Results for TP53

General Information

Gene ID 7157
Gene Symbol TP53
Gene Name tumor protein p53
Gene Type protein-coding
Cytoband 17p13.1
Ensembl ID ENSG00000141510
#miR regulators 9
Omim ID 114480 114500 114550 137800 151623 191170 202300 259500 260350 260500 607107 614740
Gene ontology GO:0000060: protein import into nucleus, translocation
GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000733: DNA strand renaturation
GO:0001701: in utero embryonic development
GO:0001756: somitogenesis
GO:0001836: release of cytochrome c from mitochondria
GO:0002309: T cell proliferation involved in immune response
GO:0002326: B cell lineage commitment
GO:0002360: T cell lineage commitment
GO:0002931: response to ischemia
GO:0007596: blood coagulation
GO:0008104: protein localization
GO:0031497: chromatin assembly
GO:0006284: base-excision repair
GO:0006289: nucleotide-excision repair
GO:0006302: double-strand break repair
GO:0006355: regulation of transcription, DNA-dependent
GO:0006461: protein complex assembly
GO:0006974: response to DNA damage stimulus
GO:0006977: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006983: ER overload response
GO:0007050: cell cycle arrest
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007265: Ras protein signal transduction
GO:0007275: multicellular organismal development
GO:0007369: gastrulation
GO:0007406: negative regulation of neuroblast proliferation
GO:0007417: central nervous system development
GO:0007569: cell aging
GO:0008156: negative regulation of DNA replication
GO:0043066: negative regulation of apoptotic process
GO:0008283: cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008340: determination of adult lifespan
GO:0009303: rRNA transcription
GO:0009651: response to salt stress
GO:0010165: response to X-ray
GO:0010332: response to gamma radiation
GO:0010666: positive regulation of cardiac muscle cell apoptotic process
GO:2000379: positive regulation of reactive oxygen species metabolic process
GO:2000378: negative regulation of reactive oxygen species metabolic process
GO:0042981: regulation of apoptotic process
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0046677: response to antibiotic
GO:0019048: modulation by virus of host morphology or physiology
GO:0030154: cell differentiation
GO:0030308: negative regulation of cell growth
GO:0030330: DNA damage response, signal transduction by p53 class mediator
GO:0030512: negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031065: positive regulation of histone deacetylation
GO:0031571: mitotic G1 DNA damage checkpoint
GO:0032461: positive regulation of protein oligomerization
GO:0033077: T cell differentiation in thymus
GO:0034103: regulation of tissue remodeling
GO:0034613: cellular protein localization
GO:0034644: cellular response to UV
GO:0035264: multicellular organism growth
GO:0035690: cellular response to drug
GO:0042149: cellular response to glucose starvation
GO:0042771: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065: positive regulation of apoptotic process
GO:0043525: positive regulation of neuron apoptotic process
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046902: regulation of mitochondrial membrane permeability
GO:0048147: negative regulation of fibroblast proliferation
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0051262: protein tetramerization
GO:0051097: negative regulation of helicase activity
GO:0051402: neuron apoptotic process
GO:0070245: positive regulation of thymocyte apoptotic process
GO:0071158: positive regulation of cell cycle arrest
GO:0071456: cellular response to hypoxia
GO:0071479: cellular response to ionizing radiation
GO:0071850: mitotic cell cycle arrest
GO:0072332: intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090200: positive regulation of release of cytochrome c from mitochondria
GO:0090343: positive regulation of cell aging
GO:0090399: replicative senescence
GO:0090403: oxidative stress-induced premature senescence
GO:0097193: intrinsic apoptotic signaling pathway
GO:0097252: oligodendrocyte apoptotic process
GO:1901525: negative regulation of macromitophagy
GO:2001244: positive regulation of intrinsic apoptotic signaling pathway
GO:0000785: chromatin
GO:0000790: nuclear chromatin
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005783: endoplasmic reticulum
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005657: replication fork
GO:0005669: transcription factor TFIID complex
GO:0005730: nucleolus
GO:0005759: mitochondrial matrix
GO:0016363: nuclear matrix
GO:0016604: nuclear body
GO:0016605: PML body
GO:0043234: protein complex
GO:0005515: protein binding
GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085: RNA polymerase II transcription factor binding
GO:0001228: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002020: protease binding
GO:0002039: p53 binding
GO:0003677: DNA binding
GO:0003682: chromatin binding
GO:0003684: damaged DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0051087: chaperone binding
GO:0005507: copper ion binding
GO:0005524: ATP binding
GO:0030971: receptor tyrosine kinase binding
GO:0008134: transcription factor binding
GO:0008270: zinc ion binding
GO:0042802: identical protein binding
GO:0044212: transcription regulatory region DNA binding
GO:0019899: enzyme binding
GO:0019901: protein kinase binding
GO:0031625: ubiquitin protein ligase binding
