General Information
Gene ID | 7048 |
---|---|
Gene Symbol | TGFBR2 |
Gene Name | transforming growth factor, beta receptor II (70/80kDa) |
Gene Type | protein-coding |
Cytoband | 3p22 |
Ensembl ID | ENSG00000163513 |
#miR regulators | 19 |
Omim ID | 133239 190182 610168 610380 614331 |
Gene ontology |
GO:0001568: blood vessel development GO:0001569: patterning of blood vessels GO:0001570: vasculogenesis GO:0001701: in utero embryonic development GO:0002053: positive regulation of mesenchymal cell proliferation GO:0002088: lens development in camera-type eye GO:0002651: positive regulation of tolerance induction to self antigen GO:0002663: positive regulation of B cell tolerance induction GO:0002666: positive regulation of T cell tolerance induction GO:0006915: apoptotic process GO:0006468: protein phosphorylation GO:0006898: receptor-mediated endocytosis GO:0009612: response to mechanical stimulus GO:0007179: transforming growth factor beta receptor signaling pathway GO:0007182: common-partner SMAD protein phosphorylation GO:0007224: smoothened signaling pathway GO:0007369: gastrulation GO:0007420: brain development GO:0007507: heart development GO:0007566: embryo implantation GO:0007568: aging GO:0007584: response to nutrient GO:0008284: positive regulation of cell proliferation GO:0042493: response to drug GO:0009749: response to glucose stimulus GO:0010634: positive regulation of epithelial cell migration GO:2000379: positive regulation of reactive oxygen species metabolic process GO:0018105: peptidyl-serine phosphorylation GO:0018107: peptidyl-threonine phosphorylation GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway GO:0031100: organ regeneration GO:0032147: activation of protein kinase activity GO:0035162: embryonic hemopoiesis GO:0042060: wound healing GO:0042127: regulation of cell proliferation GO:0043011: myeloid dendritic cell differentiation GO:0043415: positive regulation of skeletal muscle tissue regeneration GO:0043627: response to estrogen stimulus GO:0048565: digestive tract development GO:0048661: positive regulation of smooth muscle cell proliferation GO:0048701: embryonic cranial skeleton morphogenesis GO:0051138: positive regulation of NK T cell differentiation GO:0051216: cartilage development GO:0060021: palate development GO:0060044: negative regulation of cardiac muscle cell proliferation GO:0060389: pathway-restricted SMAD protein phosphorylation GO:0060434: bronchus morphogenesis GO:0060440: trachea formation GO:0060443: mammary gland morphogenesis GO:0060463: lung lobe morphogenesis GO:0070723: response to cholesterol GO:0005886: plasma membrane GO:0016021: integral to membrane GO:0005829: cytosol GO:0005901: caveola GO:0009897: external side of plasma membrane GO:0043235: receptor complex GO:0070022: transforming growth factor beta receptor homodimeric complex GO:0005515: protein binding GO:0004675: transmembrane receptor protein serine/threonine kinase activity GO:0004702: receptor signaling protein serine/threonine kinase activity GO:0005024: transforming growth factor beta-activated receptor activity GO:0005026: transforming growth factor beta receptor activity, type II GO:0046872: metal ion binding GO:0005524: ATP binding GO:0005539: glycosaminoglycan binding GO:0050431: transforming growth factor beta binding GO:0031435: mitogen-activated protein kinase kinase kinase binding GO:0034713: type I transforming growth factor beta receptor binding GO:0034714: type III transforming growth factor beta receptor binding GO:0046332: SMAD binding |
KEGG pathways |
4010: MAPK signaling pathway 4060: Cytokine-cytokine receptor interaction 4144: Endocytosis 4350: TGF-beta signaling pathway 4380: Osteoclast differentiation 4520: Adherens junction 5142: Chagas disease (American trypanosomiasis) 5200: Pathways in cancer 5210: Colorectal cancer 5212: Pancreatic cancer 5220: Chronic myeloid leukemia |
PMID | Title | Tumor | Value |
---|---|---|---|
23133552 | Modulation of the osteosarcoma expression phenotype by microRNAs. | yes | no |
title | all | all |