Results for THBS1

General Information

Gene ID 7057
Gene Symbol THBS1
Gene Name thrombospondin 1
Gene Type protein-coding
Cytoband 15q15
Ensembl ID ENSG00000137801
#miR regulators 11
Omim ID 188060
Gene ontology GO:0000187: activation of MAPK activity
GO:0001666: response to hypoxia
GO:0001937: negative regulation of endothelial cell proliferation
GO:0001953: negative regulation of cell-matrix adhesion
GO:0002040: sprouting angiogenesis
GO:0002544: chronic inflammatory response
GO:0002576: platelet degranulation
GO:0002581: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605: negative regulation of dendritic cell antigen processing and presentation
GO:0003151: outflow tract morphogenesis
GO:0003197: endocardial cushion development
GO:0003417: growth plate cartilage development
GO:0007596: blood coagulation
GO:0007155: cell adhesion
GO:0006955: immune response
GO:0007050: cell cycle arrest
GO:0043066: negative regulation of apoptotic process
GO:0042493: response to drug
GO:0009749: response to glucose stimulus
GO:0010595: positive regulation of endothelial cell migration
GO:0010596: negative regulation of endothelial cell migration
GO:2000379: positive regulation of reactive oxygen species metabolic process
GO:0010748: negative regulation of plasma membrane long-chain fatty acid transport
GO:0010751: negative regulation of nitric oxide mediated signal transduction
GO:0010754: negative regulation of cGMP-mediated signaling
GO:0010757: negative regulation of plasminogen activation
GO:0010759: positive regulation of macrophage chemotaxis
GO:0010763: positive regulation of fibroblast migration
GO:0010811: positive regulation of cell-substrate adhesion
GO:0045727: positive regulation of translation
GO:0016477: cell migration
GO:0016525: negative regulation of angiogenesis
GO:0018149: peptide cross-linking
GO:0030168: platelet activation
GO:0030194: positive regulation of blood coagulation
GO:0030198: extracellular matrix organization
GO:0030335: positive regulation of cell migration
GO:0030511: positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032026: response to magnesium ion
GO:0032570: response to progesterone stimulus
GO:0032695: negative regulation of interleukin-12 production
GO:0032914: positive regulation of transforming growth factor beta1 production
GO:0034605: cellular response to heat
GO:0040037: negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327: positive regulation of phosphorylation
GO:0042535: positive regulation of tumor necrosis factor biosynthetic process
GO:0043032: positive regulation of macrophage activation
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043536: positive regulation of blood vessel endothelial cell migration
GO:0043537: negative regulation of blood vessel endothelial cell migration
GO:0043652: engulfment of apoptotic cell
GO:0045766: positive regulation of angiogenesis
GO:0050921: positive regulation of chemotaxis
GO:0051592: response to calcium ion
GO:0051895: negative regulation of focal adhesion assembly
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0051918: negative regulation of fibrinolysis
GO:1900119: positive regulation of execution phase of apoptosis
GO:1902043: positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000353: positive regulation of endothelial cell apoptotic process
GO:2001237: negative regulation of extrinsic apoptotic signaling pathway
GO:0005576: extracellular region
GO:0005577: fibrinogen complex
GO:0005615: extracellular space
GO:0030141: secretory granule
GO:0009897: external side of plasma membrane
GO:0009986: cell surface
GO:0031012: extracellular matrix
GO:0031091: platelet alpha granule
GO:0031093: platelet alpha granule lumen
GO:0070062: extracellular vesicular exosome
GO:0005515: protein binding
GO:0005509: calcium ion binding
GO:0001786: phosphatidylserine binding
GO:0001948: glycoprotein binding
GO:0001968: fibronectin binding
GO:0005178: integrin binding
GO:0050431: transforming growth factor beta binding
GO:0008201: heparin binding
GO:0042802: identical protein binding
GO:0017134: fibroblast growth factor binding
GO:0030169: low-density lipoprotein particle binding
GO:0043236: laminin binding
GO:0043394: proteoglycan binding
GO:0070051: fibrinogen binding
GO:0070052: collagen V binding
KEGG pathways 4115: p53 signaling pathway
4145: Phagosome
4350: TGF-beta signaling pathway
4510: Focal adhesion
4512: ECM-receptor interaction
5144: Malaria
5219: Bladder cancer

PubMed abstracts associated with THBS1

PMID Title Tumor Value
2659348 Thrombospondin is synthesized and secreted by human osteoblasts and osteosarcoma cells. A model to study the different effects of thrombospondin in cell adhesion. no no
10703939 Platelet-osteosarcoma cell interaction is mediated through a specific fibrinogen-binding sequence located within the N-terminal domain of thrombospondin 1. no no
11156738 Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. no no
14719070 Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line. no no
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