GO:0035033: histone deacetylase regulator activity
GO:0035035: histone acetyltransferase binding
GO:0046982: protein heterodimerization activity
GO:0047485: protein N-terminus binding
GO:0051721: protein phosphatase 2A binding
GO:0097371: MDM2/MDM4 family protein binding
KEGG pathways 4010: MAPK signaling pathway
4110: Cell cycle
4115: p53 signaling pathway
4210: Apoptosis
4310: Wnt signaling pathway
4722: Neurotrophin signaling pathway
5014: Amyotrophic lateral sclerosis (ALS)
5016: Huntington's disease
5160: Hepatitis C
5200: Pathways in cancer
5210: Colorectal cancer
5212: Pancreatic cancer
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5216: Thyroid cancer
5217: Basal cell carcinoma
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5222: Small cell lung cancer
5223: Non-small cell lung cancer

PubMed abstracts associated with TP53

PMID Title Tumor Value
1349175 Germ-line and somatic p53 gene mutations in multifocal osteogenic sarcoma. yes no
1423262 Mutation spectrum of the p53 gene in bone and soft tissue sarcomas. yes no
1423318 Analysis of a metastasizing testicular mixed gonadal stromal tumor with osteosarcoma components suggests that a malignant tumor with the histology of osteosarcoma may develop without primary involvement of RB1 and TP53. yes no
1447251 A significant proportion of patients with osteosarcoma may belong to Li-Fraumeni cancer families. yes no
1524989 Studies of the RB1 gene and the p53 gene in human osteosarcomas. yes no
1568211 Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. yes no
2143022 Mechanisms of p53 loss in human sarcomas. yes no
2233717 p53 functions as a cell cycle control protein in osteosarcomas. no no
2253237 Frequency and structure of p53 rearrangements in human osteosarcoma. yes no
2274789 Genetic mechanisms of tumor suppression by the human p53 gene. no no
2531855 Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line. no no
2978869 Specific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line. no no
3477902 Prognostic value of serum alkaline phosphatase in osteosarcoma. yes yes
7513549 Chromosome analysis of nine osteosarcomas. yes no
7559091 Changes in radiation sensitivity of human osteosarcoma cells after p53 introduction. no no
7576109 Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. no no
7614454 Complex replication error causes p53 mutation in a Li-Fraumeni family. yes no
7621257 Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53. no no
7828148 The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas. yes no
7911380 Rapid detection of loss of heterozygosity of chromosome 17p by polymerase chain reaction-based variable number of tandem repeat analysis and detection of single-strand conformation polymorphism of intragenic p53 polymorphisms. yes no
8034301 Single base pair germ-line deletion in the p53 gene in a cancer predisposed family. yes no
8058007 Secondary breast cancer in patients presenting with osteosarcoma: possible involvement of germline p53 mutations. yes no
8064888 MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status. yes no
8164043 Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma. yes no
8208533 Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53. no no
8260365 p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas. yes no
8401536 Screening for TP53 mutations in osteosarcomas using constant denaturant gel electrophoresis (CDGE). yes no
8418091 Analysis of mutant P53 protein in osteosarcomas and other malignant and benign lesions of bone. yes no
8425179 p53 abnormalities in different subtypes of human sarcomas. yes no
8479749 Constitutional mutation in exon 8 of the p53 gene in a patient with multiple primary tumours: molecular and immunohistochemical findings. yes no
8519637 p53 codon 213 (A-G) polymorphism in a Turkish population. yes no
8616838 Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. no no
8750062 Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. yes no
8781571 Alterations of the p53, Rb and MDM2 genes in osteosarcoma. yes no
8793483 Mutation spectrum of p53 gene in highly malignant human osteosarcomas. yes no
8821948 Molecular and immunohistochemical identification of p53 alterations in bone and soft tissue sarcomas. yes no
8891902 Oncogene alterations in primary, recurrent, and metastatic human bone tumors. yes yes
8959332 Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein. no no
9066701 Immunohistochemical detection of p53 protein overexpression in primary human osteosarcomas. yes no
9111202 Decrease in the frequency of X-ray-induced mutation by wild-type p53 protein in human osteosarcoma cells. no no
9118036 p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. yes yes
9136982 Differentiation induced by RB expression and apoptosis induced by p53 expression in an osteosarcoma cell line. no no
9167046 Histological and immunohistochemical diversities, and proliferative activity and grading in osteosarcomas. yes no
9175647 Suppression of UV-induced mutations by wild-type p53 protein in human osteosarcoma cells. no no
9187120 Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. no no
9227342 Point mutations and nucleotide insertions in the MDM2 zinc finger structure of human tumours. yes no
9275350 P53 gene abnormalities in osteosarcoma. yes no
9309118 Analysis of the p16INK4 and TP53 tumor suppressor genes in bone sarcoma pediatric patients. yes no
