Results for TNF

General Information

Gene ID 7124
Gene Symbol TNF
Gene Name tumor necrosis factor
Gene Type protein-coding
Cytoband 6p21.3
Ensembl ID ENSG00000232810 ENSG00000228978 ENSG00000230108 ENSG00000228321 ENSG00000223952 ENSG00000228849 ENSG00000206439 ENSG00000204490
#miR regulators 11
Omim ID 191160 600807 611162
Gene ontology GO:0000060: protein import into nucleus, translocation
GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000165: MAPK cascade
GO:0000185: activation of MAPKKK activity
GO:0000187: activation of MAPK activity
GO:0001666: response to hypoxia
GO:0001775: cell activation
GO:0001819: positive regulation of cytokine production
GO:0001934: positive regulation of protein phosphorylation
GO:0002037: negative regulation of L-glutamate transport
GO:0002439: chronic inflammatory response to antigenic stimulus
GO:0002740: negative regulation of cytokine secretion involved in immune response
GO:0002876: positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925: positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0003009: skeletal muscle contraction
GO:0009615: response to virus
GO:0006915: apoptotic process
GO:0006006: glucose metabolic process
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006927: transformed cell apoptotic process
GO:0009612: response to mechanical stimulus
GO:0006954: inflammatory response
GO:0006959: humoral immune response
GO:0019722: calcium-mediated signaling
GO:0007254: JNK cascade
GO:0009887: organ morphogenesis
GO:0050796: regulation of insulin secretion
GO:0070265: necrotic cell death
GO:0050830: defense response to Gram-positive bacterium
GO:0008285: negative regulation of cell proliferation
GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors
GO:0042493: response to drug
GO:0009651: response to salt stress
GO:0010629: negative regulation of gene expression
GO:0010693: negative regulation of alkaline phosphatase activity
GO:0010888: negative regulation of lipid storage
GO:0010940: positive regulation of necrotic cell death
GO:0014823: response to activity
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0071230: cellular response to amino acid stimulus
GO:0030198: extracellular matrix organization
GO:0030316: osteoclast differentiation
GO:0030730: sequestering of triglyceride
GO:0031334: positive regulation of protein complex assembly
GO:0031622: positive regulation of fever generation
GO:0031663: lipopolysaccharide-mediated signaling pathway
GO:0032715: negative regulation of interleukin-6 production
GO:0032722: positive regulation of chemokine production
GO:0032729: positive regulation of interferon-gamma production
GO:0032755: positive regulation of interleukin-6 production
GO:0032800: receptor biosynthetic process
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0033209: tumor necrosis factor-mediated signaling pathway
GO:0044130: negative regulation of growth of symbiont in host
GO:0034116: positive regulation of heterotypic cell-cell adhesion
GO:0042346: positive regulation of NF-kappaB import into nucleus
GO:0043065: positive regulation of apoptotic process
GO:0043068: positive regulation of programmed cell death
GO:0043122: regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043242: negative regulation of protein complex disassembly
GO:0043243: positive regulation of protein complex disassembly
GO:0043280: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406: positive regulation of MAP kinase activity
GO:0043491: protein kinase B signaling cascade
GO:0043507: positive regulation of JUN kinase activity
GO:0043525: positive regulation of neuron apoptotic process
GO:0045071: negative regulation of viral genome replication
GO:0045080: positive regulation of chemokine biosynthetic process
GO:0045416: positive regulation of interleukin-8 biosynthetic process
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0045599: negative regulation of fat cell differentiation
GO:0045668: negative regulation of osteoblast differentiation
GO:0045672: positive regulation of osteoclast differentiation
GO:0045840: positive regulation of mitosis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0045994: positive regulation of translational initiation by iron
GO:0046325: negative regulation of glucose import
GO:0046330: positive regulation of JNK cascade
GO:0048566: embryonic digestive tract development
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0050715: positive regulation of cytokine secretion
GO:0050806: positive regulation of synaptic transmission
GO:0050901: leukocyte tethering or rolling
GO:0050995: negative regulation of lipid catabolic process
GO:0051023: regulation of immunoglobulin secretion
GO:0051044: positive regulation of membrane protein ectodomain proteolysis
GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051222: positive regulation of protein transport
GO:0051384: response to glucocorticoid stimulus
GO:0051533: positive regulation of NFAT protein import into nucleus
GO:0051798: positive regulation of hair follicle development
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0060555: activation of necroptosis by extracellular signals
GO:0060557: positive regulation of vitamin D biosynthetic process
GO:0060559: positive regulation of calcidiol 1-monooxygenase activity
GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060693: regulation of branching involved in salivary gland morphogenesis
GO:0061048: negative regulation of branching involved in lung morphogenesis
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0071316: cellular response to nicotine
GO:0071407: cellular response to organic cyclic compound
GO:0071677: positive regulation of mononuclear cell migration
GO:0071803: positive regulation of podosome assembly
GO:0097190: apoptotic signaling pathway
GO:0097191: extrinsic apoptotic signaling pathway
GO:2000010: positive regulation of protein localization to cell surface
GO:2000343: positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005886: plasma membrane
GO:0001891: phagocytic cup
GO:0005576: extracellular region
GO:0005887: integral to plasma membrane
GO:0005615: extracellular space
GO:0009897: external side of plasma membrane
GO:0009986: cell surface
GO:0045121: membrane raft
GO:0055037: recycling endosome
GO:0005515: protein binding
GO:0002020: protease binding
GO:0005125: cytokine activity
GO:0005164: tumor necrosis factor receptor binding
GO:0042802: identical protein binding
GO:0044212: transcription regulatory region DNA binding
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4210: Apoptosis
4350: TGF-beta signaling pathway
4380: Osteoclast differentiation
4612: Antigen processing and presentation
4620: Toll-like receptor signaling pathway
4621: NOD-like receptor signaling pathway
4622: RIG-I-like receptor signaling pathway
4640: Hematopoietic cell lineage
4650: Natural killer cell mediated cytotoxicity
4660: T cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4920: Adipocytokine signaling pathway
4930: Type II diabetes mellitus
4940: Type I diabetes mellitus
5010: Alzheimer's disease
5014: Amyotrophic lateral sclerosis (ALS)
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5143: African trypanosomiasis
5144: Malaria
5145: Toxoplasmosis
5146: Amoebiasis
5160: Hepatitis C
5310: Asthma
5322: Systemic lupus erythematosus
5323: Rheumatoid arthritis
5330: Allograft rejection
5332: Graft-versus-host disease
5410: Hypertrophic cardiomyopathy (HCM)
5414: Dilated cardiomyopathy

