General Information
Gene ID | 7076 |
---|---|
Gene Symbol | TIMP1 |
Gene Name | TIMP metallopeptidase inhibitor 1 |
Gene Type | protein-coding |
Cytoband | Xp11.3-p11.23 |
Ensembl ID | ENSG00000102265 |
#miR regulators | --- |
Omim ID | 305370 |
Gene ontology |
GO:0002576: platelet degranulation GO:0007596: blood coagulation GO:0007568: aging GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0022617: extracellular matrix disassembly GO:0030168: platelet activation GO:0030198: extracellular matrix organization GO:0034097: response to cytokine stimulus GO:0043249: erythrocyte maturation GO:0043434: response to peptide hormone stimulus GO:0051045: negative regulation of membrane protein ectodomain proteolysis GO:1901164: negative regulation of trophoblast cell migration GO:0005576: extracellular region GO:0005604: basement membrane GO:0031093: platelet alpha granule lumen GO:0005515: protein binding GO:0046872: metal ion binding GO:0008191: metalloendopeptidase inhibitor activity |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
7502710 | Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. | no | no |
9858899 | Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. | no | no |
10493528 | S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. | no | no |
14637192 | Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. | no | no |
14713104 | S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. | no | no |
15370596 | Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. | yes | no |
19682073 | Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. | no | no |
20798956 | TIMP-1 interaction with αvβ3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-α-induced apoptosis. | no | no |
20880700 | Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma. | yes | yes |
21113498 | Matrix metalloproteinases 2, 7, 9 and tissue inhibitor of matrix metalloproteinase-1 in the sera of patients with bone tumors. | yes | yes |
23175213 | Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1. | no | no |
title | all | all |