General Information
Gene ID | 7077 |
---|---|
Gene Symbol | TIMP2 |
Gene Name | TIMP metallopeptidase inhibitor 2 |
Gene Type | protein-coding |
Cytoband | 17q25 |
Ensembl ID | ENSG00000035862 |
#miR regulators | 17 |
Omim ID | 188825 |
Gene ontology |
GO:0007417: central nervous system development GO:0007568: aging GO:0008285: negative regulation of cell proliferation GO:0042493: response to drug GO:0022617: extracellular matrix disassembly GO:0030198: extracellular matrix organization GO:0032487: regulation of Rap protein signal transduction GO:0034097: response to cytokine stimulus GO:0043410: positive regulation of MAPK cascade GO:0045666: positive regulation of neuron differentiation GO:0045762: positive regulation of adenylate cyclase activity GO:0045861: negative regulation of proteolysis GO:0045930: negative regulation of mitotic cell cycle GO:0046580: negative regulation of Ras protein signal transduction GO:0071310: cellular response to organic substance GO:0005576: extracellular region GO:0005604: basement membrane GO:0005615: extracellular space GO:0009986: cell surface GO:0030426: growth cone GO:0031514: motile cilium GO:0043025: neuronal cell body GO:0005178: integrin binding GO:0046872: metal ion binding GO:0008047: enzyme activator activity GO:0008191: metalloendopeptidase inhibitor activity |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
10493528 | S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. | no | no |
14637192 | Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. | no | no |
14713104 | S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. | no | no |
15370596 | Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. | yes | no |
18757369 | Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. | no | no |
title | all | all |