Results for TIMP1

General Information

Gene ID 7076
Gene Symbol TIMP1
Gene Name TIMP metallopeptidase inhibitor 1
Gene Type protein-coding
Cytoband Xp11.3-p11.23
Ensembl ID ENSG00000102265
#miR regulators ---
Omim ID 305370
Gene ontology GO:0002576: platelet degranulation
GO:0007596: blood coagulation
GO:0007568: aging
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0022617: extracellular matrix disassembly
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0034097: response to cytokine stimulus
GO:0043249: erythrocyte maturation
GO:0043434: response to peptide hormone stimulus
GO:0051045: negative regulation of membrane protein ectodomain proteolysis
GO:1901164: negative regulation of trophoblast cell migration
GO:0005576: extracellular region
GO:0005604: basement membrane
GO:0031093: platelet alpha granule lumen
GO:0005515: protein binding
GO:0046872: metal ion binding
GO:0008191: metalloendopeptidase inhibitor activity
KEGG pathways ---

PubMed abstracts associated with TIMP1

PMID Title Tumor Value
7502710 Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. no no
9858899 Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. no no
10493528 S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. no no
14637192 Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. no no
14713104 S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. no no
15370596 Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. yes no
19682073 Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. no no
20798956 TIMP-1 interaction with ?v?3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-?-induced apoptosis. no no
20880700 Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma. yes yes
21113498 Matrix metalloproteinases 2, 7, 9 and tissue inhibitor of matrix metalloproteinase-1 in the sera of patients with bone tumors. yes yes
23175213 Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1. no no
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