Results for TGFBR1

General Information

Gene ID 7046
Gene Symbol TGFBR1
Gene Name transforming growth factor, beta receptor 1
Gene Type protein-coding
Cytoband 9q22
Ensembl ID ENSG00000106799
#miR regulators 17
Omim ID 132800 190181 608967 609192
Gene ontology GO:0000186: activation of MAPKK activity
GO:0001501: skeletal system development
GO:0001525: angiogenesis
GO:0001701: in utero embryonic development
GO:0001822: kidney development
GO:0001824: blastocyst development
GO:0001837: epithelial to mesenchymal transition
GO:0001937: negative regulation of endothelial cell proliferation
GO:0002088: lens development in camera-type eye
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006355: regulation of transcription, DNA-dependent
GO:0006468: protein phosphorylation
GO:0007050: cell cycle arrest
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007507: heart development
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0008354: germ cell migration
GO:0009791: post-embryonic development
GO:0009952: anterior/posterior pattern specification
GO:0010862: positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0018105: peptidyl-serine phosphorylation
GO:0018107: peptidyl-threonine phosphorylation
GO:0030199: collagen fibril organization
GO:0030307: positive regulation of cell growth
GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031396: regulation of protein ubiquitination
GO:0032331: negative regulation of chondrocyte differentiation
GO:0042060: wound healing
GO:0043062: extracellular structure organization
GO:0043393: regulation of protein binding
GO:0043542: endothelial cell migration
GO:0048538: thymus development
GO:0048663: neuron fate commitment
GO:0048701: embryonic cranial skeleton morphogenesis
GO:0048705: skeletal system morphogenesis
GO:0048762: mesenchymal cell differentiation
GO:0048844: artery morphogenesis
GO:0048870: cell motility
GO:0051272: positive regulation of cellular component movement
GO:0051491: positive regulation of filopodium assembly
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0060017: parathyroid gland development
GO:0060021: palate development
GO:0060037: pharyngeal system development
GO:0060389: pathway-restricted SMAD protein phosphorylation
GO:0060391: positive regulation of SMAD protein import into nucleus
GO:0070723: response to cholesterol
GO:0071560: cellular response to transforming growth factor beta stimulus
GO:2001235: positive regulation of apoptotic signaling pathway
GO:2001237: negative regulation of extrinsic apoptotic signaling pathway
GO:0005886: plasma membrane
GO:0005923: tight junction
GO:0043235: receptor complex
GO:0070022: transforming growth factor beta receptor homodimeric complex
GO:0005515: protein binding
GO:0004672: protein kinase activity
GO:0004674: protein serine/threonine kinase activity
GO:0004675: transmembrane receptor protein serine/threonine kinase activity
GO:0019838: growth factor binding
GO:0005024: transforming growth factor beta-activated receptor activity
GO:0005025: transforming growth factor beta receptor activity, type I
GO:0005114: type II transforming growth factor beta receptor binding
GO:0046872: metal ion binding
GO:0005524: ATP binding
GO:0050431: transforming growth factor beta binding
GO:0046332: SMAD binding
GO:0070411: I-SMAD binding
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4144: Endocytosis
4350: TGF-beta signaling pathway
4380: Osteoclast differentiation
4520: Adherens junction
5142: Chagas disease (American trypanosomiasis)
5200: Pathways in cancer
5210: Colorectal cancer
5212: Pancreatic cancer
5220: Chronic myeloid leukemia

PubMed abstracts associated with TGFBR1

PMID Title Tumor Value
14633705 SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. no no
20354825 Int7G24A variant of transforming growth factor-beta receptor 1 is associated with osteosarcoma susceptibility in a Chinese population. yes yes
20429896 Association between TGFBR1*6A and osteosarcoma: a Chinese case-control study. yes yes
title all all