9416691 Analysis of p53 expression in osteosarcoma of the jaw: correlation with clinicopathologic and DNA ploidy findings. yes no
9461020 Reduced UV-induced mutations in human osteosarcoma cells stably expressing transfected wild-type p53 cDNA. no no
9480851 Suppression of high-density magnetic field (400 mT at 50 Hz)-induced mutations by wild-type p53 expression in human osteosarcoma cells. no no
9492043 p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. no no
9559293 Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas. yes no
9685858 Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas. yes yes
9723038 Correlation between apoptosis and TP53 status in osteosarcoma. yes no
9793960 Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors. yes yes
9820862 Genetic instability in osteoblastic tumors of the skeletal system. yes no
9824113 p53 gene mutations in osteosarcomas of low-grade malignancy. yes no
9891539 p53/MDM-2 immunohistochemical expression correlated with proliferative activity in different subtypes of human sarcomas: a ten-year follow-up study. yes no
9917506 Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma. yes yes
10232607 Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. no no
10498894 p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis. no no
10561353 Expression of HER2/erbB-2 correlates with survival in osteosarcoma. yes yes
10571205 A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. no no
10697522 De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line. no yes
10769661 Sensitization and caffeine potentiation of cisplatin cytotoxicity resulting from introduction of wild-type p53 gene in human osteosarcoma. no no
10942797 Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. yes yes
11087053 Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. yes yes
11115584 Osteosarcoma in blood relatives. yes no
11294418 The co-expression of p53 protein and P-glycoprotein is correlated to a poor prognosis in osteosarcoma. yes yes
11498785 Relative frequency and morphology of cancers in carriers of germline TP53 mutations. yes no
11596036 Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. yes no
11753985 Involvement of INK4A gene products in the pathogenesis and development of human osteosarcoma. yes yes
11797833 Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone. yes no
11943335 Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. no no
12012007 The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells. no no
12085209 Investigations on a clinically and functionally unusual and novel germline p53 mutation. yes no
12181274 Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. yes no
12478472 Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response. no no
12647018 Modulation of multidrug resistance-associated protein 1 (MRP1) by p53 mutant in Saos-2 cells. no no
12708477 Expression of the coxsackievirus and adenovirus receptor in musculoskeletal tumors and mesenchymal tissues: efficacy of adenoviral gene therapy for osteosarcoma. yes no
12747978 Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. yes no
12759621 Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. yes yes
12789260 Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. no no
12799638 Genetic alterations in primary osteosarcoma from 54 children and adolescents by targeted allelotyping. yes no
12850370 Chromosomal instability in osteosarcoma and its association with centrosome abnormalities. yes no
12917637 Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. yes no
12943619 Telomerase, p53 and PCNA activity in osteosarcoma. yes yes
12972634 The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. yes no
14506695 High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. yes no
14610316 Increased mdm-2 expression in a p53-independent manner blocks UV-induced cell cycle arrest and apoptosis in human osteosarcoma cells. no no
15026814 A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin. no no
15069760 HER-2/neu and p53 in osteosarcoma: an immunohistochemical and fluorescence in situ hybridization analysis. yes no
15112275 Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. yes yes
15167009 Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma. yes yes
15205094 Identification of a transcriptionally inactive p53 mutant by functional analysis of separated alleles in yeasts (FASAY) in a child osteosarcoma tumor: a case report. yes yes
15207713 Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. no no
15310147 Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma. yes no
15325100 Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma. yes no
15390294 Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with a germline p53 mutation. yes no
15448009 Prognostic significance of TP53 tumor suppressor gene expression and mutations in human osteosarcoma: a meta-analysis. yes yes
15488761 Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. yes no
15538723 Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes. no no
15662138 The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells. no no
15735124 TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study. yes no
15827336 p53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome. no no
15883045 Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. no no
