Results for TIMP2

General Information

Gene ID 7077
Gene Symbol TIMP2
Gene Name TIMP metallopeptidase inhibitor 2
Gene Type protein-coding
Cytoband 17q25
Ensembl ID ENSG00000035862
#miR regulators 17
Omim ID 188825
Gene ontology GO:0007417: central nervous system development
GO:0007568: aging
GO:0008285: negative regulation of cell proliferation
GO:0042493: response to drug
GO:0022617: extracellular matrix disassembly
GO:0030198: extracellular matrix organization
GO:0032487: regulation of Rap protein signal transduction
GO:0034097: response to cytokine stimulus
GO:0043410: positive regulation of MAPK cascade
GO:0045666: positive regulation of neuron differentiation
GO:0045762: positive regulation of adenylate cyclase activity
GO:0045861: negative regulation of proteolysis
GO:0045930: negative regulation of mitotic cell cycle
GO:0046580: negative regulation of Ras protein signal transduction
GO:0071310: cellular response to organic substance
GO:0005576: extracellular region
GO:0005604: basement membrane
GO:0005615: extracellular space
GO:0009986: cell surface
GO:0030426: growth cone
GO:0031514: motile cilium
GO:0043025: neuronal cell body
GO:0005178: integrin binding
GO:0046872: metal ion binding
GO:0008047: enzyme activator activity
GO:0008191: metalloendopeptidase inhibitor activity
KEGG pathways ---

PubMed abstracts associated with TIMP2

PMID Title Tumor Value
10493528 S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. no no
14637192 Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. no no
14713104 S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. no no
15370596 Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. yes no
18757369 Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. no no
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