding
Cytoband 14q24
Ensembl ID ENSG00000119699
#miR regulators 6
Omim ID 107970 190230
Gene ontology GO:0000187: activation of MAPK activity
GO:0016049: cell growth
GO:0001666: response to hypoxia
GO:0001701: in utero embryonic development
GO:0002576: platelet degranulation
GO:0007596: blood coagulation
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007184: SMAD protein import into nucleus
GO:0007435: salivary gland morphogenesis
GO:0007565: female pregnancy
GO:0007568: aging
GO:0008156: negative regulation of DNA replication
GO:0008285: negative regulation of cell proliferation
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0010862: positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936: negative regulation of macrophage cytokine production
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0022601: menstrual cycle phase
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0030501: positive regulation of bone mineralization
GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030879: mammary gland development
GO:0032570: response to progesterone stimulus
GO:0032967: positive regulation of collagen biosynthetic process
GO:0034616: response to laminar fluid shear stress
GO:0042476: odontogenesis
GO:0043065: positive regulation of apoptotic process
GO:0043524: negative regulation of neuron apoptotic process
GO:0043627: response to estrogen stimulus
GO:0043932: ossification involved in bone remodeling
GO:0045216: cell-cell junction organization
GO:0045740: positive regulation of DNA replication
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048286: lung alveolus development
GO:0048565: digestive tract development
GO:0048702: embryonic neurocranium morphogenesis
GO:0048839: inner ear development
GO:0050714: positive regulation of protein secretion
GO:0051491: positive regulation of filopodium assembly
GO:0051781: positive regulation of cell division
GO:0060021: palate development
GO:0060325: face morphogenesis
GO:0060364: frontal suture morphogenesis
GO:0060391: positive regulation of SMAD protein import into nucleus
GO:0070483: detection of hypoxia
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0009986: cell surface
GO:0030315: T-tubule
GO:0031012: extracellular matrix
GO:0031093: platelet alpha granule lumen
GO:0043025: neuronal cell body
GO:0005515: protein binding
GO:0005114: type II transforming growth factor beta receptor binding
GO:0050431: transforming growth factor beta binding
GO:0008083: growth factor activity
GO:0042802: identical protein binding
GO:0034713: type I transforming growth factor beta receptor binding
GO:0046982: protein heterodimerization activity
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4110: Cell cycle
4144: Endocytosis
4350: TGF-beta signaling pathway
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5144: Malaria
5145: Toxoplasmosis
5146: Amoebiasis
5200: Pathways in cancer
5210: Colorectal cancer
5211: Renal cell carcinoma
5212: Pancreatic cancer
5220: Chronic myeloid leukemia
5323: Rheumatoid arthritis
5410: Hypertrophic cardiomyopathy (HCM)
5414: Dilated cardiomyopathy

PubMed abstracts associated with TGFB3

PMID Title Tumor Value
9404699 Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression. yes yes
9605020 Relation between histological intensity of transforming growth factor-beta isoforms in human osteosarcoma and the rate of lung metastasis. yes yes
9771482 Expression of transforming growth factor beta isoforms in osteosarcoma variants: association of TGF beta 1 with high-grade osteosarcomas. yes no
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