16206219 CGH evaluation of two de novo synchronous tumors in a child with a germline p53 mutation. yes no
16211088 Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin. yes no
16328036 Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro. no no
16369996 Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells. no no
16596382 Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. yes no
16751779 Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma. no no
16814113 Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade. no no
17096406 Germ-line genetic variation of TP53 in osteosarcoma. yes no
17113707 Growth inhibition and sensitization to cisplatin by zoledronic acid in osteosarcoma cells. no no
17136003 p53 gene gets altered by various mechanisms: studies in childhood sarcomas and retinoblastoma. yes no
17206471 The transduction of His-TAT-p53 fusion protein into the human osteogenic sarcoma cell line (Saos-2) and its influence on cell cycle arrest and apoptosis. no no
17218778 Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. no no
17234448 Modulation of apoptotic signalling by 9-hydroxystearic acid in osteosarcoma cells. no no
17317953 Loss of TP53 in sarcomas with 17p12 to approximately p11 gain. A fine-resolution oligonucleotide array comparative genomic hybridization study. yes no
17356895 Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. no no
17366602 COPS3 amplification and clinical outcome in osteosarcoma. yes yes
17471233 Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. no no
17568187 Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. no no
17611411 P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner. no no
17786325 The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. no no
17959036 Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. no no
17981215 Identification of cryptic microaberrations in osteosarcoma by high-definition oligonucleotide array comparative genomic hybridization. no no
18161867 Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. yes yes
18307025 A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene. yes no
18384113 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest. no no
18510171 Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. no no
18606492 The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. no no
18931939 Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. no no
18989156 Germline p53 mutation in a Micronesian child with adrenocortical carcinoma and subsequent osteosarcoma. yes no
19012332 Somatic TP53 mutation mosaicism in a patient with Li-Fraumeni syndrome. yes no
19159633 Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. no no
19228774 Notch signaling contributes to the pathogenesis of human osteosarcomas. no no
19346874 Her-2/neu, p-53, and their coexpression in osteosarcoma. yes no
19451596 Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival. yes yes
19541929 Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. no no
19559722 Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. no no
19632201 Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples. yes no
19734943 Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. no no
19757179 beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. no no
19778378 U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. no no
20015022 Efficient growth inhibition of human osteosarcoma cells using a peptide derived from the MDM-2-binding site of p53. no no
20433742 Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. no no
20459648 The expression and significance of IDH1 and p53 in osteosarcoma. yes yes
20465837 Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy. yes yes
20701666 Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study. yes no
21159888 Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis. yes no
21163271 Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. no no
21192060 Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil. yes no
21234653 Anti-tumor effects of dihydroartemisinin on human osteosarcoma. no no
21240382 Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. yes yes
21345075 Multiple malignancies in a child with de novo TP53 mutation. yes no
21822538 p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. no no
21826611 Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. no no
21890444 Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. yes yes
21993662 Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. no no
22006429 High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. yes no
22205265 The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis. yes no
22471498 Cisplatin induces apoptosis via upregulating Wrap53 in U-2OS osteosarcoma cells. no no
22674530 Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. no no
22843172 MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells. no no
23113351 The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression. no no
23225447 Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis. yes no
23341181 Prognostic significance of p53 expression in malignant bone tumors: a meta-analysis. yes yes
23031740 Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: increased expression of a CD44 variant isoform after chemotherapy. yes no
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