PubMed abstracts associated with TNF

PMID Title Tumor Value
1459694 Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. no no
1932372 Antitumor activity of TNF-alpha, IL-1, and IFN-gamma against three human osteosarcoma cell lines. no no
2450880 Tumor necrosis factor stimulates proliferation of human osteosarcoma cells and accumulation of c-myc messenger RNA. no no
8032535 Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line. no no
8670156 Recombinant human tumour necrosis factor-alpha suppresses synthesis, activity and secretion of lipoprotein lipase in cultures of a human osteosarcoma cell line. no no
9109391 Human osteosarcoma cell susceptibility to natural killer cell lysis depends on CD54 and increases after TNF alpha incubation. no no
9615784 Copper/zinc superoxide dismutase expression by different human osteosarcoma cell lines. no no
9664132 TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis. no no
9703945 Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells. no no
10339667 Expression of G1 phase regulators in MG-63 osteosarcoma cell line. no no
10536172 NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours. no no
11089884 Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines. no no
11235987 Antioxidants inhibit TNFalpha-induced motility and invasion of human osteosarcoma cells: possible involvement of NFkappaB activation. no no
11319838 Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells. no no
11820362 Regulation of TNF-alpha-induced IL-6 production in MG-63 human osteoblast-like cells. no no
12926161 Serum levels of TNF-beta and sTNF-R in patients with malignant bone tumours. yes yes
15516323 Effect of TNF-alpha on human osteosarcoma cell line Saos2--TNF-alpha regulation of bone sialoprotein gene expression in Saos2 osteoblast-like cells. no no
20053387 RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. no no
20798956 TIMP-1 interaction with ?v?3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-?-induced apoptosis. no no
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